Poster
Full Title
6-Aryl-β-Carbolines As Potent Tubulin-Polymerization Inhibitors
Authored by
P Blaney*, S Foster*, E Blaney*, S Hallworth*, A Smith*, P Doyle*, R Fisher*, A Teichert, G Lang, S Demotz, D McHugh, P Pospisil, FD Goffman
Presented at RSC ADVANCING THE CHEMICAL SCIENCES - HETEROCYCLIC & SYNTHESIS GROUP 21ST GRASMERE MEETING
* This author is not affiliated with PMI.
Presented at RSC ADVANCING THE CHEMICAL SCIENCES - HETEROCYCLIC & SYNTHESIS GROUP 21ST GRASMERE MEETING
* This author is not affiliated with PMI.
Abstract
Natural products have proven to be an excellent resource for discovering new potential drug candidates. For example, a recent study has shown that 64% of anti-cancer drugs and 76% of anti-bacterial drugs are natural products or derivatives.
1. Within a program aimed at the exploration of the biological activities of semisynthetic libraries based on natural product scaffolds – one of which was harmane 1 – 6-aryl-β-carbolines
2. Were identified as potent cytotoxic agents with an in vivo anti-tumour activity. The underlying mechanism was found to be microtubulin depolymerization by interaction with the colchicine binding site.
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Presented On
May 9, 2013 -
Link to Conference
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