Formaldehyde-Glycerol Hemiacetal - Absence of “Hidden” Formaldehyde in THS 2.2. Aerosols

Authored by  A Knorr, L Gautier, A Debrick , E Tekeste, C Buchholz, M Almstetter, D Arndt, M Bentley

Presented at 3D Cell Culture DECHEMA Conference     


Reduced Risk Products (“RRPs”*) is the term used by PMI to refer to products with the potential to reduce individual risk and population harm in comparison to smoking cigarettes. We are developing a portfolio of products with the potential to reduce risk for adult smokers with a significant reduction in the levels of harmful and potentially harmful constituents (HPHCs) demonstrated in extensive and rigorous scientific studies.1 Along with many other HPHCs, formaldehyde levels measured in the aerosol generated by our THS**2.2 heat not burn platform was found to be reduced by 90% compared to the levels measured in the smoke of reference cigarette 3R4F2 on a per stick basis.*** In a recent correspondence in The New England Journal of Medicine from Jensen et al. the authors discussed the formation of hemiacetals from formaldehyde and humectants like propylene glycol or glycerol, associated with a potential risk of underestimating the uptake of formaldehyde by using e-cigarettes while operating under extreme energy delivery to the liquid. The formaldehyde hemiacetal (known as formaldehyde releasing agent) might represent a “hidden” formaldehyde, not covered by classical analytical approaches, releasing the formaldehyde portion after inhaling.