by Anna Lukacs MSc, PhD | 02 Nov 2016
PMI Science representatives share their strategy and clinical results at the 51st Annual Meeting of the Japanese Medical Society of Alcohol and Addiction Studies
The Japanese Medical Society of Alcohol and Addiction Studies held its 51st annual meeting in Tokyo last month with a series of symposia on addictive behaviors. Harm reduction for topics including alcohol, gambling and nicotine addiction were discussed among experts in internal medicine, psychiatry, pharmacology, public health, pathology and industry representatives.
Dr Frank Lüdicke highlighted the role of heat-not-burn tobacco products in this context through the real-life success of the Tobacco Heating System 2.0 (THS2.2) in Japan. 70% of adult smokers who were introduced to THS2.2 are now predominant THS2.2 users accounting for 5% of tobacco market share in Japan (source: PM Japan IQOS User Panels).
Drs Gizelle Baker and Patrick Picavet jointly presented the THS 2.2 - A Heat-not-Burn Product Scientific Results to date. This ranged from characterizing constituents of THS2.2 aerosol, its effect on air quality and cellular systems; through registered clinical trials, to predicting the population health effects. PMI Science’s assessment strategy is unique in its completeness and transparency.
These studies show that the toxicological profile of THS2.2 in the laboratory is almost indistinguishable from conditions where no cigarette is present. Pharmacokinetic studies confirm that nicotine is delivered to consumers with THS2.2 at a similar rate and dose to that of a conventional cigarette. Harmful and potentially harmful compounds were reduced in THS2.2 aerosol by up to 96% compared to cigarettes and switching to THS2.2 in a clinical setting approached levels similar to cessation in terms of reduced exposure to these compounds.
The totality of evidence to date regarding the potential harm reduction effects of THS2.2 are very encouraging both in terms of individual risk reduction and at a population level.
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