Peer-Reviewed Publication
Full Title
Occupational Acrylonitrile Exposure and Lung Cancer: A Meta-Analysis
Authored by
Z Sponsiello Wang, EB Sanders, R Weitkunat
Published in Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews
Published in Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews
Abstract
The present work summarizes the currently available published studies on lung cancer and occupational acrylonitrile exposure. Meta-analytic methods were used to estimate the overall risk. To adjust for the healthy worker effect, rate ratio estimates based on regression analyses and ratios of standard mortality ratios were aggregated. Overall effect estimates were 0.95 (95% CI 0.86 to 1.06) and 1.25 (95% CI 1.10 to 1.43) before and after adjustment for the healthy worker effect, respectively. Therefore, a 25% increase in lung cancer risk attributable to occupational acrylonitrile exposure is suggested. Possible contribution of smoking confounding the increased risk cannot be fully excluded.
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Published On
February 6, 2007 -
Full publication
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DOI
10.1080/10590500601006715 -
PMID: 17114112