About Nikolai
I lead a research technology department that comprises state-of-the-art experimental and in silico labs generating and handling omics and histological data.
Latest Publications
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Poster
February 22, 2019
Platform 1
Impact of Switching to a Heat-Not-Burn Tobacco Product on CYP1A2 Activity: A Review of Four Clinical Studies
A van der Plas, N Blanc, C Haziza, B Titz, BV Taranu, N Ciuria, S Ciprietti, C Witt-Gonzalez, D Ancin, V Riccitelli, I D'Errico, M Pietro, L Prieto, R Weitkunat, NV Ivanov, F Lüdicke
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Poster
February 21, 2019
Systems Toxicology Assessment of Repeated Exposure of Human Organotypic Gingival Cultures to Swedish Snus Extracts and Total Particulate Matter from Cigarette Smoke
F Zanetti, A Sewer, B Titz, A Iskandar, A Kondylis, L Ortega Torres, C Pak, F Martin, E Guedj, K Trivedi, S Frentzel, NV Ivanov, J Hoeng, M Peitsch
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Peer-Reviewed Publication
February 12, 2019
How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models
D Marescotti, T Serchi*, K Luettich, Y Xiang, E Moschini*, M Talikka, F Martin, K Baumer, R Dulize, D Peric, D Bornand, E Guedj, A Sewer, S Cambier*, S Contal*, A Chary*, AC Gutleb*, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.ALTEX Alternatives to Animal Experimentation
DOI : 10.14573/altex.1811221
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Peer-Reviewed Publication
February 12, 2019
Heated Tobacco Products
A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes
B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, A Choukrallah, T Schneider, NV Ivanov, Charles Teng, CK Tung, YS Yeo, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.02.008
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Peer-Reviewed Publication
February 7, 2019
Platform 1
Epigenomics in tobacco risk assessment: Opportunities for integrated new approaches
A Choukrallah, A Sewer, M Talikka, N Sierro, M Peitsch, J Hoeng, NV Ivanov
DOI : 10.1016/j.cotox.2019.01.001
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Peer-Reviewed Publication
January 2, 2019
Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarettes on gingival organotypic cultures.
F Zanetti, A Sewer, B Titz, W Schlage, A Iskandar, A Kondylis, P Leroy, E Guedj, K Trivedi, A Elamin, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.12.056
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Poster
December 3, 2018
Platform 1
Toxicological evaluation of the Tobacco Heating System 2.2, a candidate modified risk tobacco product in a OECD inhalation study complemented with systems toxicology
U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, P Vanscheeuwijck, J Hoeng, M Peitsch
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Peer-Reviewed Publication
November 29, 2018
The impact of genome evolution on the allotetraploid Nicotiana rustica – an intriguing story of enhanced alkaloid production
N Sierro, JND Battey, L Bovet, V Liedschulte, S Ouadi, J Thomas, Hervé Broye, H Laparra, A Vuarnoz, G Lang, S Goepfert, M Peitsch, NV Ivanov
DOI : 10.1186/s12864-018-5241-5
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Peer-Reviewed Publication
November 12, 2018
BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site
J Gordeeva*, N Morozova*, N Sierro, A Isaev*, T Sinkunas*, K Tsvetkova*, M Matlashov*, L Truncaitė*, RD Morgan*, NV Ivanov, V Siksnys*, L Zeng*, K Severinov*
* This author is not affiliated with PMI.DOI : 10.1093/nar/gky1125
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Peer-Reviewed Publication
November 9, 2018
Platform 1
Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke
A Choukrallah, N Sierro, F Martin, K Baumer, J Thomas, S Ouadi, J Hoeng, M Peitsch, NV Ivanov
DOI : 10.1016/j.fct.2018.11.020
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Poster
November 8, 2018
The impact of exposure to cigarette smoke on the secreton of inflammatory mediators: Assessment using human organotypic small airway epithelial cultures from five different donors
C Merg, M Corciulo, A Giralt, A Kondylis, L Ortega Torres, S Majeed, T Schneider, A Iskandar, NV Ivanov, J Hoeng
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Poster
October 5, 2018
Platform 1
Systems toxicology assessment of potential modified risk tobacco products: effects on lung, liver, and heart in ApoE -/- mice using iTRAQ
C Nury, B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, A Choukrallah, T Schneider, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
September 17, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Poster
September 6, 2018
Platform 1
Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Two Reduced-Risk Products Compared with Conventional Cigarettes
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 17, 2018
Platform 2
In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells
C Poussin, A Laurent, A Kondylis, D Marescotti, M Van der Toorn, E Guedj, D Goedertier, S Acali, C Pak, R Dulize, K Baumer, D Peric, E Maluenda, D Bornand, I Gonzalez-Suarez, W Schlage, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.07.025
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Poster
July 9, 2018
Crowdsourced-benchmarking of computational pipelines for metagenomic taxonomy profiling – the sbv IMPROVER Microbiomics Challenge
C Poussin, N Sierro, V Belcastro, JND Battey, S Boue, F Meyer*, E Scotti, A Petrelis, M Peitsch, NV Ivanov, J Hoeng
* This author is not affiliated with PMI. -
Poster
June 25, 2018
Platform 1
The impact of aerosol from Carbon Heated Tobacco Product 1.2 compared with cigarette smoke on the cardiovascular system of ApoE-/- mice in a six-month inhalation study
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
June 11, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Presentation
May 21, 2018
Platform 1
Molecular biomarkers elucidate the role of inflammation and oxidative stress in smoking-related diseases
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Peer-Reviewed Publication
May 10, 2018
SolCyc: a database hub at the Sol Genomics Network (SGN) for the manual curation of metabolic networks in Solanum and Nicotiana specific databases
H Foerster*, A Bombarely*, JND Battey, N Sierro, NV Ivanov, LA Mueller*
* This author is not affiliated with PMI. -
Poster
May 9, 2018
Platform 1
Systems Toxicological Assessment of two Modified Risk Tobacco Products on Cardiovascular and Respiratory Effects in ApoE-/-mice - a six-month inhalation study
B Phillips, J Szostak, E Guedj, E T Wong, M Talikka, S Lebrun, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
May 9, 2018
Human Research Investigation on the Effects of Cigarette Smoking, E-Cigarette Vaping, and Smoking Cessation on Vascular Cell Biology
C Poussin, J Hoeng, S Ansari, E Guedj, TM Curran*, LA Baglia*, RA Berg*, N Blumberg*, SL Spinelli*, Loyse Felber Medlin , NV Ivanov, P Picavet, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
April 11, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology
B Phillips, W Schlage, B Titz, U Kogel, D Sciuscio, F Martin, P Leroy, G Vuillaume, AS Krishnan *, PN Lee*, E Veljkovic, A Elamin, C Merg, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2018.04.015
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Poster
March 16, 2018
Four-Week Continuous Nicotine Treatment of Immortalized Bronchial Epithelial Cells Does Not Contribute to Tumorigenesis
M Van der Toorn, K Baumer, D Peric, D Bornand, R Dulize, E Guedj, A Sewer, D Marescotti, K Luettich, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
March 13, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment
B Titz, U Kogel, F Martin, W Schlage, Y Xiang, C Nury, S Dijon, K Baumer, D Peric, D Bornand, R Dulize, B Phillips, P Leroy, G Vuillaume, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.058
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Poster
March 9, 2018
Platform 1
Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic nasal epithelial cultures - a view from the proteome
C Nury, A Iskandar, B Titz, P Leroy, T Schneider, S Dijon, C Merg, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
March 7, 2018
Platform 1
The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product
M Van der Toorn, A Sewer, D Marescotti, S Johne, K Baumer, D Bornand, R Dulize, C Merg, M Corciulo, E Scotti, C Pak, P Leroy, E Guedj, NV Ivanov, F Martin, M Peitsch, J Hoeng, K Luettich
DOI : 10.1016/j.tiv.2018.02.019
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Peer-Reviewed Publication
March 2, 2018
Platform 2
Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens
F Zanetti, A Sewer, E Scotti, B Titz, W Schlage, P Leroy, A Kondylis, G Vuillaume, A Iskandar, E Guedj, K Trivedi, T Schneider, A Elamin, F Martin, NV Ivanov, S Frentzel, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.062
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Peer-Reviewed Publication
March 1, 2018
Platform 2
Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment
A Iskandar, F Martin, P Leroy, W Schlage, C Mathis, B Titz, A Kondylis, T Schneider, G Vuillaume, A Sewer, E Guedj, K Trivedi, A Elamin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.063
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Peer-Reviewed Publication
February 5, 2018
Organization of the TC and TE cT-DNA regions in Nicotiana otophora and functional analysis of three diverged TE-6b genes
K Chen*, F Dorlhac de Borne*, N Sierro, NV Ivanov, M Alouia*, S Koechler*, L Otten*
* This author is not affiliated with PMI.DOI : 10.1111/tpj.13853
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Presentation
January 18, 2018
Platform 1
Nicotine biosynthesis pathway: beyond tobacco
M Kajikawa*, N Sierro, H Kawaguchi*, N Bakaher, NV Ivanov, T Hashimoto*, T Shoji*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 13, 2017
