About Nikolai
I lead a research technology department that comprises state-of-the-art experimental and in silico labs generating and handling omics and histological data.
Latest Publications
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Peer-Reviewed Publication
September 24, 2021
Assessment of in vitro kinetics and biological impact of nebulized trehalose on human bronchial epithelium
A Iskandar, AR Kolli, A Giralt, L Neau, M. Fatarova, A Kondylis, L Ortega Torres, S Majeed, C Merg, M Corciulo, K Trivedi, E Guedj, S Frentzel, F Calvino, P A. Guy*, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2021.112577
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Publication
July 27, 2021
Platform 1
Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro
C Poussin, M Van der Toorn, S Scheuner, R Piault, A Kondylis, R Savioz*, R Dulize, D Peric, E Guedj, F Maranzano, C Merg, M Morelli, A L Egesipe, S Johne, S Majeed, C Pak, T Schneider, W Schlage, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1007/s00204-021-03123-y
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Peer-Reviewed Publication
July 2, 2021
Platform 1
Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract
JND Battey, J Szostak, B Phillips, C Teng, CK Tung, WT Lim, YS Yeo, S Ouadi, K Baumer, J Thomas, J Martinis , N Sierro, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.3389/fmicb.2021.587745
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Peer-Reviewed Publication
May 7, 2021
Platform 4
A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract
E T Wong, J Szostak, B Titz, T Lee, S K Wong, O Lavrynenko, C Merg, M Corciulo, J Simicevic, M Auberson, D Peric, R Dulize, D Bornand, G Loh, KM Lee*, J Zhang*, J Miller IV, W Schlage, E Guedj, T Schneider, B Phillips, P Leroy, MA Choukrallah, N Sierro, A Buettner*, Y Xiang, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1007/s00204-021-03020-4
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Publication
March 15, 2021
Platform 4
A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysematous changes following smoking cessation or switching to e-vapor products
K Ashutosh*, U Kogel, M Talikka, C Merg, E Guedj, Y Xiang, A Kondylis, B Titz, NV Ivanov, J Hoeng, M Peitsch, J Allen*, A Gupta *, A Skowronek*, K M Lee*
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177%2F2397847321995875
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Research
February 3, 2021
Impact of whole-body versus nose-only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE -/- mouse model
U Kogel, E T Wong, J Szostak, W Teck Tan, P Leroy, F Lucci, B Titz, Y Xiang, T Low, S K Wong, E Guedj, NV Ivanov, W Schlage, M Peitsch, A Kuczaj, P Vanscheeuwijck, J Hoeng
DOI : 10.1002/jat.4149
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Book Chapter
January 18, 2021
Toxicological Evaluation of Electronic Nicotine Delivery Products
F Zanetti, W Xia, E T Wong, P Vanscheeuwijck, M Van der Toorn, B Titz, M Talikka, J Szostak, M Smith, D Smart, D Sciuscio, W Schlage, JP Schaller, R Savioz*, P Pratte, C Poussin, S Pouly, P Picavet, B Phillips, M Peck, M Mitova, D McHugh, A May*, C Mathis, F Martin, D Marescotti, S Maeder, K Luettich, F Lucci, A Kuczaj, AR Kolli, U Kogel, NV Ivanov, A Iskandar, C Haziza, C Goujon-Ginglinger, S Frentzel, M Firestone , MA Choukrallah, D Bovard, S Boue, M Bentley, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
November 18, 2020
Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures
A Giralt, A Iskandar, F Martin, E Moschini*, T Serchi*, A Kondylis, D Marescotti, P Leroy, L Ortega Torres, S Majeed, C Merg, K Trivedi, E Guedj, S Frentzel, NV Ivanov, M Peitsch, AC Gutleb*, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.toxlet.2020.11.006
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Peer-Reviewed Publication
November 12, 2020
Platform 1
Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies
O Lavrynenko, B Titz, S Dijon, D Dos Santos , C Nury, T Schneider, E Guedj, J Szostak, A Kondylis, B Phillips, K Ekroos*, F Martin, M Peitsch, J Hoeng, NV Ivanov
* This author is not affiliated with PMI.DOI : 10.1016/j.lfs.2020.118753
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Peer-Reviewed Publication
October 29, 2020
Heated Tobacco Products
Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity
A van der Plas, S Pouly, N Blanc, C Haziza, G de La Bourdonnaye, B Titz, J Hoeng, NV Ivanov, BV Taranu, A Heremans
