Reduced Exposure To Harmful And Potentially Harmful Constituents After Five Days of Use of Tobacco Heating System 2.2. A Comparison with Continued Combustible Cigarette Use or Smoking Abstinence [Poland]


Authored by  C Haziza, G de La Bourdonnaye, P Picavet, G Baker, D Skiada, J Ancerewicz, K Jarus-Dziedzic*, F L├╝dicke

Presented at The Society of Toxicology Annual Meeting 2015     
* This author is not affiliated with PMI.

Abstract

The Tobacco Heating System (THS) 2.2 was developed to reduce or eliminate the formation of harmful and potentially harmful smoke constituents (HPHCs) in the aerosol through heating and not burning tobacco, while preserving as much as possible the taste, sensory experience, nicotine delivery profile and ritual characteristics of combustible cigarettes (CC).The study reported here is part of a global clinical program for THS 2.2 and was designed to demonstrate exposure reduction to selected HPHCs when switching from CC to THS 2.2 use in a controlled setting for 5 days, compared to those continuing to smoke CC. Smokers who abstained from smoking were used as a benchmark. The BoExp measured in this study represent 14 HPHCs, considered to provide a representative assessment of human uptake of a variety of toxicants and carcinogens in tobacco-products.This study also included endpoints to investigate the acceptance of THS 2.2 as a substitute to CC through assessment of subjective effects (questionnaire of smoking urges-Brief [QSU-Brief]; modified cigarette evaluation questionnaire [mCEQ]) 

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