About Carine
I lead various R&D projects in systems toxicology. These projects include risk assessment of new products, development of in vitro cardiovascular mechanistic assay portfolio and pre-clinical to clinical translational research. I also drive projects in the fields of computational data analysis and elaboration of crowd-sourced computational challenges for methods and data verification in systems biology and toxicology (sbvimprover.com).
Latest Publications
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Peer-Reviewed Publication
August 22, 2019
Heated Tobacco Products
3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow – application in systems toxicology
C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI.DOI : 10.14573/altex.1811301
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Presentation
March 16, 2019
Platform 1
Cardiovascular Effects of the Tobacco Heating System (THS) Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, C Poussin, P Vanscheeuwijck
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Poster
September 17, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Peer-Reviewed Publication
July 17, 2018
Platform 2
In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells
C Poussin, A Laurent, A Kondylis, D Marescotti, M Van der Toorn, E Guedj, D Goedertier, S Acali, C Pak, R Dulize, K Baumer, D Peric, E Maluenda, D Bornand, I Gonzalez-Suarez, W Schlage, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.07.025
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Poster
July 9, 2018
Crowdsourced-benchmarking of computational pipelines for metagenomic taxonomy profiling – the sbv IMPROVER Microbiomics Challenge
C Poussin, N Sierro, V Belcastro, JND Battey, S Boue, F Meyer*, E Scotti, A Petrelis, M Peitsch, NV Ivanov, J Hoeng
* This author is not affiliated with PMI. -
Poster
June 11, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Poster
May 9, 2018
Human Research Investigation on the Effects of Cigarette Smoking, E-Cigarette Vaping, and Smoking Cessation on Vascular Cell Biology
C Poussin, J Hoeng, S Ansari, E Guedj, TM Curran*, LA Baglia*, RA Berg*, N Blumberg*, SL Spinelli*, Loyse Felber Medlin , NV Ivanov, P Picavet, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 13, 2017
Exploring the microbiome in health and disease: Implications for toxicology
E Scotti, S Boue, G Lo Sasso, F Zanetti, V Belcastro, C Poussin, N Sierro, JND Battey, A Gimalac, NV Ivanov, J Hoeng
Toxicology Research and Application
DOI : 10.1177/2397847317741884
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Poster
August 25, 2017
Nicotine-Containing E-Vapor Products
3D vasculature-on-a-chip: a model of perfused human coronary artery endothelial microvessel for studying monocyte to endothelium adhesion under flow
C Poussin, V van Duinen*, HL Lanz*, A van den Heuvel*, B Kramer*, A Laurent, M Van der Toorn, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 14, 2017
Platform 1
The sbv IMPROVER Systems Toxicology computational challenge: Identification of human and species-independent blood response markers as predictors of smoking exposure and cessation status
V Belcastro, C Poussin, Y Xiang, M Giordano*, KP Tripathi*, A Boda, AT Balci*, I Bilgen*, SD Dhanda*, Z Duan*, X Gong*, R Kumar*, R Romero*, OS Sarac*, AL Tarca*, P Wang*, H Yang*, W Yang*, S Boue, C Zhang*, MR Guarracino*, F Martin, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.comtox.2017.07.004
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Presentation
February 8, 2017
Platform 1
An Assessment Strategy for Modified-Risk Tobacco Products (MRTP)
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Peer-Reviewed Publication
January 16, 2017
Platform 1
Crowd-sourced verification of computational methods and data in systems toxicology: a case study with a heat-not-burn candidate modified risk tobacco product
C Poussin, V Belcastro, F Martin, S Boue, M Peitsch, J Hoeng
Chemical Research in Toxicology
DOI : 10.1021/acs.chemrestox.6b00345
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Peer-Reviewed Publication
August 1, 2016
From Transcriptomics to Predictive Toxicology - The Systems Toxicology Computational Challenge
DOI : 10.1089/clinomi.03.08.08
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Peer-Reviewed Publication
December 2, 2015
Platform 1
Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells
DOI : 10.1016/j.tox.2015.11.007
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Peer-Reviewed Publication
July 2, 2015
Systems biology reveals cigarette smoke-induced concentration-dependent direct and indirect mechanisms that promote monocyte-endothelial cell adhesion.