DOI : 10.1016/j.toxrep.2020.10.017
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Poster
October 19, 2020
Nicotine-Containing E-Vapor Products
Plasma Protein Biomarker Identification for Monitoring Molecular Changes in Smokers, Former Smokers, and E-Vapor Product Users Compared with Never Smokers
C Nury, Y Eb-Levadoux, AR Kolli, C Poussin, TM Curran*, LA Baglia*, RA Berg*, Loyse Felber Medlin , S Ansari, E Kishazi, F Martin, B Titz, P Picavet, NV Ivanov, SL Spinelli*, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Poster
October 4, 2020
Heated Tobacco Products
Assessing the impact of switching to the Tobacco Heating System on cardiovascular diseases: Translating basic science into clinical benefit
G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Luedicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch, C Pater
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Poster
September 17, 2020
Heated Tobacco Products
Compilation of in vitro studies evaluating the impact of exposure to aerosols from heated tobacco products and an electronic vapor device on oral health and dental esthetics.
F Zanetti, A Nussbaum, A Iskandar, X Zhao, Y Ren*, S Majeed, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
September 12, 2020
A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products
A Sewer, F Zanetti, A Iskandar, E Guedj, R Dulize, D Peric, D Bornand, C Mathis, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2020.09.001
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Peer-Reviewed Publication
September 12, 2020
Heated Tobacco Products
Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case
W Schlage, B Titz, A Iskandar, C Poussin, M Van der Toorn, E T Wong, P Pratte, S Maeder, JP Schaller, P Pospisil, S Boue, G Vuillaume, P Leroy, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2020.09.004
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Peer-Reviewed Publication
August 24, 2020
Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis
P A Ruiz Castro, U Kogel, G Lo Sasso, B Phillips, A Sewer, B Titz, L Garcia, A Kondylis, E Guedj, D Peric, D Bornand, R Dulize, C Merg, M Corciulo, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1186/s12950-020-00260-6
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Peer-Reviewed Publication
August 11, 2020
Heated Tobacco Products
Respiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice
B Titz, A Sewer, K Luettich, E T Wong, E Guedj, C Nury, T Schneider, Y Xiang, K Trivedi, G Vuillaume, P Leroy, A Buettner*, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfaa132
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Peer-Reviewed Publication
August 7, 2020
Inflammatory Bowel Disease–Associated Changes in the Gut: Focus on Kazan Patients
G Lo Sasso, L Khachatryan, A Kondylis, JND Battey, N Sierro, NA Danilova*, TV Grigoryeva*, MI Markelova*, DR Khusnutdinova*, AV Laikov*, II Salafutdinov*, YD Romanova*, MN Siniagina*, IY Vasiliev*, EA Boulygina*, VV Solovyeva*, EE Garanina*, KV Kitaeva*, KY Ivanov*, DS Chulpanova*, KS Kletenkov*, AR Valeeva*, A Kh Odintsova*, MD Ardatskaya*, RA Abdulkhakov*, NV Ivanov, M Peitsch, J Hoeng, SR Abdulkhakov*
* This author is not affiliated with PMI.DOI : 10.1093/ibd/izaa188
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Peer-Reviewed Publication
July 14, 2020
Metabolic networks of the Nicotiana genus in the spotlight: content, progress and outlook
H Foerster*, JND Battey, N Sierro, NV Ivanov, LA Mueller*
* This author is not affiliated with PMI.DOI : 10.1093/bib/bbaa136
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Poster
July 12, 2020
Heated Tobacco Products
Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Disease: Translating Basic Science into Clinical Benefit
G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch
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Peer-Reviewed Publication
June 10, 2020
Heated Tobacco Products
Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GC–MS deconvolution procedures
A Haiduc, F Zanetti, X Zhao, W Schlage, M Scherer*, N Pluym*, P Schlenger*, NV Ivanov, S Majeed, J Hoeng, M Peitsch, Y Ren*, P A. Guy*
* This author is not affiliated with PMI.DOI : 10.1016/j.jchromb.2020.122228
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Peer-Reviewed Publication
June 8, 2020
Alkaloid chemophenetics and transcriptomics of the Nicotiana genus
