About Stephanie
My role is to manage scientific transparency and verification aspects in the biomedical research department. My responsibilites involve the development of INTERVALS, a platform to share data, methods, and results. I am also the project leader of the Systems Biology Verification project.
Latest Publications
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Peer-Reviewed Publication
September 12, 2020
Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case
W Schlage, B Titz, A Iskandar, C Poussin, M Van der Toorn, E T Wong, P Pratte, S Maeder, JP Schaller, P Pospisil, S Boue, G Vuillaume, P Leroy, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2020.09.004
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Peer-Reviewed Publication
August 11, 2020
Heated Tobacco Products
Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol from a Heated Tobacco Product Compared with Cigarette Smoke
E T Wong, K Luettich, S Krishnan, S K Wong, WT Lim, D Yeo, A Buettner*, P Leroy, G Vuillaume, S Boue, J Hoeng, P Vanscheeuwijck, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfaa131
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Peer-Reviewed Publication
January 21, 2020
Platform 1
State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-not-burn tobacco products
S Boue, D Goedertier, J Hoeng, A Kuczaj, S Majeed, C Mathis, A May*, B Phillips, M Peitsch, F Radtke, W Schlage, W Teck Tan, P Vanscheeuwijck
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177/2397847319897869
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Peer-Reviewed Publication
December 21, 2019
Applying Systems Toxicology Methods to Drug Safety
M Talikka, V Belcastro, S Boue, D Marescotti, J Hoeng, M Peitsch
DOI : 10.1016/B978-0-12-801238-3.11522-3
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Peer-Reviewed Publication
March 18, 2019
Platform 1
Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2019.03.007
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Poster
December 3, 2018
Platform 1
Toxicological evaluation of the Tobacco Heating System 2.2, a candidate modified risk tobacco product in a OECD inhalation study complemented with systems toxicology
U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, P Vanscheeuwijck, J Hoeng, M Peitsch
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Peer-Reviewed Publication
October 3, 2018
Embracing Transparency Through Data Sharing
S Boue, M Byrne*, AW Hayes, J Hoeng, M Peitsch
* This author is not affiliated with PMI.International Journal of Toxicology
DOI : 10.1177/1091581818803880
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Poster
July 9, 2018
Crowdsourced-benchmarking of computational pipelines for metagenomic taxonomy profiling – the sbv IMPROVER Microbiomics Challenge
C Poussin, N Sierro, V Belcastro, JND Battey, S Boue, F Meyer*, E Scotti, A Petrelis, M Peitsch, NV Ivanov, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 13, 2017
Exploring the microbiome in health and disease: Implications for toxicology
E Scotti, S Boue, G Lo Sasso, F Zanetti, V Belcastro, C Poussin, N Sierro, JND Battey, A Gimalac, NV Ivanov, J Hoeng
Toxicology Research and Application
DOI : 10.1177/2397847317741884
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Poster
September 19, 2017
Platform 1
Systems Biology Verification Project: Past, Present, and Future.
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Peer-Reviewed Publication
September 5, 2017
Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure.
S Boue, T Exner*, D Ghosh, V Belcastro, J Dokler*, D Page, A Boda, F Bonjour, B Hardy*, P Vanscheeuwijck, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Presentation
July 27, 2017
Harness the Power of the Crowd to Address Computational and Biological Challenges
V Belcastro, S Boue
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Peer-Reviewed Publication
July 14, 2017
Platform 1
The sbv IMPROVER Systems Toxicology computational challenge: Identification of human and species-independent blood response markers as predictors of smoking exposure and cessation status
V Belcastro, C Poussin, Y Xiang, M Giordano*, KP Tripathi*, A Boda, AT Balci*, I Bilgen*, SD Dhanda*, Z Duan*, X Gong*, R Kumar*, R Romero*, OS Sarac*, AL Tarca*, P Wang*, H Yang*, W Yang*, S Boue, C Zhang*, MR Guarracino*, F Martin, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.comtox.2017.07.004
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Peer-Reviewed Publication
