About Ashraf
I lead the proteomics team in performing protein biomarkers discovery and verification using state-of-art mass spectrometry and antibody techniques for product assessment within PMI Research and Development.
Latest Publications
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Peer-Reviewed Publication
February 12, 2019
Heated Tobacco Products
A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes
B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, A Choukrallah, T Schneider, NV Ivanov, Charles Teng, CK Tung, YS Yeo, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.02.008
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Peer-Reviewed Publication
January 2, 2019
Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarettes on gingival organotypic cultures.
F Zanetti, A Sewer, B Titz, W Schlage, A Iskandar, A Kondylis, P Leroy, E Guedj, K Trivedi, A Elamin, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.12.056
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Poster
December 3, 2018
Platform 1
Toxicological evaluation of the Tobacco Heating System 2.2, a candidate modified risk tobacco product in a OECD inhalation study complemented with systems toxicology
U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, P Vanscheeuwijck, J Hoeng, M Peitsch
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Poster
October 8, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
C Pater, C Haziza, A Elamin, S Pouly, G de La Bourdonnaye, CT Tran, F Lüdicke
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Poster
October 5, 2018
Platform 1
Systems toxicology assessment of potential modified risk tobacco products: effects on lung, liver, and heart in ApoE -/- mice using iTRAQ
C Nury, B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, A Choukrallah, T Schneider, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
September 21, 2018
Platform 1
Lung Inflammation, Emphysema, and Lung Cancer Development in A/J mice in Response to Chronic Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, B Titz, P Leroy, G Vuillaume, B Phillips, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng
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Peer-Reviewed Publication
April 11, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology
B Phillips, W Schlage, B Titz, U Kogel, D Sciuscio, F Martin, P Leroy, G Vuillaume, AS Krishnan *, PN Lee*, E Veljkovic, A Elamin, C Merg, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2018.04.015
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Peer-Reviewed Publication
March 13, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment
B Titz, U Kogel, F Martin, W Schlage, Y Xiang, C Nury, S Dijon, K Baumer, D Peric, D Bornand, R Dulize, B Phillips, P Leroy, G Vuillaume, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.058
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Poster
March 9, 2018
Platform 1
Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic nasal epithelial cultures - a view from the proteome
C Nury, A Iskandar, B Titz, P Leroy, T Schneider, S Dijon, C Merg, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
March 2, 2018
Platform 2
Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens
F Zanetti, A Sewer, E Scotti, B Titz, W Schlage, P Leroy, A Kondylis, G Vuillaume, A Iskandar, E Guedj, K Trivedi, T Schneider, A Elamin, F Martin, NV Ivanov, S Frentzel, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.062
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Peer-Reviewed Publication
March 1, 2018
Platform 2
Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment
A Iskandar, F Martin, P Leroy, W Schlage, C Mathis, B Titz, A Kondylis, T Schneider, G Vuillaume, A Sewer, E Guedj, K Trivedi, A Elamin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.063
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Poster
December 5, 2017
Platform 1
Systems Toxicology meta-analysis: Impact of a candidate Modified-Risk Tobacco Product aerosol compared with cigarette smoke on organotypic aerodigestive tract cultures
A Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Presentation
October 25, 2017
Platform 1
Translational Biomarker Discovery & INTERVALS: A Platform Facilitating Transparent Data Sharing
A Elamin, D Page
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Poster
September 28, 2017
Platform 1
Exposure to Cigarette Smoke and Aerosol from the Candidate Modified Risk Tobacco Product THS2.2 on A/J Mice in a Life-Time Inhalation Study
E T Wong, K Luettich, E Guedj, R Dulize, C Nury, B Titz, P Leroy, G Vuillaume, A Elamin, NV Ivanov, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 22, 2017
Platform 1
Proteomics as Part of a Multi-Omics Systems Toxicological Assessment of a Mentholated Candidate Modified Risk Tobacco Product
C Nury, U Kogel, B Titz, W Schlage, F Martin, A Oviedo, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 22, 2017
Platform 1
Integration of Targeted Proteomics into Systems Toxicology Approach: Candidate Modified-Risk Tobacco Product Assessment using Nasal Cultures
T Schneider, A Elamin, A Iskandar, F Zanetti, C Merg, A Sewer, B Titz, P Leroy, E Guedj, S Majeed, L Ortega Torres, W Schlage, C Mathis, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
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Poster
September 22, 2017
Heated Tobacco Products
Quantitative Proteomics to Investigate the Effects of a Prototype Modified Risk Tobacco Product (pMRTP) and Smoking Cessation on Mouse Lung Proteome.
