About Patrick
I am responsible for the experimental biology aspects of the standard toxicological assessment of Reduced-Risk Products (RRPs). I lead the in vitro and in vivo laboratories performing Good Laboratory Practice studies to characterize the hazard associated with the aerosols from RRPs in comparison to conventional cigarette smoke.
Latest Publications
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Peer-Reviewed Publication
May 7, 2021
Platform 4
A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract
E T Wong, J Szostak, B Titz, T Lee, S K Wong, O Lavrynenko, C Merg, M Corciulo, J Simicevic, M Auberson, D Peric, R Dulize, D Bornand, G Loh, KM Lee*, J Zhang*, J Miller IV, W Schlage, E Guedj, T Schneider, B Phillips, P Leroy, MA Choukrallah, N Sierro, A Buettner*, Y Xiang, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1007/s00204-021-03020-4
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Peer-Reviewed Publication
March 11, 2021
Platform 1
In Vivo Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy
W Xia, AR Kolli, K Koshibu, F Martin, A Kondylis, A Kuczaj, W Teck Tan, YS Yeo, G Tan, C Teng, K Woon , T Schneider, M Talikka, B Phillips, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1021/acs.jnatprod.0c01044
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Research
February 3, 2021
Impact of whole-body versus nose-only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE -/- mouse model
U Kogel, E T Wong, J Szostak, W Teck Tan, P Leroy, F Lucci, B Titz, Y Xiang, T Low, S K Wong, E Guedj, NV Ivanov, W Schlage, M Peitsch, A Kuczaj, P Vanscheeuwijck, J Hoeng
DOI : 10.1002/jat.4149
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Book Chapter
January 18, 2021
Toxicological Evaluation of Electronic Nicotine Delivery Products
F Zanetti, W Xia, E T Wong, P Vanscheeuwijck, M Van der Toorn, B Titz, M Talikka, J Szostak, M Smith, D Smart, D Sciuscio, W Schlage, JP Schaller, R Savioz*, P Pratte, C Poussin, S Pouly, P Picavet, B Phillips, M Peck, M Mitova, D McHugh, A May*, C Mathis, F Martin, D Marescotti, S Maeder, K Luettich, F Lucci, A Kuczaj, AR Kolli, U Kogel, NV Ivanov, A Iskandar, C Haziza, C Goujon-Ginglinger, S Frentzel, M Firestone , MA Choukrallah, D Bovard, S Boue, M Bentley, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 29, 2020
Platform 3
State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products
S Boue, D Goedertier, J Hoeng, A Iskandar, A Kuczaj, D Marescotti, C Mathis, A May*, B Phillips, M Peitsch, W Schlage, D Sciuscio, W Teck Tan, P Vanscheeuwijck
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177/2397847320979751
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Presentation
December 9, 2020
Platform 3
Comparative Assessment of Pharmacokinetics and Acute Lung Inflammation of Nicotine Dry Powder Aerosols Generated by PreciseInhale®
S Lam, R Ng, B Phillips, W Teck Tan, C Teng, C Wong, R Piault, C Merg, D Sciuscio, J Hoeng, P Vanscheeuwijck
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Poster
October 4, 2020
Heated Tobacco Products
Assessing the impact of switching to the Tobacco Heating System on cardiovascular diseases: Translating basic science into clinical benefit
G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Luedicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch, C Pater
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Peer-Reviewed Publication
August 11, 2020
Heated Tobacco Products
Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol from a Heated Tobacco Product Compared with Cigarette Smoke
E T Wong, K Luettich, S Krishnan, S K Wong, WT Lim, D Yeo, A Buettner*, P Leroy, G Vuillaume, S Boue, J Hoeng, P Vanscheeuwijck, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfaa131
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Peer-Reviewed Publication
August 11, 2020
Heated Tobacco Products
Respiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice
B Titz, A Sewer, K Luettich, E T Wong, E Guedj, C Nury, T Schneider, Y Xiang, K Trivedi, G Vuillaume, P Leroy, A Buettner*, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfaa132
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Poster
July 12, 2020
Heated Tobacco Products
Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Disease: Translating Basic Science into Clinical Benefit
G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch
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Peer-Reviewed Publication
May 5, 2020
Nicotine-Containing E-Vapor Products
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis
J Ho, D Sciuscio, U Kogel, B Titz, P Leroy, G Vuillaume, M Talikka, E Martin, P Pospisil, S Lebrun, W Xia, T Lee, Y X Chng, B Phillips, E Veljkovic, E Guedj, Y Xiang, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
DOI : 10.1007/s00204-020-02759-6
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Peer-Reviewed Publication
April 25, 2020
Heated Tobacco Products
Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
B Titz, J Szostak, A Sewer, B Phillips, C Nury, T Schneider, S Dijon, O Lavrynenko, A Elamin, E Guedj, E T Wong, S Lebrun, G Vuillaume, A Kondylis, S Gubian, S Cano, P Leroy, NV Ivanov, P Vanscheeuwijck, F Martin, M Peitsch, J Hoeng
