The EUROoC conference series aims to gather the research leaders in the emerging field organs-on-chip (OoC) with a special focus on young and upcoming scientists. The extremely interdisciplinary field of OoC research is rapidly growing while new and innovative systems are constantly being developed. However, a variety of engineering challenges remain, which the OoC field has to address as a whole to enable a sustainable growth of this breakthrough technology. The EUROoC 2019 is a scientific meeting focused on the challenges in the process of designing, fabricating, and implementing microphysiological cell culture systems addressing topics such as microfabrication of 3D matrices, integration of miniaturised sensors, microfluidic interfacing, cellular engineering, parallelization, and automation. EUROoC 2019 is the official symposium of the European organ-on-chip society. The European organ-on-chip society was launched in November 2018.