About Bjorn
I contribute to the comprehensive systems toxicology assessment program of RRPs. This involves the analysis, integration, and interpretation of large-scale proteomics, lipidomics, metabolomics, and transcriptomics data.
Latest Publications
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Peer-Reviewed Publication
January 24, 2020
Nicotine-Containing E-Vapor Products
A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke
J Szostak, E T Wong, B Titz, T Lee, S K Wong, T Low, KM Lee*, J Zhang*, A Kumar*, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, Y Xiang, F Martin, A Sewer, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.American Journal of Physiology - Heart and Circulatory Physiology
DOI : 10.1152/ajpheart.00613.2019
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Peer-Reviewed Publication
November 6, 2019
Heated Tobacco Products
Structural, functional, and molecular impact on the cardiovascular system in ApoE−/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke
J Szostak, B Titz, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, L Neau, K Trivedi, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Chemico-Biological Interactions
DOI : 10.1016/j.cbi.2019.108887
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Peer-Reviewed Publication
September 7, 2019
Nicotine-Containing E-Vapor Products
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology
A Iskandar, F Zanetti, D Marescotti, B Titz, A Sewer, A Kondylis, P Leroy, V Belcastro, L Ortega Torres, S Acali, S Majeed, S Steiner, K Trivedi, E Guedj, C Merg, T Schneider, S Frentzel, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1007/s00204-019-02565-9
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Peer-Reviewed Publication
March 18, 2019
Nicotine-Containing E-Vapor Products
Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
KM Lee*, J Hoeng, S Harbo*, U Kogel, W Gardner*, M J Oldham*, E Benson*, M Talikka, A Kondylis, F Martin, B Titz, S Ansari, K Trivedi, E Guedj, A Elamin, NV Ivanov, P Vanscheeuwijck, M Peitsch, WJ McKinney*
* This author is not affiliated with PMI.DOI : 10.1080/08958378.2019.1576807
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Poster
March 16, 2019
Physiologically based Pharmacokinetic Modeling of Nicotine from Inhaled Aqueous Aerosol Predicts Marked Gastrointestinal Absorption in Rats
AR Kolli, F Martin, Y Xiang, B Titz, E T Wong, W Schlage, E Veljkovic, P Vanscheeuwijck, J Hoeng
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Poster
March 12, 2019
Heated Tobacco Products
Xenobiotic metabolism response to 3R4F or THS2.2 exposure: from pre-clinical to clinical
S Pouly, M Talikka, A van der Plas, B Titz, A Iskandar, G de La Bourdonnaye, N Blanc, F Martin, C Haziza, NV Ivanov, F Lüdicke, J Hoeng, M Peitsch
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Poster
February 28, 2019
Platform 1
Chronic Toxicity and Lung Carcinogenicity in A/J Mice Following Lifetime Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
K Luettich, E T Wong, K Trivedi, E Guedj, T Schneider, C Nury, B Titz, Y Xiang, P Leroy, G Vuillaume, P Vanscheeuwijck, NV Ivanov, M Peitsch, J Hoeng
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Poster
February 22, 2019
Platform 1
Impact of Switching to a Heat-Not-Burn Tobacco Product on CYP1A2 Activity: A Review of Four Clinical Studies
A van der Plas, N Blanc, C Haziza, B Titz, BV Taranu, N Ciuria, S Ciprietti, C Witt-Gonzalez, D Ancin, V Riccitelli, I D'Errico, M Pietro, L Prieto, R Weitkunat, NV Ivanov, F Lüdicke
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Poster
February 21, 2019
Systems Toxicology Assessment of Repeated Exposure of Human Organotypic Gingival Cultures to Swedish Snus Extracts and Total Particulate Matter from Cigarette Smoke
F Zanetti, A Sewer, B Titz, A Iskandar, A Kondylis, L Ortega Torres, C Pak, F Martin, E Guedj, K Trivedi, S Frentzel, NV Ivanov, J Hoeng, M Peitsch
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Peer-Reviewed Publication
February 12, 2019
Heated Tobacco Products
A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes
B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, C Teng, CK Tung, YS Yeo, P Vanscheeuwijck, M Peitsch, J Hoeng, WT Lim
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.02.008
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Peer-Reviewed Publication
January 2, 2019
Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarettes on gingival organotypic cultures.