S Dijon, A Elamin, B Titz, C Merg, M Geertz, T Schneider, F Martin, W Schlage, S Frentzel, F Talamo, E Veljkovic, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 20, 2017
Platform 1
Systems Toxicology Assessment of Repeated Exposure to Cigarette Smoke and a Candidate Modified-Risk Tobacco Product Aerosol on Gingival Organotypic Cultures
F Zanetti, A Sewer, P Leroy, S Majeed, L Ortega Torres, C Merg, M Corciulo, K Trivedi, E Guedj, A Elamin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
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Poster
September 20, 2017
Platform 1
Systems Toxicology Meta-Analysis: Impact of a Candidate Modified-Risk Tobacco Product Aerosol compared with Cigarette Smoke on Organotypic Aerodigestive Tract Cultures
A Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
September 5, 2017
Platform 4
Toxicity of the Main Electronic Cigarette Components, Propylene Glycol, Glycerin, and Nicotine, in Sprague-Dawley Rats in a 90-Day OECD Inhalation Study Complemented by Molecular Endpoints
B Phillips, B Titz, U Kogel, D Sharma, P Leroy, Y Xiang, G Vuillaume, S Lebrun, D Sciuscio, J Ho, C Nury, E Guedj, A Elamin, M Esposito, AS Krishnan *, W Schlage, E Veljkovic, NV Ivanov, F Martin, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Poster
September 4, 2017
Platform 1
In Vitro Systems Toxicology Assessment of Exposure to Aerosol from a Carbon Heated Tobacco Product as Compared with Exposure to Cigarette Smoke: The Impact on Nasal and Small Airway Epithelial Cultures
A Iskandar, Y Martinez, C Mathis, P Leroy, F Martin, A Sewer, L Ortega Torres, S Majeed, K Trivedi, S Frentzel, E Guedj, C Merg, A Elamin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
May 29, 2017
Platform 1
Systems Toxicology Meta-Analysis of In Vitro Assessment Studies: Biological Impact of a Candidate Modified-Risk Tobacco Product Aerosol Compared with Cigarette Smoke on Human Organotypic Cultures of the Aerodigestive Tract
A Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, J Hoeng, M Peitsch
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Poster
March 1, 2017
Platform 1
Comparative systems toxicology assessment of aerosol from a candidate modified risk tobacco product and cigarette smoke in organotypic human gingival epithelial cultures
F Zanetti, B Titz, A Sewer, G Lo Sasso, E Scotti, W Schlage, C Mathis, P Leroy, S Majeed, L Ortega Torres, BR Keppler*, A Elamin, K Trivedi, E Guedj, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
March 1, 2017
Platform 1
Candidate MRTP Aerosol has Low Impact on Organotypic Gingival Cultures
F Zanetti, B Titz, A Sewer, G Lo Sasso, E Scotti, W Schlage, C Mathis, P Leroy, S Majeed, L Ortega Torres, BR Keppler*, A Elamin, K Trivedi, E Guedj, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 23, 2016
Platform 1
Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study
F Zanetti, B Titz, A Sewer, G Lo Sasso, W Schlage, C Mathis, P Leroy, S Majeed, L Ortega Torres, BR Keppler*, A Elamin, K Trivedi, E Guedj, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2016.12.027
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Peer-Reviewed Publication
November 16, 2016
Platform 1
A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures
A Iskandar, C Mathis, W Schlage, S Frentzel, P Leroy, Y Xiang, A Sewer, S Majeed, L Ortega Torres, S Johne, E Guedj, K Trivedi, G Kratzer, C Merg, A Elamin, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.tiv.2016.11.009
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Peer-Reviewed Publication
November 4, 2016
Platform 1
Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke
U Kogel, B Titz, W Schlage, C Nury, F Martin, A Oviedo, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.11.001
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Peer-Reviewed Publication
July 13, 2016
Platform 1
Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures
F Zanetti, A Sewer, C Mathis, A Iskandar, R Kostadinova, W Schlage, P Leroy, S Majeed, E Guedj, K Trivedi, F Martin, A Elamin, C Merg, NV Ivanov, S Frentzel, M Peitsch, J Hoeng
Chemical Research in Toxicology
DOI : 10.1021/acs.chemrestox.6b00174
