About Patrick
I am responsible for the experimental biology aspects of the standard toxicological assessment of Reduced-Risk Products (RRPs). I lead the in vitro and in vivo laboratories performing Good Laboratory Practice studies to characterize the hazard associated with the aerosols from RRPs in comparison to conventional cigarette smoke.
Latest Publications
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Report
December 10, 2018
Platform 1
Summary of Evidence: Cytotoxic Effects on Bronchial Epithelial Cells
G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch
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Poster
December 3, 2018
Platform 1
Toxicological evaluation of the Tobacco Heating System 2.2, a candidate modified risk tobacco product in a OECD inhalation study complemented with systems toxicology
U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, P Vanscheeuwijck, J Hoeng, M Peitsch
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Report
November 20, 2018
Platform 1
Summary of the Evidence: Pulmonary and Immunosuppressive Effects of IQOS
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Presentation
October 29, 2018
Alternatives to cytotoxicity assessment of eliquids using the neutral red uptake assay
D McHugh, G Cudazzo, P Vanscheeuwijck
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Poster
October 5, 2018
Platform 1
Systems toxicology assessment of potential modified risk tobacco products: effects on lung, liver, and heart in ApoE -/- mice using iTRAQ
C Nury, B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, A Choukrallah, T Schneider, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
September 21, 2018
Platform 1
Lung Inflammation, Emphysema, and Lung Cancer Development in A/J mice in Response to Chronic Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, B Titz, P Leroy, G Vuillaume, B Phillips, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 17, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Poster
September 10, 2018
Characterization of the Aerosol Flow, Sampling, and Deposition in a Nose Only Exposure Chamber
F Lucci, W Teck Tan, S Krishnan, J Hoeng, P Vanscheeuwijck, R Jaeger*, A Kuczaj
* This author is not affiliated with PMI. -
Presentation
September 10, 2018
A novel method for multi-component continuous real-time aerosol monitoring using Fourier Transformed Infrared (FTIR) spectroscopy for in vivo studies
W Teck Tan, AS Krishnan *, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Poster
September 10, 2018
Fourier Transformed Infrared (FTIR) Method For Continuous Real-Time Aerosol Characterization For In Vivo Studies
W Teck Tan, AS Krishnan *, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Poster
September 6, 2018
Platform 1
Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Two Reduced-Risk Products Compared with Conventional Cigarettes
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
June 25, 2018
Platform 1
The impact of aerosol from Carbon Heated Tobacco Product 1.2 compared with cigarette smoke on the cardiovascular system of ApoE-/- mice in a six-month inhalation study
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
June 11, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Poster
May 9, 2018
Platform 1
Systems Toxicological Assessment of two Modified Risk Tobacco Products on Cardiovascular and Respiratory Effects in ApoE-/-mice - a six-month inhalation study
B Phillips, J Szostak, E Guedj, E T Wong, M Talikka, S Lebrun, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
May 5, 2018
Platform 4
Establishing the baseline effects of non-flavoured e-liquids and flavour compounds in the in vitro micronucleus assay
D Smart, P Vanscheeuwijck, D McHugh, E Nallet, FR Helbling
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Poster
May 5, 2018
Mode-of-action analysis of a positive in vitro micronucleus finding in CHO-WBL cells
D McHugh, P Vanscheeuwijck, FR Helbling, D Smart
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Peer-Reviewed Publication
April 11, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology
B Phillips, W Schlage, B Titz, U Kogel, D Sciuscio, F Martin, P Leroy, G Vuillaume, AS Krishnan *, PN Lee*, E Veljkovic, A Elamin, C Merg, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2018.04.015
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Peer-Reviewed Publication
March 13, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment
B Titz, U Kogel, F Martin, W Schlage, Y Xiang, C Nury, S Dijon, K Baumer, D Peric, D Bornand, R Dulize, B Phillips, P Leroy, G Vuillaume, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.058
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Poster
November 20, 2017
Platform 1
Genetic and Cell Toxicology In Vitro Assessment of Potentially Reduced Risk Products for Smokers
D McHugh, D Smart, G Cudazzo, P Vanscheeuwijck
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Report
October 2, 2017
Platform 1
The Science behind the Tobacco Heating System -- A summary of published scientific articles
M Smith, C Haziza, J Hoeng, F Lüdicke, S Maeder, P Vanscheeuwijck, M Peitsch
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Poster
September 28, 2017
Platform 1
Exposure to Cigarette Smoke and Aerosol from the Candidate Modified Risk Tobacco Product THS2.2 on A/J Mice in a Life-Time Inhalation Study
E T Wong, K Luettich, E Guedj, R Dulize, C Nury, B Titz, P Leroy, G Vuillaume, A Elamin, NV Ivanov, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 22, 2017
Platform 1
Proteomics as Part of a Multi-Omics Systems Toxicological Assessment of a Mentholated Candidate Modified Risk Tobacco Product
C Nury, U Kogel, B Titz, W Schlage, F Martin, A Oviedo, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 22, 2017
Heated Tobacco Products
Quantitative Proteomics to Investigate the Effects of a Prototype Modified Risk Tobacco Product (pMRTP) and Smoking Cessation on Mouse Lung Proteome.
