Inflammation And Morphometric Changes In The Lungs Of Spontaneously Hypertensive Rats Following Cigarette Smoke Exposure Posters posters Systems Toxicologysystemstoxicology Jun 18, 2006 20060618 /content/dam/pmiscience/default-fallback-thumbnails/publication/fallback5.png
      Posters

      Inflammation And Morphometric Changes In The Lungs Of Spontaneously Hypertensive Rats Following Cigarette Smoke Exposure

      Vanscheeuwijck, P.; Meurrens, K.; Van Miert, E.; Friedrichs, B.; Weiler, H.
      Conference date
      Jun 18, 2006
      Conference name
      Society of Toxicologic Pathology 25th Annual Symposium
      Link to more information
      Link to more information
      Topic
      Summary

      Exposure to cigarette mainstream smoke (MS) induces lung inflammation, a key factor in the development of emphysema. Previously we have reported that acute and subchronic inhalation exposure of rats to diluted MS induces changes in inflammatory mediators and greater numbers of neutrophils in bronchoalveolar lavage fluid (BALF) (Vanscheeuwijck et al., 2004; Vanscheeuwijck et al., 2005; Friedrichs et al., in press). Here we report on inflammation and morphometric changes in the lungs of spontaneously hypertensive rats (SHR) following subchronic exposure to MS. The SHR strain is known to be susceptible to cigarette smoke and particle-induced cardiopulmonary alterations (Gilmour et al., 2004) and has been shown to have increased concentrations of MIP-2 and increased numbers of inflammatory cells in BALF following cigarette smoke exposure (Smith et al., 2002). We investigated pulmonary inflammation (cytokines, chemokines, and free lung cells in BALF) and morphometric changes in the lungs. 

      PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris International’s efforts to develop and assess products that have the potential to reduce individual risk and population harm associated with tobacco use. This site is for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not for advertising or marketing. It is not intended for use by consumers.

      Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. Our RRPs are smoke-free products that produce an aerosol that contains far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.