About Diego
I am responsible for the High Content Screening group which is involved in the toxicological assessment of Reduced-Risk Product aerosol fractions, single constituents and constituent mixtures.
Latest Publications
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Peer-Reviewed Publication
January 23, 2020
In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures
D Marescotti, D Bovard, M Morelli, A Sandoz, K Luettich, S Frentzel, M Peitsch, J Hoeng
SLAS TECHNOLOGY: Translating Life Sciences Innovation
DOI : 10.1177/2472630319895473
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Peer-Reviewed Publication
December 21, 2019
Applying Systems Toxicology Methods to Drug Safety
M Talikka, V Belcastro, S Boue, D Marescotti, J Hoeng, M Peitsch
DOI : 10.1016/B978-0-12-801238-3.11522-3
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Peer-Reviewed Publication
November 25, 2019
Nicotine-Containing E-Vapor Products
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2019.11.016
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Peer-Reviewed Publication
September 7, 2019
Nicotine-Containing E-Vapor Products
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology
A Iskandar, F Zanetti, D Marescotti, B Titz, A Sewer, A Kondylis, P Leroy, V Belcastro, L Ortega Torres, S Acali, S Majeed, S Steiner, K Trivedi, E Guedj, C Merg, T Schneider, S Frentzel, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1007/s00204-019-02565-9
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Peer-Reviewed Publication
March 18, 2019
GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology
V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1093/bioinformatics/btz187
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Poster
March 12, 2019
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, K Baumer, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, K Luettich, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
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Poster
March 12, 2019
GladiaTOX: global assessment of dose-response indicators in toxicology
V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
February 12, 2019
How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models
D Marescotti, T Serchi*, K Luettich, Y Xiang, E Moschini*, M Talikka, F Martin, K Baumer, R Dulize, D Peric, D Bornand, E Guedj, A Sewer, S Cambier*, S Contal*, A Chary*, AC Gutleb*, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.ALTEX Alternatives to Animal Experimentation
DOI : 10.14573/altex.1811221
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Peer-Reviewed Publication
November 21, 2018
A lung/liver-on-a-chip platform for acute and chronic toxicity studies
D Bovard, A Sandoz, K Luettich, S Frentzel, A Iskandar, D Marescotti, K Trivedi, E Guedj, Q Dutertre, M Peitsch, J Hoeng
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Poster
September 7, 2018
Characterization of a lung-liver organ-on-a-chip model
D Bovard, A Sandoz, M Morelli, D Marescotti, K Trivedi, K Luettich, S Frentzel, J Hoeng
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Poster
September 7, 2018
Platform 4
Systems Toxicology Assessment of Flavor Compounds Present in E-Vapor Products Using Human Primary Bronchial Epithelial Cells
D Marescotti, C Mathis, S Acali, V Belcastro, I Gonzalez-Suarez, S Frentzel, D Sciuscio, E Fernandes, M Biasioli, M Fuhrimann, F Frauendorfer, M Esposito, M Peitsch, J Hoeng
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Peer-Reviewed Publication
July 17, 2018
Platform 2
In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells
C Poussin, A Laurent, A Kondylis, D Marescotti, M Van der Toorn, E Guedj, D Goedertier, S Acali, C Pak, R Dulize, K Baumer, D Peric, E Maluenda, D Bornand, I Gonzalez-Suarez, W Schlage, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.07.025
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Poster
March 16, 2018
Platform 4
Systems Toxicology Assessment of Flavor Compounds Present in E-Vapor Products Using Human Primary Bronchial Epithelial Cells
D Marescotti, C Mathis, S Acali, V Belcastro, I Gonzalez-Suarez, S Frentzel, D Sciuscio, E Fernandes, M Biasioli, M Fuhrimann, F Frauendorfer, M Esposito, M Peitsch, J Hoeng
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Poster
March 16, 2018
Platform 1
Characterization of clones derived from human bronchial epithelial cells after long-term treatment with TPM from reference cigarettes versus THS 2.2
M Van der Toorn, M Sgandurra, D Marescotti, M Peitsch, J Hoeng, K Luettich
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Poster
March 16, 2018
Four-Week Continuous Nicotine Treatment of Immortalized Bronchial Epithelial Cells Does Not Contribute to Tumorigenesis
M Van der Toorn, K Baumer, D Peric, D Bornand, R Dulize, E Guedj, A Sewer, D Marescotti, K Luettich, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
March 7, 2018
Platform 1
The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product
M Van der Toorn, A Sewer, D Marescotti, S Johne, K Baumer, D Bornand, R Dulize, C Merg, M Corciulo, E Scotti, C Pak, P Leroy, E Guedj, NV Ivanov, F Martin, M Peitsch, J Hoeng, K Luettich
DOI : 10.1016/j.tiv.2018.02.019
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Poster
February 9, 2018
High-content screening-based phenotypic analysis of 3D organotypic bronchial tissues
D Marescotti, D Bovard, M Morelli, K Luettich, S Frentzel, M Peitsch, J Hoeng
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Peer-Reviewed Publication
March 3, 2017
Platform 4
