About Justyna
My work is predominantly dedicated to the construction of biological network models in the Biological Expression Language (BEL). I am also responsible for the design, usability, and performance of the BELIEF software and contribute to the design and omics data interpretation for Systems Toxicology studies.
Latest Publications
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Peer-Reviewed Publication
July 8, 2020
Systems toxicology approach for testing chemical cardiotoxicity in larval zebrafish
R Li*, A. Zupanic*, M Talikka, V Belcastro, S Madan*, J. Dörpinghaus*, C. vom Berg*, J Szostak, F Martin, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Chemical Research in Toxicology
DOI : 10.1021/acs.chemrestox.0c00095
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Peer-Reviewed Publication
May 14, 2020
Nicotine-Containing E-Vapor Products
E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model
MK Reumann*, J Schaefer*, B Titz, RH Aspera-Werz*, E T Wong, J Szostak, V Häussling*, S Ehnert*, P Leroy, W Teck Tan, A Kuczaj, C Audretsch*, F Springer*, A Badke*, P Augat*, L Quentanilla-Fend*, M Martella*, K M Lee*, M Peitsch, J Hoeng, AK Nussler*
* This author is not affiliated with PMI.DOI : 10.1007/s00204-020-02769-4
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Peer-Reviewed Publication
April 25, 2020
Heated Tobacco Products
Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
B Titz, J Szostak, A Sewer, B Phillips, C Nury, T Schneider, S Dijon, O Lavrynenko, A Elamin, E Guedj, E T Wong, S Lebrun, G Vuillaume, A Kondylis, S Gubian, S Cano, P Leroy, NV Ivanov, P Vanscheeuwijck, F Martin, M Peitsch, J Hoeng
Computational and Structural Biotechnology Journal
DOI : 10.1016/j.csbj.2020.04.011
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Peer-Reviewed Publication
January 24, 2020
Nicotine-Containing E-Vapor Products
A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke
J Szostak, E T Wong, B Titz, T Lee, S K Wong, T Low, KM Lee*, J Zhang*, K Ashutosh*, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, Y Xiang, F Martin, A Sewer, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.American Journal of Physiology - Heart and Circulatory Physiology
DOI : 10.1152/ajpheart.00613.2019
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Peer-Reviewed Publication
November 6, 2019
Heated Tobacco Products
Structural, functional, and molecular impact on the cardiovascular system in ApoE−/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke
J Szostak, B Titz, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, L Neau, K Trivedi, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Chemico-Biological Interactions
DOI : 10.1016/j.cbi.2019.108887
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Presentation
March 14, 2019
Nicotine-Containing E-Vapor Products
A six-month inhalation study in ApoE -/- mice to investigate cardiovascular and respiratory exposure effects of e-vapor aerosols compared with cigarette smoke
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Peer-Reviewed Publication
February 12, 2019
Heated Tobacco Products
A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes
B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, C Teng, CK Tung, YS Yeo, P Vanscheeuwijck, M Peitsch, J Hoeng, WT Lim
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.02.008
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Poster
October 5, 2018
Platform 1
Systems toxicology assessment of potential modified risk tobacco products: effects on lung, liver, and heart in ApoE -/- mice using iTRAQ
C Nury, B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
September 6, 2018
Platform 1
Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Two Reduced-Risk Products Compared with Conventional Cigarettes
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
June 25, 2018
Platform 1
The impact of aerosol from Carbon Heated Tobacco Product 1.2 compared with cigarette smoke on the cardiovascular system of ApoE-/- mice in a six-month inhalation study
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
May 9, 2018
Platform 1
Systems Toxicological Assessment of two Modified Risk Tobacco Products on Cardiovascular and Respiratory Effects in ApoE-/-mice - a six-month inhalation study
B Phillips, J Szostak, E Guedj, E T Wong, M Talikka, S Lebrun, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
March 22, 2017
Recent Improvements of the BEL Information Extraction workFlow (BELIEF) for Biomedical Text Mining and Curation
J Hoeng, M Peitsch, M Talikka, J Fluck*, J Doerpinghaus*, AW Hayes, S Madan*, J Szostak
* This author is not affiliated with PMI. -
Poster
March 17, 2017
The Adverse Outcome Pathway for Mucus Hypersecretion in Chronic Bronchitis
K Luettich, M Talikka, FJ Lowe*, LE Haswell, J Szostak, F Martin, M Gaca*, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 31, 2016
Improved knowledge acquisition and creation of structured knowledge for systems toxicology.
S Ansari, J Szostak, M Talikka, J Fluck*, J Hoeng
* This author is not affiliated with PMI.International Journal On Advances in Life Sciences
Int J Adv Life Sci 8: 309-319.
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Peer-Reviewed Publication
November 6, 2016
Semi-Automated Curation Allows Causal Network Model Building for the Quantification of Age-Dependent Plaque Progression in ApoE⁻/⁻ Mouse
Gene Regulation and Systems Biology
DOI : 10.4137/GRSB.S40031
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Peer-Reviewed Publication
August 30, 2016
The BEL Information Extraction Workflow (BELIEF): Evaluation in the BioCreative V BEL and IAT Track
S Madan*, S Hodapp*, P Senger*, S Ansari, J Szostak, J Hoeng, M Peitsch, J Fluck*
* This author is not affiliated with PMI.The Journal of Biological Databases and Curation
DOI : 10.1093/database/baw136
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Peer-Reviewed Publication
August 20, 2016
Training and evaluation corpora for the extraction of causal relationships encoded in biological expression language (BEL)
J Fluck*, S Madan*, S Ansari, AT Kodamullil*, R Karki*, M Rastegar-Mojarad*, NL Catlett*, WS Hayes, J Szostak, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Poster
April 14, 2016
Heated Tobacco Products
The BEL Information Extraction Workflow (BELIEF): Updates and Evaluation poster
S Ansari, S Madan*, J Szostak, P Senger*, M Talikka, J Fluck*, J Hoeng
* This author is not affiliated with PMI. -
Poster
January 29, 2016
Heated Tobacco Products
BELIEF: A semi-automated curation tool to build mechanisitc
J Szostak, S Ansari, M Talikka, J Fluck*, S Madan*, F Martin, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
January 9, 2016
Platform 1
Long term exposure to cigarette smoke impacts genes involved in cardiac muscle structure and function in Apoe-/- mouse while exposure to a candidate modified risk tobacco product, the Tobacco Heating System 2.2 (THS 2.2) aerosol does not
J Szostak, S Boue, M Talikka, E Guedj, F Martin, B Phillips, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
June 17, 2015
Construction of biological networks from unstructured information based on a semi-automated curation workflow.
J Szostak, S Ansari, S Madan*, J Fluck*, M Talikka, A Iskandar, H De Leon, M Hofmann-Apitius*, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1093/database/bav057
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Peer-Reviewed Publication
October 23, 2014
BELIEF - A semiautomatic workflow for BEL network creation
J Fluck*, S Madan*, S Ansari, J Szostak, J Hoeng, M Zimmermann, M Hofmann-Apitius*, M Peitsch
* This author is not affiliated with PMI.