Computational and Structural Biotechnology Journal
DOI : 10.1016/j.csbj.2020.04.011
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Poster
March 3, 2020
Nicotine-Containing E-Vapor Products
A structure-based grouping approach for evaluating the toxicity of e-cigarette flavor ingredients: A 5-week inhalation study in A/J mice
D Sciuscio, K Ashutosh*, P Leroy, A Nussbaum, K M Lee*, P Vanscheeuwijck, E T Wong, M Peitsch, K Luettich, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
January 24, 2020
Nicotine-Containing E-Vapor Products
A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke
J Szostak, E T Wong, B Titz, T Lee, S K Wong, T Low, KM Lee*, J Zhang*, K Ashutosh*, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, Y Xiang, F Martin, A Sewer, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.American Journal of Physiology - Heart and Circulatory Physiology
DOI : 10.1152/ajpheart.00613.2019
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Peer-Reviewed Publication
January 21, 2020
Platform 1
State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-not-burn tobacco products
S Boue, D Goedertier, J Hoeng, A Kuczaj, S Majeed, C Mathis, A May*, B Phillips, M Peitsch, F Radtke, W Schlage, W Teck Tan, P Vanscheeuwijck
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177/2397847319897869
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Peer-Reviewed Publication
December 27, 2019
Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro
D Smart, FR Helbling, M Verardo, A Huber, D McHugh, P Vanscheeuwijck
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
DOI : 10.1016/j.mrgentox.2019.503129
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Peer-Reviewed Publication
December 1, 2019
Nicotine-Containing E-Vapor Products
Baseline effects of non-flavored e-liquids in the in vitro micronucleus assay
D Smart, FR Helbling, D McHugh, P Vanscheeuwijck
Toxicology Research and Application
DOI : 10.1177/2397847319887904
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Peer-Reviewed Publication
November 22, 2019
Experimental and computational investigation of a nose-only exposure chamber
F Lucci, W Teck Tan, S Krishnan, J Hoeng, P Vanscheeuwijck, R Jaeger*, A Kuczaj
* This author is not affiliated with PMI.Aerosol Science and Technology
DOI : 10.1080/02786826.2019.1687843
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Peer-Reviewed Publication
November 6, 2019
Heated Tobacco Products
Structural, functional, and molecular impact on the cardiovascular system in ApoE−/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke
J Szostak, B Titz, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, L Neau, K Trivedi, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Chemico-Biological Interactions
DOI : 10.1016/j.cbi.2019.108887
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Peer-Reviewed Publication
September 10, 2019
Nicotine-Containing E-Vapor Products
Lysosomotropic-related limitations of the BALB/c 3T3 cell-based neutral red uptake assay and an alternative testing approach for assessing e-liquid cytotoxicity
G Cudazzo, D Smart, D McHugh, P Vanscheeuwijck
DOI : 10.1016/j.tiv.2019.104647
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Peer-Reviewed Publication
September 9, 2019
Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles
DOI : 10.1080/08958378.2019.1662526
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Poster
August 27, 2019
Evaluation of a small whole-body exposure chamber for mice
W Teck Tan, S Krishnan, B Phillips, A Kuczaj, J Hoeng, P Vanscheeuwijck
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Peer-Reviewed Publication
July 11, 2019
Mode‐of‐action analysis of the effects induced by nicotine in the in vitro micronucleus assay
D Smart, FR Helbling, M Verardo, D McHugh, P Vanscheeuwijck
Environmental and Molecular Mutagenesis
DOI : 10.1002/em.22314
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Report
March 20, 2019
Platform 1
Summary of Evidence of Effects of IQOS on Endothelial function
G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch
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Peer-Reviewed Publication
March 18, 2019
Nicotine-Containing E-Vapor Products
Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
KM Lee*, J Hoeng, S Harbo*, U Kogel, W Gardner*, M J Oldham*, E Benson*, M Talikka, A Kondylis, F Martin, B Titz, S Ansari, K Trivedi, E Guedj, A Elamin, NV Ivanov, P Vanscheeuwijck, M Peitsch, WJ McKinney*
* This author is not affiliated with PMI.DOI : 10.1080/08958378.2019.1576807
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Presentation
March 16, 2019
Platform 1
Cardiovascular Effects of the Tobacco Heating System (THS) Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, C Poussin, P Vanscheeuwijck
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Poster
March 16, 2019
Physiologically based Pharmacokinetic Modeling of Nicotine from Inhaled Aqueous Aerosol Predicts Marked Gastrointestinal Absorption in Rats
AR Kolli, F Martin, Y Xiang, B Titz, E T Wong, W Schlage, E Veljkovic, P Vanscheeuwijck, J Hoeng
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Poster
