The 4th German Pharm-Tox Summit will take place from 25–28 February 2019 in Stuttgart. Traditionally, this is a joint conference organised and held by the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) together with the Association of Clinical Pharmacology (VKliPha) and the Association for Applied Human Pharmacology (AGAH). To make the 4th German Pharm-Tox Summit an excellent scientific congress presenting cutting edge science from experimental and clinical Pharmacology and Toxicology, for the first time two Universities, namely Tübingen and Ulm, also represented by the two Congress Presidents from the German Societies of Clinical Pharmacology and Toxicology, respectively, join together with the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology in Stuttgart. The three plenary talks as well as the various symposia and the short talks sessions will provide exciting insight on hot topics of pharmacology, clinical pharmacology, and toxicology, but also allow to look across the borders of the own research topics.