F Zanetti, A Sewer, B Titz, W Schlage, A Iskandar, A Kondylis, P Leroy, E Guedj, K Trivedi, A Elamin, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.12.056
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Poster
December 3, 2018
Platform 1
Toxicological evaluation of the Tobacco Heating System 2.2, a candidate modified risk tobacco product in a OECD inhalation study complemented with systems toxicology
U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, P Vanscheeuwijck, J Hoeng, M Peitsch
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Poster
October 5, 2018
Platform 1
Systems toxicology assessment of potential modified risk tobacco products: effects on lung, liver, and heart in ApoE -/- mice using iTRAQ
C Nury, B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
September 21, 2018
Platform 1
Lung Inflammation, Emphysema, and Lung Cancer Development in A/J mice in Response to Chronic Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, B Titz, P Leroy, G Vuillaume, B Phillips, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 6, 2018
Platform 1
Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Two Reduced-Risk Products Compared with Conventional Cigarettes
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
June 25, 2018
Platform 1
The impact of aerosol from Carbon Heated Tobacco Product 1.2 compared with cigarette smoke on the cardiovascular system of ApoE-/- mice in a six-month inhalation study
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
May 9, 2018
Platform 1
Systems Toxicological Assessment of two Modified Risk Tobacco Products on Cardiovascular and Respiratory Effects in ApoE-/-mice - a six-month inhalation study
B Phillips, J Szostak, E Guedj, E T Wong, M Talikka, S Lebrun, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
April 11, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology
B Phillips, W Schlage, B Titz, U Kogel, D Sciuscio, F Martin, P Leroy, G Vuillaume, AS Krishnan *, PN Lee*, E Veljkovic, A Elamin, C Merg, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2018.04.015
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Peer-Reviewed Publication
March 13, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment
B Titz, U Kogel, F Martin, W Schlage, Y Xiang, C Nury, S Dijon, K Baumer, D Peric, D Bornand, R Dulize, B Phillips, P Leroy, G Vuillaume, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.058
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Poster
March 9, 2018
Platform 1
Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic nasal epithelial cultures - a view from the proteome
C Nury, A Iskandar, B Titz, P Leroy, T Schneider, S Dijon, C Merg, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
March 2, 2018
Platform 2
Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens
F Zanetti, A Sewer, E Scotti, B Titz, W Schlage, P Leroy, A Kondylis, G Vuillaume, A Iskandar, E Guedj, K Trivedi, T Schneider, A Elamin, F Martin, NV Ivanov, S Frentzel, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.062
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Peer-Reviewed Publication
March 1, 2018
Platform 2
Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment
A Iskandar, F Martin, P Leroy, W Schlage, C Mathis, B Titz, A Kondylis, T Schneider, G Vuillaume, A Sewer, E Guedj, K Trivedi, A Elamin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.063
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Poster
December 5, 2017
Platform 1
Systems Toxicology meta-analysis: Impact of a candidate Modified-Risk Tobacco Product aerosol compared with cigarette smoke on organotypic aerodigestive tract cultures
A Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Poster
November 16, 2017
Platform 1
Multiomics integration of transcriptomics, proteomics, and lipidomics for toxicological assessment
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Poster
September 28, 2017
Platform 1
Exposure to Cigarette Smoke and Aerosol from the Candidate Modified Risk Tobacco Product THS2.2 on A/J Mice in a Life-Time Inhalation Study
E T Wong, K Luettich, E Guedj, R Dulize, C Nury, B Titz, P Leroy, G Vuillaume, A Elamin, NV Ivanov, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 22, 2017
Platform 1
Proteomics as Part of a Multi-Omics Systems Toxicological Assessment of a Mentholated Candidate Modified Risk Tobacco Product
C Nury, U Kogel, B Titz, W Schlage, F Martin, A Oviedo, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 22, 2017
Platform 1
Integration of Targeted Proteomics into Systems Toxicology Approach: Candidate Modified-Risk Tobacco Product Assessment using Nasal Cultures
T Schneider, A Elamin, A Iskandar, F Zanetti, C Merg, A Sewer, B Titz, P Leroy, E Guedj, S Majeed, L Ortega Torres, W Schlage, C Mathis, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
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Poster
September 22, 2017
Heated Tobacco Products
Quantitative Proteomics to Investigate the Effects of a Prototype Modified Risk Tobacco Product (pMRTP) and Smoking Cessation on Mouse Lung Proteome.