February 28, 2019
Platform 1
Chronic Toxicity and Lung Carcinogenicity in A/J Mice Following Lifetime Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
K Luettich, E T Wong, K Trivedi, E Guedj, T Schneider, C Nury, B Titz, Y Xiang, P Leroy, G Vuillaume, P Vanscheeuwijck, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
February 14, 2019
Platform 1
Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products
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Peer-Reviewed Publication
February 12, 2019
Heated Tobacco Products
A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes
B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, C Teng, CK Tung, YS Yeo, P Vanscheeuwijck, M Peitsch, J Hoeng, WT Lim
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.02.008
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Report
December 10, 2018
Platform 1
Summary of Evidence: Cytotoxic Effects on Bronchial Epithelial Cells
G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch
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Poster
December 3, 2018
Platform 1
Toxicological evaluation of the Tobacco Heating System 2.2, a candidate modified risk tobacco product in a OECD inhalation study complemented with systems toxicology
U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, P Vanscheeuwijck, J Hoeng, M Peitsch
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Report
November 20, 2018
Platform 1
Summary of the Evidence: Pulmonary and Immunosuppressive Effects of IQOS
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Presentation
October 29, 2018
Alternatives to cytotoxicity assessment of eliquids using the neutral red uptake assay
D McHugh, G Cudazzo, P Vanscheeuwijck
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Poster
October 5, 2018
Platform 1
Systems toxicology assessment of potential modified risk tobacco products: effects on lung, liver, and heart in ApoE -/- mice using iTRAQ
C Nury, B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
September 21, 2018
Platform 1
Lung Inflammation, Emphysema, and Lung Cancer Development in A/J mice in Response to Chronic Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, B Titz, P Leroy, G Vuillaume, B Phillips, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 17, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Poster
September 10, 2018
Characterization of the Aerosol Flow, Sampling, and Deposition in a Nose Only Exposure Chamber
F Lucci, W Teck Tan, S Krishnan, J Hoeng, P Vanscheeuwijck, R Jaeger*, A Kuczaj
* This author is not affiliated with PMI. -
Presentation
September 10, 2018
A novel method for multi-component continuous real-time aerosol monitoring using Fourier Transformed Infrared (FTIR) spectroscopy for in vivo studies
W Teck Tan, AS Krishnan *, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Poster
September 10, 2018
Fourier Transformed Infrared (FTIR) Method For Continuous Real-Time Aerosol Characterization For In Vivo Studies
W Teck Tan, AS Krishnan *, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Poster
September 6, 2018
Platform 1
Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Two Reduced-Risk Products Compared with Conventional Cigarettes
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
June 25, 2018
Platform 1
The impact of aerosol from Carbon Heated Tobacco Product 1.2 compared with cigarette smoke on the cardiovascular system of ApoE-/- mice in a six-month inhalation study
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
June 11, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Poster
May 9, 2018
Platform 1
Systems Toxicological Assessment of two Modified Risk Tobacco Products on Cardiovascular and Respiratory Effects in ApoE-/-mice - a six-month inhalation study
B Phillips, J Szostak, E Guedj, E T Wong, M Talikka, S Lebrun, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
May 5, 2018
Platform 4
Establishing the baseline effects of non-flavoured e-liquids and flavour compounds in the in vitro micronucleus assay
D Smart, P Vanscheeuwijck, D McHugh, E Nallet, FR Helbling
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Poster
May 5, 2018
Mode-of-action analysis of a positive in vitro micronucleus finding in CHO-WBL cells
D McHugh, P Vanscheeuwijck, FR Helbling, D Smart
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Peer-Reviewed Publication
April 11, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology
B Phillips, W Schlage, B Titz, U Kogel, D Sciuscio, F Martin, P Leroy, G Vuillaume, AS Krishnan *, PN Lee*, E Veljkovic, A Elamin, C Merg, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2018.04.015
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Peer-Reviewed Publication
March 13, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment
B Titz, U Kogel, F Martin, W Schlage, Y Xiang, C Nury, S Dijon, K Baumer, D Peric, D Bornand, R Dulize, B Phillips, P Leroy, G Vuillaume, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.058
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Poster
November 20, 2017
Platform 1
Genetic and Cell Toxicology In Vitro Assessment of Potentially Reduced Risk Products for Smokers
D McHugh, D Smart, G Cudazzo, P Vanscheeuwijck