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Peer-Reviewed Publication
May 12, 2015
Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains
M Cabanski, B Fields*, S Boue, N Boukharov*, H De Leon, N Dror*, M Geertz, E Guedj, A Iskandar, U Kogel, C Merg, M Peck, C Poussin, W Schlage, M Talikka, NV Ivanov, J Hoeng, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1007/s00011-015-0820-2
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Poster
March 23, 2015
Verification of Causal Biological Networks Using a Web-based Collaborative Competition
S Ansari, V Belcastro, S Boue, L Cannesson, M Costa, A Ertan, B Fields*, AW Hayes, J Hoeng, NV Ivanov, F Martin, D Page, J Park*, M Peitsch, C Poussin, M Talikka
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
March 9, 2015
A systems biology approach reveals the dose- and time-dependent effect of primary human airway epithelium tissue culture after exposure to cigarette smoke in vitro
C Mathis, S Gebel*, C Poussin, V Belcastro, A Sewer, D Weisensee, A Hengstermann*, S Ansari, S Wagner, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Bioinformatics and Biology Insights
DOI : 10.4137/BBI.S19908
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Poster
November 9, 2014
Comparison of the biological impact of cigarette smoke and a prototypic modified risk tobacco product on human versus rat primary normal bronchial epithelial cells
U Kogel, C Poussin, DE Messinis *, S Frentzel, I Gonzalez-Suarez, F Martin, C Mathis, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
October 7, 2014
A crowd-sourcing approach for the construction of species-specific cell signaling networks
E Bilal*, T Sakellaropoulos*, Challenge Participants*, IN Melas*, DE Messinis *, V Belcastro, K Rhrissorrakrai*, P Meyer*, R Norel*, A Iskandar, E Blaese*, JJ Rice*, M Peitsch, J Hoeng, G Stolovitzky, L Alexopoulos*, C Poussin
* This author is not affiliated with PMI.DOI : 10.1093/bioinformatics/btu659
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Poster
September 30, 2014
Reduced Impact of a Prototypic Modified Risk Tobacco Product Compared with Conventional Cigarette Smoke on Exposed Human and Rat Primary Normal Bronchial Epithelial Cells
C Mathis, U Kogel, DE Messinis *, C Poussin, F Martin, S Frentzel, E Guedj, NV Ivanov, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
September 17, 2014
Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge
K Rhrissorrakrai*, V Belcastro, E Bilal*, R Norel*, C Poussin, C Mathis, R Dulize, NV Ivanov, L Alexopoulos*, JJ Rice*, M Peitsch, G Stolovitzky, P Meyer*, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1093/bioinformatics/btu611
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Peer-Reviewed Publication
August 4, 2014
Mechanism of an indirect effect of aqueous cigarette smoke extract on the adhesion of monocytic cells to endothelial cells in an in vitro assay revealed by transcriptomics analysis
C Poussin, I Gallitz, W Schlage, Y Steffen, K Stolle, S Lebrun, J Hoeng, M Peitsch, M Lietz
DOI : 10.1016/j.tiv.2014.03.005
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Peer-Reviewed Publication
June 26, 2014
A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability
H De Leon, S Boue, W Schlage, N Boukharov*, JW Westra*, S Gebel*, A VanHooser*, M Talikka, B Fields*, E Veljkovic, M Peck, C Mathis, V Hoang*, C Poussin, R Deehan*, K Stolle, J Hoeng, M Peitsch
* This author is not affiliated with PMI.Journal of Translational Medicine
DOI : 10.1186/1479-5876-12-185
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Peer-Reviewed Publication
June 10, 2014
The Species Translation Challenge - A Systems Biology Perspective on Human and Rat Bronchial Epithelial Cells
C Poussin, C Mathis, L Alexopoulos*, DE Messinis *, R Dulize, V Belcastro, IN Melas*, T Sakellaropoulos*, K Rhrissorrakrai*, E Bilal*, P Meyer*, M Talikka, S Boue, R Norel*, JJ Rice*, G Stolovitzky, NV Ivanov, M Peck, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1038/sdata.2014.9
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Poster
March 17, 2014
Verification Of Systems Biology Research In The Age Of Collaborative Competition
E Bilal*, J Binder, E Blaese*, S Boue, M Charaf, P Curle, B Fields*, C Frei*, AW Hayes, A Iskandar, R Kleiman*, I Luhn*, P Meyer*, R Norel*, J Park*, C Poussin, K Rhrissorrakrai*, JJ Rice*, A Scotland, M Talikka, J Taylor, G Stolovitzky, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Poster