S Dijon, A Elamin, B Titz, C Merg, M Geertz, T Schneider, F Martin, W Schlage, S Frentzel, F Talamo, E Veljkovic, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 20, 2017
Platform 1
Systems Toxicology Meta-Analysis: Impact of a Candidate Modified-Risk Tobacco Product Aerosol compared with Cigarette Smoke on Organotypic Aerodigestive Tract Cultures
A Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
September 5, 2017
Platform 4
Toxicity of the Main Electronic Cigarette Components, Propylene Glycol, Glycerin, and Nicotine, in Sprague-Dawley Rats in a 90-Day OECD Inhalation Study Complemented by Molecular Endpoints
B Phillips, B Titz, U Kogel, D Sharma, P Leroy, Y Xiang, G Vuillaume, S Lebrun, D Sciuscio, J Ho, C Nury, E Guedj, A Elamin, M Esposito, AS Krishnan *, W Schlage, E Veljkovic, NV Ivanov, F Martin, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Presentation
July 7, 2017
Proteomics for Systems Toxicology
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Peer-Reviewed Publication
June 14, 2017
Platform 1
Systems Biology: Methods and Applications
B Titz, A Knorr, A Sewer, F Martin, NV Ivanov, M Talikka, I Gonzalez-Suarez, M Peitsch, J Hoeng
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
Pages 434–480
DOI : 10.1016/B978-0-12-409547-2.12333-9
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Peer-Reviewed Publication
May 29, 2017
Platform 1
Systems Toxicology Meta-Analysis of In Vitro Assessment Studies: Biological Impact of a Candidate Modified-Risk Tobacco Product Aerosol Compared with Cigarette Smoke on Human Organotypic Cultures of the Aerodigestive Tract
A Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, J Hoeng, M Peitsch
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Poster
March 1, 2017
Platform 1
Comparative systems toxicology assessment of aerosol from a candidate modified risk tobacco product and cigarette smoke in organotypic human gingival epithelial cultures
F Zanetti, B Titz, A Sewer, G Lo Sasso, E Scotti, W Schlage, C Mathis, P Leroy, S Majeed, L Ortega Torres, BR Keppler*, A Elamin, K Trivedi, E Guedj, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
March 1, 2017
Platform 1
Candidate MRTP Aerosol has Low Impact on Organotypic Gingival Cultures
F Zanetti, B Titz, A Sewer, G Lo Sasso, E Scotti, W Schlage, C Mathis, P Leroy, S Majeed, L Ortega Torres, BR Keppler*, A Elamin, K Trivedi, E Guedj, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 23, 2016
Platform 1
Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study
F Zanetti, B Titz, A Sewer, G Lo Sasso, W Schlage, C Mathis, P Leroy, S Majeed, L Ortega Torres, BR Keppler*, A Elamin, K Trivedi, E Guedj, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2016.12.027
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Peer-Reviewed Publication
November 4, 2016
Platform 1
Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke
U Kogel, B Titz, W Schlage, C Nury, F Martin, A Oviedo, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.11.001
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Peer-Reviewed Publication
November 3, 2016
Platform 1
Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke
A Oviedo, S Lebrun, U Kogel, J Ho, W Teck Tan, B Titz, P Leroy, G Vuillaume, M Bera, F Martin, G Rodrigo, M Esposito, R Dempsey, NV Ivanov, J Hoeng, M Peitsch, P Vanscheeuwijck
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.11.004
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Publication
September 20, 2016
Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease
B Titz, K Luettich, P Leroy, S Boue, G Vuillaume, K Ekroos*, T Vihervaara*, F Martin, M Peitsch, J Hoeng
* This author is not affiliated with PMI.International Journal of Molecular Sciences
DOI : 10.3390/ijms17091583
