About Alexandra
I am responsible for the development and optimization of in-vitro cell-based assays used for the toxicological assessment of RRPs. I’m also involved in different projects related to cardiovascular diseases, lung cancer, toxicology, 2D and 3D models and working specifically on the development of the High Content screening platform.
Latest Publications
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Peer-Reviewed Publication
August 22, 2019
Heated Tobacco Products
3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow – application in systems toxicology
C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI.DOI : 10.14573/altex.1811301
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Peer-Reviewed Publication
July 17, 2018
Platform 2
In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells
C Poussin, A Laurent, A Kondylis, D Marescotti, M Van der Toorn, E Guedj, D Goedertier, S Acali, C Pak, R Dulize, K Baumer, D Peric, E Maluenda, D Bornand, I Gonzalez-Suarez, W Schlage, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.07.025
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Poster
August 25, 2017
Nicotine-Containing E-Vapor Products
3D vasculature-on-a-chip: a model of perfused human coronary artery endothelial microvessel for studying monocyte to endothelium adhesion under flow
C Poussin, V van Duinen*, HL Lanz*, A van den Heuvel*, B Kramer*, A Laurent, M Van der Toorn, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI. -
Poster
September 7, 2016
Nicotine-Containing E-Vapor Products
High Content Screening (HCS) approach to characterize phenotypic changes occurring during long-term treatment of human bronchial epithelial cells with cigarette smoke total particulate matter
D Marescotti, M Van der Toorn, A Laurent, K Luettich, S Frentzel, M Peitsch, J Hoeng
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Peer-Reviewed Publication
May 10, 2016
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
D Marescotti, I Gonzalez-Suarez, S Acali, S Johne, A Laurent, S Frentzel, J Hoeng, M Peitsch
JoVE - Journal of Visualized Experiments
DOI : 10.3791/53987
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Peer-Reviewed Publication
December 2, 2015
Platform 1
Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells
DOI : 10.1016/j.tox.2015.11.007
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Peer-Reviewed Publication
July 2, 2015
Systems biology reveals cigarette smoke-induced concentration-dependent direct and indirect mechanisms that promote monocyte-endothelial cell adhesion.