K P. Kaminski, L Bovet, H Laparra, G Lang, D De Palo, N Sierro, S Goepfert, NV Ivanov
DOI : 10.1016/j.phytochem.2020.112424
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Poster
June 1, 2020
Monitoring of exogenous compound kinetics in exhaled breath
T Zikovic Semren, C Laszlo, M Gomez*, G Vidal-de-Miguel*, J Hoeng, M Peitsch, NV Ivanov, P A. Guy*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
May 5, 2020
Nicotine-Containing E-Vapor Products
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis
J Ho, D Sciuscio, U Kogel, B Titz, P Leroy, G Vuillaume, M Talikka, E Martin, P Pospisil, S Lebrun, W Xia, T Lee, Y X Chng, B Phillips, E Veljkovic, E Guedj, Y Xiang, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
DOI : 10.1007/s00204-020-02759-6
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Peer-Reviewed Publication
April 27, 2020
Phage T7 DNA mimic protein Ocr is a potent inhibitor of BREX defence
A Isaev*, A Drobiazko*, N Sierro, J Gordeeva*, I Yosef*, U Qimron*, NV Ivanov, K Severinov*
* This author is not affiliated with PMI.DOI : 10.1093/nar/gkaa290
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Peer-Reviewed Publication
April 25, 2020
Heated Tobacco Products
Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
B Titz, J Szostak, A Sewer, B Phillips, C Nury, T Schneider, S Dijon, O Lavrynenko, A Elamin, E Guedj, E T Wong, S Lebrun, G Vuillaume, A Kondylis, S Gubian, S Cano, P Leroy, NV Ivanov, P Vanscheeuwijck, F Martin, M Peitsch, J Hoeng
Computational and Structural Biotechnology Journal
DOI : 10.1016/j.csbj.2020.04.011
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Peer-Reviewed Publication
April 25, 2020
Lipid-based biomarkers for CVD, COPD, and aging – A translational perspective
K Ekroos*, O Lavrynenko, B Titz, C Pater, J Hoeng, NV Ivanov
* This author is not affiliated with PMI.DOI : 10.1016/j.plipres.2020.101030
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Peer-Reviewed Publication
January 24, 2020
Nicotine-Containing E-Vapor Products
A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke
J Szostak, E T Wong, B Titz, T Lee, S K Wong, T Low, KM Lee*, J Zhang*, K Ashutosh*, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, Y Xiang, F Martin, A Sewer, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.American Journal of Physiology - Heart and Circulatory Physiology
DOI : 10.1152/ajpheart.00613.2019
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Presentation
December 10, 2019
Nicotine-Containing E-Vapor Products
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology
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Poster
December 10, 2019
3D human microvessel-on-a-chip model for studying monocyte-endothelial adhesion under flow - application in systems toxicology
C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
November 25, 2019
Nicotine-Containing E-Vapor Products
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2019.11.016
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Peer-Reviewed Publication
November 6, 2019
Heated Tobacco Products
Structural, functional, and molecular impact on the cardiovascular system in ApoE−/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke
J Szostak, B Titz, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, L Neau, K Trivedi, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Chemico-Biological Interactions
DOI : 10.1016/j.cbi.2019.108887
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Peer-Reviewed Publication
September 7, 2019
Nicotine-Containing E-Vapor Products
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology
A Iskandar, F Zanetti, D Marescotti, B Titz, A Sewer, A Kondylis, P Leroy, V Belcastro, L Ortega Torres, S Acali, S Majeed, S Steiner, K Trivedi, E Guedj, C Merg, T Schneider, S Frentzel, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1007/s00204-019-02565-9
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Peer-Reviewed Publication
August 22, 2019
Heated Tobacco Products
3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow – application in systems toxicology
C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI.DOI : 10.14573/altex.1811301
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Peer-Reviewed Publication
July 3, 2019
Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties
S Schorderet Weber, K P. Kaminski, JL Perret*, P Leroy, A Mazurov, M Peitsch, NV Ivanov, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.110660