January 16, 2017
Platform 1
Crowd-sourced verification of computational methods and data in systems toxicology: a case study with a heat-not-burn candidate modified risk tobacco product
C Poussin, V Belcastro, F Martin, S Boue, M Peitsch, J Hoeng
Chemical Research in Toxicology
DOI : 10.1021/acs.chemrestox.6b00345
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Peer-Reviewed Publication
October 26, 2016
Platform 1
Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke
E T Wong, U Kogel, E Veljkovic, F Martin, Y Xiang, S Boue, G Vuillaume, P Leroy, E Guedj, G Rodrigo, NV Ivanov, J Hoeng, M Peitsch, P Vanscheeuwijck
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.10.015
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Publication
September 20, 2016
Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease
B Titz, K Luettich, P Leroy, S Boue, G Vuillaume, K Ekroos*, T Vihervaara*, F Martin, M Peitsch, J Hoeng
* This author is not affiliated with PMI.International Journal of Molecular Sciences
DOI : 10.3390/ijms17091583
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Peer-Reviewed Publication
July 20, 2016
Platform 2
Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications
AA Namasivayam*, AF Morales*, AM Lacave*, A Tallam*, B Simovic*, DG Alfaro*, DR Bobbili*, F Martin, G Androsova*, I Shvydchenko*, J Park*, JV Calvo*, J Hoeng, M Peitsch, MG Racero*, M Biryukov*, M Talikka, MB Perez*, N Rohatgi*, N Diaz*, R Mandarapu*, C D Ruiz*, S Davidyan*, S Narayanasamy*, S Boue, S Guryanova*, SM Arbas*, S Menon*, Y Xiang
* This author is not affiliated with PMI.Libertas Academica, Freedom to Research
DOI : 10.4137/GRSB.S39076
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Peer-Reviewed Publication
July 11, 2016
Crowdsourcing and Curation: Perspectives from Biology and Natural Language Processing
L Hirschman*, K Fort*, S Boue, N Kyrpides*, RI Doğan*, KB Cohen*
* This author is not affiliated with PMI.Database: The Journal of Biological Databases and Curation
DOI : 10.1093/database/baw115
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Poster
July 1, 2016
Platform 1
Systems toxicology analysis of cardiovascular and respiratory endpoints from ApoE-/- mice showed similar effects when switching to a candidate Modified Risk Tobacco Product, THS2.2, or ceasing smoking
B Phillips, E Guedj, A Elamin, S Boue, G Vuillaume, F Martin, P Leroy, N Sierro, AW Hayes, E Veljkovic, NV Ivanov, M Peitsch, J Hoeng
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Poster
June 9, 2016
Platform 1
Effects of Cigarette Smoke, Cessation and Switching to Aerosol from Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in Two Mouse Strains
T Schneider, B Titz, S Boue, B Phillips, M Talikka, T Vihervaara*, C Nury, A Elamin, E Guedj, M Peck, W Schlage, M Cabanski, P Leroy, G Vuillaume, F Martin, NV Ivanov, E Veljkovic, K Ekroos*, R Laaksonen, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
May 20, 2016
Platform 1
The Apoe(-/-) Mouse Model: A Suitable Model to Study Cardiovascular and Respiratory Diseases in the context of Cigarette Smoke Exposure and Harm Reduction
G Lo Sasso, W Schlage, S Boue, E Veljkovic, M Peitsch, J Hoeng
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Poster
May 1, 2016
Heated Tobacco Products
Systems toxicology analysis of cardiovascular and respiratory endpoints from Apoe-/- mice showed similar effects when switching to a candidate modified risk tobacco product, THS2.2 or ceasing smoking
B Phillips, E Guedj, A Elamin, S Boue, G Vuillaume, F Martin, P Leroy, AW Hayes, E Veljkovic, M Peitsch, J Hoeng
DOI : 10.4172/2376-0419-C1-021
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Poster
May 1, 2016
Heated Tobacco Products
Systems toxicological evaluation of a heat-not-burn tobacco product in a 90-day OECD inhalation study in comparison to cigarette smoke
U Kogel, Y Xiang, E T Wong, S Boue, F Martin, E Guedj, AW Hayes, M Peitsch, P Vanscheeuwijck, J Hoeng
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Poster
January 9, 2016
Platform 1
Long term exposure to cigarette smoke impacts genes involved in cardiac muscle structure and function in Apoe-/- mouse while exposure to a candidate modified risk tobacco product, the Tobacco Heating System 2.2 (THS 2.2) aerosol does not
J Szostak, S Boue, M Talikka, E Guedj, F Martin, B Phillips, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
January 5, 2016
Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice.