Exploring the microbiome in health and disease: Implications for toxicology
E Scotti, S Boue, G Lo Sasso, F Zanetti, V Belcastro, C Poussin, N Sierro, JND Battey, A Gimalac, NV Ivanov, J Hoeng
Toxicology Research and Application
DOI : 10.1177/2397847317741884
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Poster
December 5, 2017
Platform 1
Systems Toxicology meta-analysis: Impact of a candidate Modified-Risk Tobacco Product aerosol compared with cigarette smoke on organotypic aerodigestive tract cultures
A Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
September 28, 2017
Platform 1
Comparative effects of a candidate modified-risk tobacco product aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach
A Iskandar, Y Martinez, F Martin, W Schlage, P Leroy, A Sewer, L Ortega Torres, S Majeed, C Merg, K Trivedi, E Guedj, S Frentzel, C Mathis, NV Ivanov, M Peitsch, J Hoeng
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Poster
September 28, 2017
Platform 1
Exposure to Cigarette Smoke and Aerosol from the Candidate Modified Risk Tobacco Product THS2.2 on A/J Mice in a Life-Time Inhalation Study
E T Wong, K Luettich, E Guedj, R Dulize, C Nury, B Titz, P Leroy, G Vuillaume, A Elamin, NV Ivanov, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 22, 2017
Platform 1
Proteomics as Part of a Multi-Omics Systems Toxicological Assessment of a Mentholated Candidate Modified Risk Tobacco Product
C Nury, U Kogel, B Titz, W Schlage, F Martin, A Oviedo, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 22, 2017
Platform 1
Integration of Targeted Proteomics into Systems Toxicology Approach: Candidate Modified-Risk Tobacco Product Assessment using Nasal Cultures
T Schneider, A Elamin, A Iskandar, F Zanetti, C Merg, A Sewer, B Titz, P Leroy, E Guedj, S Majeed, L Ortega Torres, W Schlage, C Mathis, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
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Poster
September 22, 2017
Heated Tobacco Products
Quantitative Proteomics to Investigate the Effects of a Prototype Modified Risk Tobacco Product (pMRTP) and Smoking Cessation on Mouse Lung Proteome.
S Dijon, A Elamin, B Titz, C Merg, M Geertz, T Schneider, F Martin, W Schlage, S Frentzel, F Talamo, E Veljkovic, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 20, 2017
Platform 1
Systems Toxicology Assessment of Repeated Exposure to Cigarette Smoke and a Candidate Modified-Risk Tobacco Product Aerosol on Gingival Organotypic Cultures
F Zanetti, A Sewer, P Leroy, S Majeed, L Ortega Torres, C Merg, M Corciulo, K Trivedi, E Guedj, A Elamin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
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Poster
September 20, 2017
Platform 1
Systems Toxicology Meta-Analysis: Impact of a Candidate Modified-Risk Tobacco Product Aerosol compared with Cigarette Smoke on Organotypic Aerodigestive Tract Cultures
A Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
September 5, 2017
Platform 4
Toxicity of the Main Electronic Cigarette Components, Propylene Glycol, Glycerin, and Nicotine, in Sprague-Dawley Rats in a 90-Day OECD Inhalation Study Complemented by Molecular Endpoints
B Phillips, B Titz, U Kogel, D Sharma, P Leroy, Y Xiang, G Vuillaume, S Lebrun, D Sciuscio, J Ho, C Nury, E Guedj, A Elamin, M Esposito, AS Krishnan *, W Schlage, E Veljkovic, NV Ivanov, F Martin, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Poster
September 4, 2017
Platform 1
In Vitro Systems Toxicology Assessment of Exposure to Aerosol from a Carbon Heated Tobacco Product as Compared with Exposure to Cigarette Smoke: The Impact on Nasal and Small Airway Epithelial Cultures
A Iskandar, Y Martinez, C Mathis, P Leroy, F Martin, A Sewer, L Ortega Torres, S Majeed, K Trivedi, S Frentzel, E Guedj, C Merg, A Elamin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
June 14, 2017
Platform 1
Systems Biology: Methods and Applications
B Titz, A Knorr, A Sewer, F Martin, NV Ivanov, M Talikka, I Gonzalez-Suarez, M Peitsch, J Hoeng
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
Pages 434–480
DOI : 10.1016/B978-0-12-409547-2.12333-9
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Peer-Reviewed Publication
May 29, 2017
Platform 1
Systems Toxicology Meta-Analysis of In Vitro Assessment Studies: Biological Impact of a Candidate Modified-Risk Tobacco Product Aerosol Compared with Cigarette Smoke on Human Organotypic Cultures of the Aerodigestive Tract
A Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, J Hoeng, M Peitsch
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Peer-Reviewed Publication
March 3, 2017
Platform 4
In Vitro Systems Toxicology Assessment of Nonflavored e-Cigarette Liquids in Primary Lung Epithelial Cells
I Gonzalez-Suarez, D Marescotti, F Martin, E Scotti, E Guedj, S Acali, R Dulize, K Baumer, D Peric, S Frentzel, NV Ivanov, J Hoeng, M Peitsch
DOI : 10.1089/aivt.2016.0040