S Dijon, A Elamin, B Titz, C Merg, M Geertz, T Schneider, F Martin, W Schlage, S Frentzel, F Talamo, E Veljkovic, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
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Peer-Reviewed Publication
September 5, 2017
Platform 4
Toxicity of the Main Electronic Cigarette Components, Propylene Glycol, Glycerin, and Nicotine, in Sprague-Dawley Rats in a 90-Day OECD Inhalation Study Complemented by Molecular Endpoints
B Phillips, B Titz, U Kogel, D Sharma, P Leroy, Y Xiang, G Vuillaume, S Lebrun, D Sciuscio, J Ho, C Nury, E Guedj, A Elamin, M Esposito, AS Krishnan *, W Schlage, E Veljkovic, NV Ivanov, F Martin, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
September 5, 2017
Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure.
S Boue, T Exner*, D Ghosh, V Belcastro, J Dokler*, D Page, A Boda, F Bonjour, B Hardy*, P Vanscheeuwijck, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
November 4, 2016
Platform 1
Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke
U Kogel, B Titz, W Schlage, C Nury, F Martin, A Oviedo, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.11.001
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Peer-Reviewed Publication
November 3, 2016
Platform 1
Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke
A Oviedo, S Lebrun, U Kogel, J Ho, W Teck Tan, B Titz, P Leroy, G Vuillaume, M Bera, F Martin, G Rodrigo, M Esposito, R Dempsey, NV Ivanov, J Hoeng, M Peitsch, P Vanscheeuwijck
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.11.004
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Peer-Reviewed Publication
October 26, 2016
Platform 1
Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke
E T Wong, U Kogel, E Veljkovic, F Martin, Y Xiang, S Boue, G Vuillaume, P Leroy, E Guedj, G Rodrigo, NV Ivanov, J Hoeng, M Peitsch, P Vanscheeuwijck
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.10.015
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Peer-Reviewed Publication
October 6, 2016
Platform 1
Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol
JP Schaller, D Keller*, L Poget, P Pratte, E Kaelin, D McHugh, G Cudazzo, D Smart, A R Tricker, L Gautier, M Yerly, R Reis Pires , S Le Bouhellec, D Ghosh, I Hofer, E Garcia Fidalgo, P Vanscheeuwijck, S Maeder
* This author is not affiliated with PMI.Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.10.001
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Poster
September 9, 2016
Heated Tobacco Products
Performance of the flow cytometry-based in vitro micronucleus assay in a validation study
D Smart, FR Helbling, B Pouleau, D McHugh, P Vanscheeuwijck
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Presentation
September 9, 2016
Heated Tobacco Products
Toxicological characterization of the mentholated heat‐not‐burn product THS2.2M in a 90-day OECD inhalation study
A Oviedo, S Lebrun, J Ho, AS Krishnan *, W Teck Tan, G Vuillaume, P Leroy, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Poster
September 9, 2016
Heated Tobacco Products
Toxicity of aerosols of propylene glycol, vegetable glycerin and nicotine in Sprague-Dawley rats in a 90d OECD 413 sub-chronic inhalation study
B Phillips, D Sharma, D Sciuscio, E Veljkovic, S Lebrun, J Verbeeck, W Teck Tan, U Kogel, J Ho, G Vuillaume, P Leroy, J Hoeng, M Peitsch, P Vanscheeuwijck
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Poster
September 7, 2016
Heated Tobacco Products
Evaluation of the candidate modified risk tobacco product THS2.2 in a battery of in vitro genotoxicity and cytotoxicity tests
D McHugh, G Cudazzo, D Smart, D Keller*, P Vanscheeuwijck
* This author is not affiliated with PMI. -
Poster
September 7, 2016
Heated Tobacco Products
Genomic analysis of L5178Y tk+/- cells and their induced tk-/- mutant colonies
JND Battey, D Smart, N Sierro, D McHugh, P Vanscheeuwijck, M Peitsch, NV Ivanov
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Presentation
July 12, 2016
Heated Tobacco Products
Comparative Assessment of Lung Inflammation, Pulmonary Function and Emphysema Caused by the Aerosol from Potential Reduced Risk Products and Cigarette Smoke in Mouse Models of COPD
P Vanscheeuwijck, B Phillips, E T Wong, J Hoeng, M Peitsch
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Peer-Reviewed Publication
July 7, 2016