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Poster
July 1, 2016
Platform 1
Systems toxicology analysis of cardiovascular and respiratory endpoints from ApoE-/- mice showed similar effects when switching to a candidate Modified Risk Tobacco Product, THS2.2, or ceasing smoking
B Phillips, E Guedj, A Elamin, S Boue, G Vuillaume, F Martin, P Leroy, N Sierro, AW Hayes, E Veljkovic, NV Ivanov, M Peitsch, J Hoeng
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Poster
June 9, 2016
Platform 1
Effects of Cigarette Smoke, Cessation and Switching to Aerosol from Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in Two Mouse Strains
T Schneider, B Titz, S Boue, B Phillips, M Talikka, T Vihervaara*, C Nury, A Elamin, E Guedj, M Peck, W Schlage, M Cabanski, P Leroy, G Vuillaume, F Martin, NV Ivanov, E Veljkovic, K Ekroos*, R Laaksonen, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
June 5, 2016
Platform 2
Quantitative Proteomics Analysis Using 2D-PAGE to Investigate the Effects of Cigarette Smoke and Aerosol of a Prototypic Modified Risk Tobacco Product on the Lung Proteome in C57BL/6 Mice
A Elamin, B Titz, S Dijon, C Merg, M Geertz, T Schneider, F Martin, W Schlage, S Frentzel, F Talamo, B Phillips, E Veljkovic, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1016/j.jprot.2016.05.037
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Poster
May 2, 2016
Platform 1
Lung Inflammation and Toxicological Assessment in A/J Mice in Response to Chronic Exposure to Mainstream Aerosol from Candidate Modified Risk Tobacco Product and Smoke from Conventional Cigarettes
E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, E Veljkovic, AW Hayes, P Leroy, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
May 1, 2016
Heated Tobacco Products
Systems toxicology analysis of cardiovascular and respiratory endpoints from Apoe-/- mice showed similar effects when switching to a candidate modified risk tobacco product, THS2.2 or ceasing smoking
B Phillips, E Guedj, A Elamin, S Boue, G Vuillaume, F Martin, P Leroy, AW Hayes, E Veljkovic, M Peitsch, J Hoeng
DOI : 10.4172/2376-0419-C1-021
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Presentation
April 28, 2016
Nicotine-Containing E-Vapor Products
Comparative Proteomics Studies on Mice Lung Proteome for the Assessment of Candidate Modified Risk Tobacco Products
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Poster
January 29, 2016
Platform 1
Proteomics Analysis of the Lung Proteome in Two Different Strains of Mice Within Systems Toxicology Approach for Product Assessment to Investigate Effects of Switching to Candidate and Prototype Modified Risk Tobacco Products, or To Smoking Cessation
A Elamin, B Titz, S Dijon, C Nury, T Schneider, F Martin, B Phillips, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
January 5, 2016
Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice.
S Ansari, K Baumer, S Boue, S Dijon, R Dulize, K Ekroos*, A Elamin, C Foong, E Guedj, J Hoeng, NV Ivanov, AS Krishnan *, P Leroy, F Martin, C Merg, M Peck, M Peitsch, B Phillips, W Schlage, T Schneider, M Talikka, B Titz, P Vanscheeuwijck, E Veljkovic, T Vihervaara*, G Vuillaume, CQ Woon
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 11, 2015
Platform 1
Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/− mice – a systems toxicology analysis
G Lo Sasso, B Titz, C Nury, S Boue, B Phillips, V Belcastro, T Schneider, S Dijon, K Baumer, D Peric, R Dulize, A Elamin, E Guedj, A Buettner*, P Leroy, S Kleinhans, G Vuillaume, E Veljkovic, NV Ivanov, F Martin, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.3109/08958378.2016.1150368
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Peer-Reviewed Publication
November 25, 2015
Platform 1
An 8-Month systems toxicology inhalation/cessation study in Apoe-/- mice to investigate cardiovascular and respiratory exposure effects of a candidate modified risk tobacco product, THS 2.2
B Phillips, E Veljkovic, S Boue, W Schlage, G Vuillaume, F Martin, B Titz, P Leroy, A Buettner*, A Elamin, A Oviedo, M Cabanski, E Guedj, T Schneider, M Talikka, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfv243
