Metabolomics 2021 Online, the second virtual conference that will take place from June 22-24, 2021. The conference will follow the general format that was instituted for Metabolomics 2020 Online, with the conference taking place in all time zones, enabling it to continue as a truly international event. They will open the conference with day 1 offering workshops on special interest topics, which has now become a tradition of the conference format. Days 2 and 3 will feature scientific sessions that will begin with a keynote speaker followed by talks selected from submitted abstracts and the ability for viewers to ask questions. There will be recorded talks available to access and watch later during the virtual event. There will be virtual poster sessions, networking opportunities, and special interest sessions that will include a town hall and early career member network meetings, among others.