Reductions In Exposure To Certain Cigarette Smoke Constituents After Switching From A Conventional Cigarette To Electrically Heated Cigarette Smoking Systems


Published By  C Martin Leroy, J Diekmann, D Lindner, A R Tricker, H Bleisath

Published in FRONTIERS IN AEROSOL DOSIMETRY RESEARCH     

Abstract

Introduction: The specific mainstream smoke constituents measured in this study are lower in electrically heated cigarette smoking systems (EHCSS) as compared to conventional cigarettes. This study investigates whether corresponding reductions are detectable in smokers. Methods: in a controlled-smoking study, 160 male and female adult caucasian smokers of Marlboro Lights (ml6; 6mgISO 'tar') were randomized to continue smoking ml6 or to switch to ehcss of either 5mg EHCSS-k6) or 3mg (EHCSS-k3) ISO 'tar' delivery, the Philip Morris 1 cigarette (pm 1; 1mg ISO' tar'); or No-Smoking (NS). Biomarkers were assessed at baseline (Day 0) and daily until day 8. Biomarkers of exposure to CO (Carboxyhemoglobin [COHb]) and nicotine (plasma cotinine) were determined at 17:00h. A-toluidine (o-Tol) and metabolites of nicotine (nicotine-equivalents [neq)), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (4-(methylnitrosamino)-1-(3 -pyridyi)-l-butanoi [total NNAA]), Benzene (s-phenylmercapturic acid [s-PMAI), Acrolein (3-hydroxypropylmercapturic acid [3-hpma]), 1,3-butadiene (monohydroxybutenylmercapturic acid [mhbma]), Crotonaldehyde (3-hydroxy-lmethylpropyimercapturic acid [HMPMAI), and Pyrene (l-hydroxypyrene [l-ohpj) were determined in 24-h urine. Results: mean percent changes from baseline to day 8 for ML6, PML,EHCSS-K6, SHCSS-K3, and NS were as follows: COHb (+28.1, -13.6, -70.1, -59.6, -89.4), Plasma Cotinine (-0.2, -30.6, -36.5, -53.9, -100), o-Tol (-11.9, -37.9, -61.7, -66.2, -70.5), NEQ (-1.6, -38.5, -43.8, -60.9, -100.0), total NNAL (+0.5, -18.9, -55.2, -60.1, -72.2), s-PMA (-4.8, -27.9, -79.4, -83.1, -93.1), 3HPMA (-13.6, -39.4, -35.5, -41.2, -72.2), MHBMA (-4.1, -34.1, -53.8, -54.4, -77.1), HMPMA (13.6, -21.6, -52.8, -54.8, -68.4), and l-OHP (-14.0, -37.0, -63.2, -64.0, -55.4). Conclusions: significant reductions

reductions-in-exposure-to-certain-cigarette-smoke-constituents