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Peer-Reviewed Publication
November 17, 2015
Platform 1
Effects of cigarette smoke, cessation and switching to two heat-not-burn tobacco products on lung lipid metabolism in C57BL/6 and Apoe-/- mice – an integrative systems toxicology analysis
B Titz, B Phillips, S Boue, A Elamin, T Schneider, M Talikka, C Nury, T Vihervaara*, E Guedj, M Peck, W Schlage, M Cabanski, P Leroy, G Vuillaume, F Martin, NV Ivanov, E Veljkovic, K Ekroos*, R Laaksonen, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfv244
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Poster
November 10, 2015
Heated Tobacco Products
Assessment of the Tobacco Heating System 2.2, a candidate Modified Risk Tobacco Product, on human organotypic nasal and bronchial epithelial tissue culture using systems toxicology approach
F Zanetti, A Iskandar, C Mathis, M Cabanski, S Johne, D Kuehn, S Majeed, C Merg, A Elamin, E Guedj, R Dulize, D Peric, K Trivedi, A Benyagoub, Y Xiang, F Martin, P Leroy, S Frentzel, NV Ivanov, M Peitsch
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Poster
November 10, 2015
Heated Tobacco Products
Systems toxicology analysis of cardiovascular and respiratory endpoints from Apoe-/- mice showed similar effects after switching to a candidate modified risk tobacco product, THS 2.2, or to smoking cessation
B Phillips, E Veljkovic, S Boue, W Schlage, G Vuillaume, F Martin, B Titz, P Leroy, A Buettner*, A Elamin, M Cabanski, E Guedj, M Talikka, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
November 10, 2015
Toxicological evaluation of the Tobacco Heating System 2.2, a candidate Modified Risk Tobacco Product in a 90-Day OECD inhalation study complemented with systems toxicology
U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, G Rodrigo, E Veljkovic, J Hoeng, P Vanscheeuwijck, M Peitsch
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Peer-Reviewed Publication
September 2, 2015
Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects
B Titz, A Sewer, T Schneider, A Elamin, F Martin, S Dijon, K Luettich, E Guedj, G Vuillaume, NV Ivanov, M Peck, N Chaudhary, J Hoeng, M Peitsch
DOI : 10.1016/j.jprot.2015.08.009
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Peer-Reviewed Publication
April 22, 2015
Platform 2
A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product
B Phillips, E Veljkovic, M Peck, A Buettner*, A Elamin, E Guedj, G Vuillaume, NV Ivanov, F Martin, S Boue, W Schlage, T Schneider, B Titz, M Talikka, P Vanscheeuwijck, J Hoeng, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2015.03.009
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Poster
February 26, 2015
Platform 1
Human 3D Organotypic Nasal Epithelial Tissue Culture As An In Vitro Model To Evaluate Effects Of Cigarette Smoke Of A Candidate Modified Risk Tobacco Product: The Tobacco Heating System 2.2
C Mathis, M Cabanski, J Hoeng, S Frentzel, D Kuehn, S Majeed, C Merg, A Elamin, E Guedj, R Dulize, D Peric, K Trivedi, A Benyagoub, Y Xiang, F Martin, NV Ivanov, M Peitsch
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Poster
February 26, 2015
Molecular markers of early stage COPD in serum, sputum, and nasal epithelium from a case-control study
N Chaudhary, A Elamin, E Guedj, J Hoeng, NV Ivanov, K Luettich, P Leroy, F Martin, M Peitsch, A Sewer, M Talikka, B Titz, G Vuillaume
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Poster
October 5, 2014
Platform 2
A Mechanistic Study Using 2D-Page Proteomic Approach To Investigate The Effect Of Cigarette Smoke-Induced COPD, Cessation And Switching To Modified Risk Tobacco Product In The Lungs of C57bl/6 Mice
S Dijon, T Schneider, A Elamin, E Veljkovic, B Phillips, B Titz, F Martin, NV Ivanov, J Hoeng, M Peitsch
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Poster
October 5, 2014
Using an iTRAQ Approach to Investigate the Effect of Cigarette Smoke Exposure in a 90-day Inhalation Study Followed by 42-days Recovery Period on Sprague-Dawley Rats Lung Tissues
A Elamin, T Schneider, S Dijon, E T Wong, B Titz, F Martin, U Kogel, P Vanscheeuwijck, NV Ivanov, J Hoeng, M Peitsch