In Vitro Systems Toxicology Assessment of Nonflavored e-Cigarette Liquids in Primary Lung Epithelial Cells
I Gonzalez-Suarez, D Marescotti, F Martin, E Scotti, E Guedj, S Acali, R Dulize, K Baumer, D Peric, S Frentzel, NV Ivanov, J Hoeng, M Peitsch
DOI : 10.1089/aivt.2016.0040
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Poster
September 7, 2016
Nicotine-Containing E-Vapor Products
High Content Screening (HCS) approach to characterize phenotypic changes occurring during long-term treatment of human bronchial epithelial cells with cigarette smoke total particulate matter
D Marescotti, M Van der Toorn, A Laurent, K Luettich, S Frentzel, M Peitsch, J Hoeng
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Presentation
June 29, 2016
High Content Screening-Based Analysis
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Peer-Reviewed Publication
May 10, 2016
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
D Marescotti, I Gonzalez-Suarez, S Acali, S Johne, A Laurent, S Frentzel, J Hoeng, M Peitsch
JoVE - Journal of Visualized Experiments
DOI : 10.3791/53987
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Peer-Reviewed Publication
May 9, 2016
Platform 4
A Framework for In Vitro Systems Toxicology Assessment of e-Liquids
A Iskandar, I Gonzalez-Suarez, S Majeed, D Marescotti, A Sewer, Y Xiang, P Leroy, E Guedj, C Mathis, JP Schaller, P Vanscheeuwijck, S Frentzel, F Martin, NV Ivanov, M Peitsch, J Hoeng
Toxicology Mechanisms and Methods
DOI : 10.3109/15376516.2016.1170251
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Poster
March 16, 2016
Heated Tobacco Products
Chronological Changes in BEAS-2B Cells Chronically Exposed to Cigarette Smoke to Total Particulate Matter
M Van der Toorn, D Marescotti, S Johne, C Merg, J Hoeng, M Peitsch, K Luettich
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Poster
March 16, 2016
Heated Tobacco Products
Development of a Primary Cell-Based Model of the Human Alveolar Epithelium
S Steiner, D Marescotti, S Acali, S Frentzel, C Mathis, K Luettich, J Hoeng
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Poster
March 14, 2016
Platform 1
Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Compared to a Combustible Cigarette
I Gonzalez-Suarez, F Martin, D Marescotti, E Guedj, S Acali, S Johne, R Dulize, K Baumer, D Peric, D Goedertier, S Frentzel, NV Ivanov, C Mathis, AW Hayes, J Hoeng, M Peitsch
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Poster
March 3, 2016
High Content Screening Assessment of Nicotine Toxicity in Primary Human Bronchial Epithelial Cells
I Gonzalez-Suarez, D Marescotti, S Acali, C Mathis, S Frentzel, J Hoeng, M Peitsch
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Peer-Reviewed Publication
December 10, 2015
Platform 1
In Vitro Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Shows Reduced Toxicity Compared to That of a Conventional Cigarette
I Gonzalez-Suarez, F Martin, D Marescotti, E Guedj, S Acali, S Johne, R Dulize, K Baumer, D Peric, D Goedertier, S Frentzel, NV Ivanov, C Mathis, J Hoeng, M Peitsch
Chemical Research in Toxicology
DOI : 10.1021/acs.chemrestox.5b00321
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Publication
December 10, 2015
In Vitro Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Shows Reduced Toxicity Compared to a Conventional Cigarette
I Gonzalez-Suarez, F Martin, D Marescotti, E Guedj, S Acali, S Johne, R Dulize, K Baumer, D Peric, D Goedertier, S Frentzel, NV Ivanov, C Mathis, J Hoeng, M Peitsch
Chemical Research in Toxicology
DOI : 10.1021/acs.chemrestox.5b00321
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Peer-Reviewed Publication
August 13, 2015
Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells.
U Kogel, I Gonzalez-Suarez, Y Xiang, E Dossin, P Guy, C Mathis, D Marescotti, D Goedertier, F Martin, M Peitsch, J Hoeng
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Poster
March 23, 2015
Mechanistic Network Models In Safety And Toxicity Evaluation Of Nutraceuticals
I Gonzalez-Suarez, D Marescotti, S Acali, S Johne, F Martin, R Dulize, K Baumer, D Peric, E Guedj, S Frentzel, C Mathis, NV Ivanov, J Hoeng, M Peitsch
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Poster
November 9, 2014
High Content Screening analysis of the Biological Impact of Harmful / Potentially Harmful Constituents of Tobacco Smoke
I Gonzalez-Suarez, D Marescotti, S Acali, S Johne, F Martin, R Dulize, K Baumer, D Peric, E Guedj, S Frentzel, C Mathis, NV Ivanov, J Hoeng, M Peitsch
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Poster
March 23, 2014
Multiplexed High Content Screening Analysis Reveals Reduced Toxicity Of A Prototypic Modified Risk Tobacco Product (pMRTP) As Compared To A Conventional Cigarette
I Gonzalez-Suarez, D Marescotti, S Acali, S Johne, D Goedertier, S Frentzel, C Mathis, AW Hayes, J Hoeng, M Peitsch
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Poster
January 16, 2014
Platform 2
In Vitro Toxicological Assessment Of Total Particulate Matter Of Tobacco Smoke And A pMRTP Aerosol In Human Lung Epithelial And Coronary Endothelial Cells
D Marescotti, I Gonzalez-Suarez, S Acali, S Johne, C Mathis, S Frentzel, P Walker*, S Ellis*, H Woodhouse*, H De Leon, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
January 15, 2014
A Systems Biology approach for evaluating the biological impact of environmental toxicants in vitro
I Gonzalez-Suarez, A Sewer, P Walker*, C Mathis, S Ellis*, H Woodhouse*, E Guedj, R Dulize, D Marescotti, S Acali, F Martin, NV Ivanov, J Hoeng, M Peitsch
* This author is not affiliated with PMI.Chemical Research in Toxicology
DOI : 10.1021/tx400405s