Analysis of the extent of emphysema in live mice by high resolution X-ray microtomography

Authored by  AA Postnov*, K Meurrens, H Weiler, D Van Dyck, H Xu, P Terpstra, NM De Clerck*

Presented at Society for Molecular Imaging Annual Meeting     
* This author is not affiliated with PMI.

PMID: 16269065


High resolution X-ray microtomography (micro-CT) was used for the detection of emphysema in live mice. Emphysema was induced in C57BL/6 J mice by intratracheal instillation of different amounts of porcine pancreatic elastase. This emphysema could be clearly detected by micro-CT seven weeks post-treatment: analysis of the whole data set of virtual cross-sections showed the presence of a dose-dependent level of emphysema.