About Davide
I lead a team of scientists responsible for the toxicological and pre-clinical evaluation of Reduced-Risk Products. In particular, by performing both in vitro and in vivo studies, we provide scientific support to product development, clinical studies, regulatory submissions, and market launches of RRPs.
Latest Publications
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Peer-Reviewed Publication
May 5, 2020
Nicotine-Containing E-Vapor Products
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis
J Ho, D Sciuscio, U Kogel, B Titz, P Leroy, G Vuillaume, M Talikka, E Martin, P Pospisil, S Lebrun, W Xia, T Lee, Y X Chng, B Phillips, E Veljkovic, E Guedj, Y Xiang, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
DOI : 10.1007/s00204-020-02759-6
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Poster
March 3, 2020
Nicotine-Containing E-Vapor Products
A structure-based grouping approach for evaluating the toxicity of e-cigarette flavor ingredients: A 5-week inhalation study in A/J mice
D Sciuscio, K Ashutosh*, P Leroy, A Nussbaum, K M Lee*, P Vanscheeuwijck, E T Wong, M Peitsch, K Luettich, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
November 25, 2019
Nicotine-Containing E-Vapor Products
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2019.11.016
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Peer-Reviewed Publication
September 9, 2019
Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles
DOI : 10.1080/08958378.2019.1662526
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Poster
March 12, 2019
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, K Baumer, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, K Luettich, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
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Poster
September 7, 2018
Platform 4
Systems Toxicology Assessment of Flavor Compounds Present in E-Vapor Products Using Human Primary Bronchial Epithelial Cells
D Marescotti, C Mathis, S Acali, V Belcastro, I Gonzalez-Suarez, S Frentzel, D Sciuscio, E Fernandes, M Biasioli, M Fuhrimann, F Frauendorfer, M Esposito, M Peitsch, J Hoeng
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Peer-Reviewed Publication
April 11, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology
B Phillips, W Schlage, B Titz, U Kogel, D Sciuscio, F Martin, P Leroy, G Vuillaume, AS Krishnan *, PN Lee*, E Veljkovic, A Elamin, C Merg, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2018.04.015
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Poster
March 16, 2018
Platform 4
Systems Toxicology Assessment of Flavor Compounds Present in E-Vapor Products Using Human Primary Bronchial Epithelial Cells
D Marescotti, C Mathis, S Acali, V Belcastro, I Gonzalez-Suarez, S Frentzel, D Sciuscio, E Fernandes, M Biasioli, M Fuhrimann, F Frauendorfer, M Esposito, M Peitsch, J Hoeng
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Peer-Reviewed Publication
September 5, 2017
Platform 4
Toxicity of the Main Electronic Cigarette Components, Propylene Glycol, Glycerin, and Nicotine, in Sprague-Dawley Rats in a 90-Day OECD Inhalation Study Complemented by Molecular Endpoints
B Phillips, B Titz, U Kogel, D Sharma, P Leroy, Y Xiang, G Vuillaume, S Lebrun, D Sciuscio, J Ho, C Nury, E Guedj, A Elamin, M Esposito, AS Krishnan *, W Schlage, E Veljkovic, NV Ivanov, F Martin, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Poster
September 9, 2016
Heated Tobacco Products
Toxicity of aerosols of propylene glycol, vegetable glycerin and nicotine in Sprague-Dawley rats in a 90d OECD 413 sub-chronic inhalation study
B Phillips, D Sharma, D Sciuscio, E Veljkovic, S Lebrun, J Verbeeck, W Teck Tan, U Kogel, J Ho, G Vuillaume, P Leroy, J Hoeng, M Peitsch, P Vanscheeuwijck