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Poster
June 9, 2016
Platform 1
Effects of Cigarette Smoke, Cessation and Switching to Aerosol from Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in Two Mouse Strains
T Schneider, B Titz, S Boue, B Phillips, M Talikka, T Vihervaara*, C Nury, A Elamin, E Guedj, M Peck, W Schlage, M Cabanski, P Leroy, G Vuillaume, F Martin, NV Ivanov, E Veljkovic, K Ekroos*, R Laaksonen, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
June 5, 2016
Platform 2
Quantitative Proteomics Analysis Using 2D-PAGE to Investigate the Effects of Cigarette Smoke and Aerosol of a Prototypic Modified Risk Tobacco Product on the Lung Proteome in C57BL/6 Mice
A Elamin, B Titz, S Dijon, C Merg, M Geertz, T Schneider, F Martin, W Schlage, S Frentzel, F Talamo, B Phillips, E Veljkovic, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1016/j.jprot.2016.05.037
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Poster
January 29, 2016
Platform 1
Proteomics Analysis of the Lung Proteome in Two Different Strains of Mice Within Systems Toxicology Approach for Product Assessment to Investigate Effects of Switching to Candidate and Prototype Modified Risk Tobacco Products, or To Smoking Cessation
A Elamin, B Titz, S Dijon, C Nury, T Schneider, F Martin, B Phillips, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
January 5, 2016
Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice.
S Ansari, K Baumer, S Boue, S Dijon, R Dulize, K Ekroos*, A Elamin, C Foong, E Guedj, J Hoeng, NV Ivanov, AS Krishnan *, P Leroy, F Martin, C Merg, M Peck, M Peitsch, B Phillips, W Schlage, T Schneider, M Talikka, B Titz, P Vanscheeuwijck, E Veljkovic, T Vihervaara*, G Vuillaume, CQ Woon
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 11, 2015
Platform 1
Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/− mice – a systems toxicology analysis
G Lo Sasso, B Titz, C Nury, S Boue, B Phillips, V Belcastro, T Schneider, S Dijon, K Baumer, D Peric, R Dulize, A Elamin, E Guedj, A Buettner*, P Leroy, S Kleinhans, G Vuillaume, E Veljkovic, NV Ivanov, F Martin, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.3109/08958378.2016.1150368
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Peer-Reviewed Publication
November 25, 2015
Platform 1
An 8-month systems toxicology inhalation/cessation study in Apoe-/- mice to investigate cardiovascular and respiratory exposure effects of a candidate modified risk tobacco product, THS 2.2, compared with conventional cigarettes
B Phillips, E Veljkovic, S Boue, W Schlage, G Vuillaume, F Martin, B Titz, P Leroy, A Buettner*, A Elamin, A Oviedo, M Cabanski, E Guedj, T Schneider, M Talikka, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfv243
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Peer-Reviewed Publication
November 17, 2015
Effects of cigarette smoke, cessation and switching to two heat-not-burn tobacco products on lung lipid metabolism in C57BL/6 and Apoe-/- mice – an integrative systems toxicology analysis
B Titz, S Boue, B Phillips, M Talikka, T Vihervaara*, T Schneider, C Nury, A Elamin, E Guedj, M Peck, W Schlage, M Cabanski, P Leroy, G Vuillaume, F Martin, NV Ivanov, E Veljkovic, K Ekroos*, R Laaksonen, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfv244
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Poster
November 10, 2015
Heated Tobacco Products
Systems toxicology analysis of cardiovascular and respiratory endpoints from Apoe-/- mice showed similar effects after switching to a candidate modified risk tobacco product, THS 2.2, or to smoking cessation
B Phillips, E Veljkovic, S Boue, W Schlage, G Vuillaume, F Martin, B Titz, P Leroy, A Buettner*, A Elamin, M Cabanski, E Guedj, M Talikka, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.