Toxicological Assessment

      We obtain data on the potential of our smoke-free products to reduce the risk of smoking

      After a product has been developed and has been shown to generate lower levels of HPHCs in the aerosol compared to levels found in cigarette smoke, it undergoes Toxicological Assessment.

       

      You can find a summary of our entire product assessment program in the PMI Science Booklet.

      Toxicological Assessment tells us about how much damage to the biology of an organism the aerosol from a smoke-free product may cause compared to cigarette smoke, and if that damage is likely to activate biological mechanisms that may result in the onset of tobacco-related diseases.

      It is important to note that toxicological data on its own is not sufficient to prove that switching to smoke-free products is of reduced risk compared to continued cigarettes smoking; specially designed clinical studies are required to answer such questions. That being said, toxicological assessment provides a very good indication of the risk reduction and the confidence to move forward with clinical studies. Results from toxicological studies can also complement the data from clinical studies.

      Toxicity assessment helps to predict whether a given smoke-free product is likely to present less risk of harm compared to continued smoking.

      Toxicological Assessment

      Regulatory Toxicology

      Regulatory Toxicology focuses on assessing the toxicity of our products on cells grown in the laboratory and in laboratory animals. The main purpose of Regulatory Toxicology is to provide data for regulatory agencies on whether our products meet their defined acceptability criteria. These criteria include requirements for manufacturing and are prerequisites to clinical tests. In the case of smoke-free tobacco products, the aim is to demonstrate that the toxicity of the aerosol from smoke-free products is lower than that of cigarette smoke.

      Regulatory Toxicology assessment is performed under Good Laboratory Practice (GLP). GLP ensures uniformity, consistency, reliability, reproducibility, quality and integrity in the methodology of the tests and therefore the results.

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      Toxicological Assessment

      Systems Toxicology

      PMI is at the forefront of using systems biology and applying it to toxicology. Not only do we make full use of the most advanced biological and computational techniques available today, we are also leading the development of new methods that may become the new standards of tomorrow. Furthermore, we have a very comprehensive verification program in which we share the algorithms we develop and the data generated. Using expert crowdsourcing, we make our full data sets available for scrutiny and interpretation, and actively compare the findings to our own.

      Toxicological Assessment

      Advancing methods in toxicology

      Learn about methods in toxicology
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      Our findings

      PMIScience.com est exploité par Philip Morris International dans le but de publier et de diffuser des informations scientifiques concernant les démarches de Philip Morris International pour développer et évaluer des produits susceptibles de réduire les risques individuels et les dommages associés au tabagisme sur la population. Ce site est destiné aux scientifiques, aux acteurs de la santé publique et de la réglementation, ainsi qu’aux autres parties prenantes intéressées par la politique en matière de tabac. Ce site n’est pas exploité à des fins publicitaires ou de marketing. Il n’est pas destiné à être utilisé par les consommateurs.

      Le terme « produits à risque réduit » (RRP) désigne des produits qui présentent, sont susceptibles de présenter, ou ont le potentiel de présenter moins de risques pour les fumeurs qui adoptent ces produits par rapport à la consommation régulière de cigarettes. PMI dispose d’une gamme de RRP à différents stades de développement, d’évaluation scientifique et de commercialisation. Nos RRP sont des produits sans fumée qui produisent un aérosol contenant des quantités beaucoup plus faibles de composés nocifs et potentiellement nocifs que ceux émis par la fumée de cigarette.