In Vivo Assessment Of Emphysema In Mice By High Resolution X-Ray Microtomography

Authored by  AA Postnov*, K Meurrens, H Weiler, D Van Dyck, H Xu, P Terpstra, NM De Clerck*

Published in The Journal of Microscopy     
* This author is not affiliated with PMI.


High resolution X-ray microtomography (micro-CT) was used for the detection of emphysema in live mice. Emphysema was induced in c57Bl/6 J mice by intratracheal instillation of different amounts of porcine pancreatic elastase. This emphysema could be clearly detected by micro-CT seven weeks post-treatment: Analysis of the whole data set of virtual cross-sections showed the presence of a dose-dependent level of emphysema.