Analysis of Philip Morris International THS 2.2 Aerosol


Authored by  PMI

For more information about the data and the smoke generation conditions, please read:

Platform 1's aerosol compared to reference cigarette smoke

Harmful and Potentially
Harmful Constituents

Units

Reference Cigarette Mean

THS 2.2 Mean

THS 2.2 SD

THS 2.2 n

THS 2.2 Reduction vs. reference cigarette

Nicotine

mg/stk

1.86

1.14

0.0332

9

-

Ammonia

µg/stk

29.3

10.5

1.63

9

64%

Acrylamide

µg/stk

4.46

1.82

0.116

9

59%

Pyridine

µg/stk

29.7

6.14

0.423

9

79%

Acetamide

µg/stk

12.9

3.33

0.394

9

74%

Butyraldehyde

µg/stk

83.5

20.3

0.586

9

76%

Styrene

µg/stk

15.4

1.05

0.145

9

93%

Pyrene

ng/stk

81.8

8.39

0.796

9

90%

Catechol

µg/stk

89.8

14.4

0.68

9

84%

Formaldehyde

µg/stk

85.2

7.98

0.504

9

91%

Propylene oxide

ng/stk

1103

136

19.9

9

88%

N-nitrosoanabasine (NAB)

ng/stk

30.2

1.92

0.182

9

94%

Benz[a]anthracene

ng/stk

27.1

2.08

0.148

9

92%

N-Nitrosonornicotine (NNN)

ng/stk

283

10.2

0.486

9

96%

Acetaldehyde

µg/stk

1641

217

7.85

9

87%

Propionaldehyde

µg/stk

123

13.6

0.662

9

89%

Benzo[a]pyrene

ng/stk

15

0.939

0.0796

9

94%

Phenol

µg/stk

14

1.12

0.0849

9

92%

N-nitrosoanatabine (NAT)

ng/stk

270

14

1.13

9

95%

Hydroquinone

µg/stk

89.1

7.2

0.391

9

92%

Acrolein

µg/stk

156

9.63

0.703

9

94%

4-(Methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

ng/stk

264

6.75

0.493

9

97%

Methyl-ethyl-ketone (MEK)

µg/stk

185

7.59

0.456

9

96%

Acetone

µg/stk

690

35.5

1.84

9

95%

Nitric oxide (NO)

µg/stk

504

13.8

0.967

9

97%

Nitrogen oxides (NOx)

µg/stk

560

14.1

0.943

9

97%

Toluene

µg/stk

137

1.82

0.163

9

98.70%

o-Cresol

µg/stk

4.15

0.0393

0.00649

9

99.10%

o-Toluidine

ng/stk

105

0.905

0.102

9

99.10%

Carbon monoxide (CO)

mg/stk

30.2

0.436

0.0811

9

98.60%

Acrylonitrile

µg/stk

24.5

0.158

0.0122

9

99.40%

Benzene

µg/stk

81.1

0.544

0.0312

9

99.30%

1, 3-Butadiene

µg/stk

98.5

0.342

0.0347

9

99.70%

Isoprene

µg/stk

894

2.15

0.202

9

99.80%

 

Aerosol generation:

 

Prior to conducting the aerosol generation experiment, all test items were conditioned according to ISO 3402 conditions (22°C ± 1°C and 60% ± 2%). The laboratory condition set during the aerosol generation was maintained at 22°C ± 2°C and 60% ± 5% relative humidity. All aerosol and smoke collections were performed according to the Health Canada Intense (HCI) machine-smoking protocol (55 mL puff volume, 30 seconds puff interval, 2 seconds puff, 100% vent blocking, butt length 23 mm for non-filter cigarettes or the length of filter overwrap plus 3 mm for filter brands) (Health Canada, 2000) on a linear smoking machine. For the THS 2.2, the vent blocking does not apply as the tobacco sticks are not ventilated (no perforation at the filter level). The butt length does not apply either, as the sticks are not consumed by combustion and remain of the same size throughout use. The beginning and the end of the aerosol collection for the tobacco sticks differs from what is applied to a cigarette, as there is not ignition and the stick is not consumed by combustion. The aerosol collection starts after the pre-heating period (30 seconds) and stops at 6 minutes, which is the end of the heating period. This results in exactly 12 puffs under HCI.

HPHCs approaching the< limit of quantification or detection.* Units Reference Cigarette Mean THS 2.2
Mean
THS 2.2
SD
THS 2.2
n
THS 2.2
Reduction vs. reference cigarette
1-Aminonaphthalene ng/stk 21.6 0.0407 0.0103 9 99.80%
2-Aminonaphthalene ng/stk 16.2 0.0277 0.00909 9 99.80%
3-Aminobiphenyl ng/stk 4.18 0.0112 0.0031 9 99.70%
4-Aminobiphenyl ng/stk 2.83 0.00958 0.0014 9 99.70%
Arsenic ng/stk 7.9 <1.2 * 9 NA
Cadmium ng/stk 92.9 <0.28 * 9 >99.7%
Chromium ng/stk <LOQ ND * 9 NA
Crotonaldehyde µg/stk 50.5 <3.29 * 9 >93%
Dibenz[a, h]anthracene ng/stk <LOQ ND * 9 NA
Ethylene oxide µg/stk 22.7 0.229 0.0126 9 99.00%
Hydrogen cyanide µg/stk 365 <4.37 * 9 >98.8%
Lead ng/stk 32.1 <1.62 * 9 >95%
m-Cresol µg/stk 3.51 <0.019 * 9 >99.5%
Mercury ng/stk 4.77 2.04 0.104 9 57.20%
Nickel ng/stk <LOQ ND * 9 NA
Nitro benzene µg/stk <LOQ ND * 9 NA
p-Cresol µg/stk 8.63 0.0456 * 9 99.50%
Quinoline µg/stk 0.431 <0.011 * 9 >97%
Resorcinol µg/stk 1.79 <0.055 * 9 NA
Selenium ng/stk 1.95 1.57 0.123 9 NA
Vinyl chloride ng/stk 103 <2.19 * 9 >98%


* The limit of quantification is the level below which the testing apparatus cannot reliably measure the levels of certain constituents. The level of detection is the level below which the testing apparatus cannot reliably detect the presence of certain constituents. In these situations, factors such as environmental contamination, laboratory reagents, and even the chemical composition of the tobacco leaf used in a product may trigger variations in the constituent levels. Constituents in this section, whilst they may be detected and/or quantifiable in one study, may not be detected and/or quantified in others.