Advanced Search
Library
Peer-Reviewed Publication
Full Title

In Vivo Assessment Of Emphysema In Mice By High Resolution X-Ray Microtomography


Authored by  AA Postnov*, K Meurrens, H Weiler, D Van Dyck, H Xu, P Terpstra, NM De Clerck*

Published in The Journal of Microscopy     
* This author is not affiliated with PMI.

Abstract

High resolution X-ray microtomography (micro-CT) was used for the detection of emphysema in live mice. Emphysema was induced in c57Bl/6 J mice by intratracheal instillation of different amounts of porcine pancreatic elastase. This emphysema could be clearly detected by micro-CT seven weeks post-treatment: Analysis of the whole data set of virtual cross-sections showed the presence of a dose-dependent level of emphysema. 

 

PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris International’s efforts to develop and assess products that have the potential to reduce individual risk and population harm associated with tobacco use. This site is for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not for advertising or marketing. It is not intended for use by consumers.

Our RRPs

Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. Our RRPs are smoke-free products that produce an aerosol that contains far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.