S Ansari, K Baumer, S Boue, S Dijon, R Dulize, K Ekroos*, A Elamin, C Foong, E Guedj, J Hoeng, NV Ivanov, AS Krishnan *, P Leroy, F Martin, C Merg, M Peck, M Peitsch, B Phillips, W Schlage, T Schneider, M Talikka, B Titz, P Vanscheeuwijck, E Veljkovic, T Vihervaara*, G Vuillaume, CQ Woon
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
December 11, 2015
Platform 1
Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/− mice – a systems toxicology analysis
G Lo Sasso, B Titz, C Nury, S Boue, B Phillips, V Belcastro, T Schneider, S Dijon, K Baumer, D Peric, R Dulize, A Elamin, E Guedj, A Buettner*, P Leroy, S Kleinhans, G Vuillaume, E Veljkovic, NV Ivanov, F Martin, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.3109/08958378.2016.1150368
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Peer-Reviewed Publication
November 25, 2015
Platform 1
An 8-month systems toxicology inhalation/cessation study in Apoe-/- mice to investigate cardiovascular and respiratory exposure effects of a candidate modified risk tobacco product, THS 2.2, compared with conventional cigarettes
B Phillips, E Veljkovic, S Boue, W Schlage, G Vuillaume, F Martin, B Titz, P Leroy, A Buettner*, A Elamin, A Oviedo, M Cabanski, E Guedj, T Schneider, M Talikka, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfv243
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Peer-Reviewed Publication
November 17, 2015
Effects of cigarette smoke, cessation and switching to two heat-not-burn tobacco products on lung lipid metabolism in C57BL/6 and Apoe-/- mice – an integrative systems toxicology analysis
B Titz, S Boue, B Phillips, M Talikka, T Vihervaara*, T Schneider, C Nury, A Elamin, E Guedj, M Peck, W Schlage, M Cabanski, P Leroy, G Vuillaume, F Martin, NV Ivanov, E Veljkovic, K Ekroos*, R Laaksonen, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfv244
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Poster
November 10, 2015
Heated Tobacco Products
Systems toxicology analysis of cardiovascular and respiratory endpoints from Apoe-/- mice showed similar effects after switching to a candidate modified risk tobacco product, THS 2.2, or to smoking cessation
B Phillips, E Veljkovic, S Boue, W Schlage, G Vuillaume, F Martin, B Titz, P Leroy, A Buettner*, A Elamin, M Cabanski, E Guedj, M Talikka, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
November 10, 2015
Toxicological evaluation of the Tobacco Heating System 2.2, a candidate Modified Risk Tobacco Product in a 90-Day OECD inhalation study complemented with systems toxicology
U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, G Rodrigo, E Veljkovic, J Hoeng, P Vanscheeuwijck, M Peitsch
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Peer-Reviewed Publication
August 21, 2015
Nicotine-Containing E-Vapor Products
Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology
B Phillips, M Esposito, J Verbeeck, S Boue, A Iskandar, G Vuillaume, P Leroy, AS Krishnan *, U Kogel, A Utan, W Schlage, E Veljkovic, M Bera, J Hoeng, M Peitsch, P Vanscheeuwijck
* This author is not affiliated with PMI.DOI : 10.3109/08958378.2015.1046000
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Peer-Reviewed Publication
May 20, 2015
Enhancement of COPD biological networks using a web-based collaboration interface
S Boue, B Fields*, J Hoeng, J Park*, M Peitsch, W Schlage, M Talikka
* This author is not affiliated with PMI.DOI : 10.12688/f1000research.5984.2
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Peer-Reviewed Publication
May 12, 2015
Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains
M Cabanski, B Fields*, S Boue, N Boukharov*, H De Leon, N Dror*, M Geertz, E Guedj, A Iskandar, U Kogel, C Merg, M Peck, C Poussin, W Schlage, M Talikka, NV Ivanov, J Hoeng, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1007/s00011-015-0820-2
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Peer-Reviewed Publication
April 22, 2015
Platform 2
A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product
B Phillips, E Veljkovic, M Peck, A Buettner*, A Elamin, E Guedj, G Vuillaume, NV Ivanov, F Martin, S Boue, W Schlage, T Schneider, B Titz, M Talikka, P Vanscheeuwijck, J Hoeng, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2015.03.009
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Poster
March 23, 2015
Platform 1
Systems toxicology analysis of cardiovascular and respiratory endpoints from Apoe-/- mice showed similar effects after switching to a candidate modified risk tobacco product, THS 2.2, or to smoking cessation-
B Phillips, S Boue, G Vuillaume, F Martin, P Leroy, E Veljkovic, M Peitsch, J Hoeng