March 5, 2014
A Web Platform For Verification Of Biological Network Models In The Age Of Collaborative-Competition
S Ansari, DF Anseimo *, J Binder, S Boue, AW Hayes, J Hoeng, A Iskandar, R Kleiman*, R Norel*, B O'Neel, M Peitsch, C Poussin, D Pratt*, K Rhrissorrakrai*, W Schlage, G Stolovitzky, M Talikka
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
October 7, 2013
On Crowd-verification of Biological Networks
S Ansari, J Binder, S Boue, DF Anseimo *, AW Hayes, J Hoeng, A Iskandar, R Kleiman*, R Norel*, B O'Neel, M Peitsch, C Poussin, D Pratt*, K Rhrissorrakrai*, W Schlage, G Stolovitzky, M Talikka
* This author is not affiliated with PMI.Bioinformatics and Biology Insights
DOI : 10.4137/BBI.S12932
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Poster
September 15, 2013
Verification Of Systems Biology Research In The Age Of Collaborative- Competition: Biological Network Models
S Ansari, E Bilal*, J Binder, S Boue, P Curle, B Fields*, AW Hayes, J Hoeng, A Iskandar, R Norel*, M Peitsch, C Poussin, JJ Rice*, P Meyer*, K Rhrissorrakrai*, G Stolovitzky, M Talikka
* This author is not affiliated with PMI. -
Poster
September 1, 2013
Systems Biology Approach Reveals A Dose-Dependent Recovery Of Primary Human Airway Epithelium Culture After Exposure To Cigarette Smoke
C Mathis, S Gebel*, C Poussin, D Weisensee, A Sewer, V Belcastro, S Ansari, M Cabanski, S Wagner, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 29, 2013
Confero: An Integrated Contrast Data and Gene Set Platform for Computational Analysis and Biological Interpretation of Omics Data
L. Hermida, D Gaidatzis*, HR Hotz*, F Martin, V Belcastro, MB Stadler*, S Cano, M Peitsch, S Gubian, A Sewer, C Poussin, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 23, 2013
Systematic verification of upstream regulators of a computable cellular proliferation network model on non-diseased lung cells using a dedicated dataset
V Belcastro, C Poussin, S Gebel*, C Mathis, W Schlage, RB Lichtner, S Quadt-Humme, S Wagner, J Hoeng, M Peitsch
* This author is not affiliated with PMI.Bioinformatics and Biology Insights
DOI : 10.4137/BBI.S12167
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Poster
July 19, 2013
Verification Of Systems Biology Research: Species Translation And Biological Networks
E Bilal*, J Binder, S Boue, B Fields*, AW Hayes, A Iskandar, R Kleiman*, P Meyer*, R Norel*, J Park*, C Poussin, K Rhrissorrakrai*, JJ Rice*, J Sprengel*, M Talikka, G Stolovitzky, J Hoeng
* This author is not affiliated with PMI. -
Poster
June 12, 2013
Crowd-Verification Of Systems Biology Research Challenges: Species Translation And Biological Networks
E Bilal*, J Binder, S Boue, B Fields*, AW Hayes, A Iskandar, R Kleiman*, P Meyer*, R Norel*, J Park*, C Poussin, K Rhrissorrakrai*, JJ Rice*, J Sprengel*, G Stolovitzky, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
April 1, 2013
Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers
C Mathis, C Poussin, D Weisensee, S Gebel*, A Hengstermann*, A Sewer, V Belcastro, Y Xiang, S Ansari, S Wagner, J Hoeng, M Peitsch
* This author is not affiliated with PMI.American Journal of Physiology - Lung Cellular and Molecular Physiology
DOI : 10.1152/ajplung.00181.2012
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Poster
March 18, 2013
SBV Improver: The Species Translation Challenge
C Poussin, V Belcastro, E Bilal*, C Mathis, R Norel*, P Meyer*, JJ Rice*, J Sprengel*, G Stolovitzky, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
October 19, 2011
A Computable Cellular Stress Network Model for Non-diseased Pulmonary and Cardiovascular Tissue
W Schlage, JW Westra*, S Gebel*, NL Catlett*, C Mathis, B Frushour, A Hengstermann*, A VanHooser*, C Poussin, B Wong*, M Lietz, J Park*, DA Drubin*, E Veljkovic, M Peitsch, J Hoeng, R Deehan*
* This author is not affiliated with PMI.DOI : 10.1186/1752-0509-5-168
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Peer-Reviewed Publication
July 2, 2011
Construction of a Computable Cell Proliferation Network Focused on Non-Diseased Lung Cells
JW Westra*, W Schlage, B Frushour, S Gebel*, NL Catlett*, W Han, SF Eddy*, A Hengstermann*, AL Matthews*, C Mathis, RB Lichtner, C Poussin, M Talikka, E Veljkovic, A VanHooser*, B Wong*, MJ Maria*, M Peitsch, R Deehan*, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1186/1752-0509-5-105