Developing a Mechanistic Understanding of the Scientific Substantiation of Reduced Risk Tobacco Products

Developing and commercializing reduced risk tobacco products has been one of PMI’s top priorities for many years.  Underlying the development of these products is the need for scientific validation of the risk reduction potential of such products. In order to build greater awareness around our science, we would like to take the opportunity to share our research on toxicology and systems biology approaches with you in more detail.

Schedule

4 September

15:00 to 15:10

M Smith

Review Of Smoke Chemistry Methodology And Reduction Of Selected Harmful And Potentially Harmful Constituents (HPHCs) In Mainstream Smoke

4 September

15:10 to 15:20

M Smith

In Vitro Comparison Of Combustible vs. Non-Combustible Tobacco Products

4 September

15:20 to 15:30

M Peitsch

J Hoeng

F Martin

Systems Toxicology In ApoE-/- Mice Demonstrates Similar Benefits Of Switch To pMRTP And Smoking Cessation For Both Cardiovascular And Lung Disease-Related Endpoints

4 September

15:30 to 15:40

M Peitsch

J Hoeng

P Vanscheeuwijck

28-Day Rat Inhalation Study – How Systems Toxicology Complements OECD Inhalation Studies

4 September

15:40 to 15:50

E Veljkovic

A Mechanistic Study Of Cigarette Smoke-Induced COPD And Cessation Effects In C57bl/6 Mice

4 September

15:50 to 16:00

J Hoeng

M Peitsch

F Martin

NV Ivanov

F Talamo

Systems Toxicology Assessment Of The Effect Of Repeated Cigarette Smoke Exposure On Human Respiratory Tract Tissue Cultures

4 September

16:00 to 16:10

M Peitsch

J Hoeng

E Veljkovic

P Vanscheeuwijck

F Martin

Systems Toxicology Approaches Enable Mechanistic Comparison Of Cigarette Smoke-Induced And Spontaneous Lung Tumors In The A/J Mouse Model

4 September

16:10 to 16:20

M Peitsch

J Hoeng

NV Ivanov

F Martin

In Vitro Evaluation Of The Biological Impact Of Harmful And Potentially Harmful Constituents Of Tobacco Smoke Using A Systems Toxicology Approach

4 September

16:20 to 16:30

M Peitsch

J Hoeng

Crowd-Verification Of Systems Biology Research Challenges: Species Translation And Biological Networks

4 September

16:30 to 16:40

B Phillips

Systems Toxicology-Based Comparisons Of Smoking Cessation And Switching To A Non- Combustible Tobacco Product In A Murine Model Of COPD