The scientific program of the Summit includes plenary and keynote lectures, as well as oral and e-poster presentations, on the following specific topics: toxicology and aerosol chemistry, biomarkers’ evaluation in animal or human studies, preclinical evaluation, epidemiology & social Issues, clinical assessment and harm reduction, public health, legal & regulatory issues, bioethics, innovation & novel products, smoking cessation, and educational issues in adolescence. At this conference, PMI scientists present a talk on the use behaviours following the introduction of a novel THP product and its perceived reduced risk of harm in four countries.