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Poster
June 24, 2019
Untargeted Metabolomics Application to Monitor Urine Samples by Ultra-High-Pressure Liquid Chromatography Coupled to High-Resolution Mass Spectrometry
C Laszlo, A G Haiduc, M. Fatarova, E Dossin, F. de Jong*, C. Beecher*, A. Kamleh*, P Guy, NV Ivanov, M Peitsch
* This author is not affiliated with PMI. -
Poster
June 24, 2019
Prediction models of retention indices: application to gas chromatography coupled to high-resolution mass spectrometry for two column types: DB-624 and HP-5ms
A G Haiduc, E Dossin, P Diana, P Guy, NV Ivanov, M Peitsch
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Publication
March 26, 2019
Heated Tobacco Products
A meta-analysis of the performance of a blood-based exposure response gene signature across clinical studies on the Tobacco Heating System 2.2 (THS 2.2)
F Martin, M Talikka, NV Ivanov, C Haziza, J Hoeng, M Peitsch
DOI : 10.3389/fphar.2019.00198
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Peer-Reviewed Publication
March 18, 2019
Nicotine-Containing E-Vapor Products
Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
KM Lee*, J Hoeng, S Harbo*, U Kogel, W Gardner*, M J Oldham*, E Benson*, M Talikka, A Kondylis, F Martin, B Titz, S Ansari, K Trivedi, E Guedj, A Elamin, NV Ivanov, P Vanscheeuwijck, M Peitsch, WJ McKinney*
* This author is not affiliated with PMI.DOI : 10.1080/08958378.2019.1576807
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Peer-Reviewed Publication
March 18, 2019
GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology
V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1093/bioinformatics/btz187
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Presentation
March 16, 2019
Platform 1
Cardiovascular Effects of the Tobacco Heating System (THS) Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, C Poussin, P Vanscheeuwijck
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Poster
March 12, 2019
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, K Baumer, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, K Luettich, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
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Poster
March 12, 2019
Heated Tobacco Products
Xenobiotic metabolism response to 3R4F or THS2.2 exposure: from pre-clinical to clinical
S Pouly, M Talikka, A van der Plas, B Titz, A Iskandar, G de La Bourdonnaye, N Blanc, F Martin, C Haziza, NV Ivanov, F Lüdicke, J Hoeng, M Peitsch
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Publication
March 12, 2019
Nicotine-Containing E-Vapor Products
Exposure to an aerosol from a novel electronic cigarette using the MESH™ technology elicited reduced biological impacts than exposure to cigarette smoke on buccal and small airway epithelial cultures: a systems toxicology assessment
A Iskandar, F Zanetti, A Kondylis, F Martin, A Sewer, L Ortega Torres, S Majeed, S Steiner, E Guedj, C Merg, T Schneider, K Trivedi, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
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Poster
March 12, 2019
GladiaTOX: global assessment of dose-response indicators in toxicology
V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng
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Publication
March 12, 2019
Nicotine-Containing E-Vapor Products
Comparison of the impacts of an acute exposure to electronic cigarette aerosol and cigarette smoke on small airway epithelial cultures: In vitro systems toxicology assessment
A Iskandar, A Kondylis, F Martin, S Steiner, S Majeed, P Leroy, E Guedj, C Merg, K Trivedi, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
March 5, 2019
Platform 4
A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment
A Iskandar, F Zanetti, A Kondylis, F Martin, P Leroy, S Majeed, S Steiner, Y Xiang, L Ortega Torres, K Trivedi, E Guedj, C Merg, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Internal and Emergency Medicine
DOI : 10.1007/s11739-019-02055-x
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Poster
February 28, 2019
Platform 1
Chronic Toxicity and Lung Carcinogenicity in A/J Mice Following Lifetime Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
K Luettich, E T Wong, K Trivedi, E Guedj, T Schneider, C Nury, B Titz, Y Xiang, P Leroy, G Vuillaume, P Vanscheeuwijck, NV Ivanov, M Peitsch, J Hoeng