Platform 1
Evaluation of the Tobacco Heating System 2.2. part 1: Description of the system and the scientific assessment program
M Smith, B Clark, F Lüdicke, JP Schaller, P Vanscheeuwijck, J Hoeng, M Peitsch
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.07.006
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Presentation
June 18, 2016
Platform 1
Non‐Clinical Toxicology of Nicotine and Aerosol from a Heated Tobacco
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Poster
June 9, 2016
Platform 1
Effects of Cigarette Smoke, Cessation and Switching to Aerosol from Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in Two Mouse Strains
T Schneider, B Titz, S Boue, B Phillips, M Talikka, T Vihervaara*, C Nury, A Elamin, E Guedj, M Peck, W Schlage, M Cabanski, P Leroy, G Vuillaume, F Martin, NV Ivanov, E Veljkovic, K Ekroos*, R Laaksonen, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
June 5, 2016
Platform 2
Quantitative Proteomics Analysis Using 2D-PAGE to Investigate the Effects of Cigarette Smoke and Aerosol of a Prototypic Modified Risk Tobacco Product on the Lung Proteome in C57BL/6 Mice
A Elamin, B Titz, S Dijon, C Merg, M Geertz, T Schneider, F Martin, W Schlage, S Frentzel, F Talamo, B Phillips, E Veljkovic, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1016/j.jprot.2016.05.037
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Poster
June 5, 2016
Characterization of Aerosol Exposure, Metabolism and Pharmacokinetics for ToxicoLogical Assessment Using In Vitro Organotypical Airway Models
A Knorr, Q Dutertre, M Rhouma, E Martin, M Almstetter, S Majeed, C Mathis, S Frentzel, M Bentley, J Hoeng, P Vanscheeuwijck, M Peitsch
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Peer-Reviewed Publication
May 9, 2016
Platform 4
A Framework for In Vitro Systems Toxicology Assessment of e-Liquids
A Iskandar, I Gonzalez-Suarez, S Majeed, D Marescotti, A Sewer, Y Xiang, P Leroy, E Guedj, C Mathis, JP Schaller, P Vanscheeuwijck, S Frentzel, F Martin, NV Ivanov, M Peitsch, J Hoeng
Toxicology Mechanisms and Methods
DOI : 10.3109/15376516.2016.1170251
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Poster
May 2, 2016
Platform 1
Lung Inflammation and Toxicological Assessment in A/J Mice in Response to Chronic Exposure to Mainstream Aerosol from Candidate Modified Risk Tobacco Product and Smoke from Conventional Cigarettes
E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, E Veljkovic, AW Hayes, P Leroy, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
May 1, 2016
Heated Tobacco Products
Systems toxicological evaluation of a heat-not-burn tobacco product in a 90-day OECD inhalation study in comparison to cigarette smoke
U Kogel, Y Xiang, E T Wong, S Boue, F Martin, E Guedj, AW Hayes, M Peitsch, P Vanscheeuwijck, J Hoeng
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Presentation
May 1, 2016
Heated Tobacco Products
Toxicological Characterization of the Mentholated Heat-not-Burn Product THS2.2M in a 90-Day OECD Inhalation Study
A Oviedo, S Lebrun, G Rodrigo, J Ho, G Vuillaume, P Vanscheeuwijck, AW Hayes, J Hoeng, M Peitsch
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Poster
January 12, 2016
Nicotine-Containing E-Vapor Products
In Vitro Test Systems for Aerosols Toxicology Assessment - Characterization of Exposure, Metabolism and Kinetics
A Knorr, Q Dutertre, S Majeed, C Mathis, S Frentzel, M Bentley, J Hoeng, P Vanscheeuwijck
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Peer-Reviewed Publication
January 5, 2016
Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice.
S Ansari, K Baumer, S Boue, S Dijon, R Dulize, K Ekroos*, A Elamin, C Foong, E Guedj, J Hoeng, NV Ivanov, AS Krishnan *, P Leroy, F Martin, C Merg, M Peck, M Peitsch, B Phillips, W Schlage, T Schneider, M Talikka, B Titz, P Vanscheeuwijck, E Veljkovic, T Vihervaara*, G Vuillaume, CQ Woon
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 11, 2015
Platform 1
Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/− mice – a systems toxicology analysis
G Lo Sasso, B Titz, C Nury, S Boue, B Phillips, V Belcastro, T Schneider, S Dijon, K Baumer, D Peric, R Dulize, A Elamin, E Guedj, A Buettner*, P Leroy, S Kleinhans, G Vuillaume, E Veljkovic, NV Ivanov, F Martin, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.3109/08958378.2016.1150368
