Independent studies

      A list of publications with original data and original analysis on our smoke-free products

      At PMI Science, we welcome and encourage independent research on our smoke-free products and our methods and results. Over the past few years, a growing number of organizations and institutions have initiated studies around our smoke-free products and/or the methods/results surrounding them.

      Updated: 16 March 2022

      Below we've listed those independent scientific studies with original data and original analysis we are aware of on our products and the wider product category. Publications without original data or analysis, such as many review articles, commentaries, and opinion pieces are not included. For the sake of transparency, we included all independent studies even if at times, we disagree with the methodology followed and/or the conclusions reached.

      Number of publications to-date: 279.

      Asterisk (*) indicates a non-product specific study.

      279. Rao, P et al. Comparable Impairment of Vascular Endothelial Function by a Wide Range of Electronic Nicotine Delivery DevicesNicotine & Tobacco Research. January 2022. 

      278. Lyu, Q et al. Diluted aqueous extract of heat-not-burn tobacco product smoke causes less oxidative damage in fibroblasts than conventional cigarette. Journal of Clinical Biochemistry and Nutrition. January 2022. 

      277. Koyama, S et alE-Cigarettes Use Behaviors in Japan: An Online Survey. International Journal of Environmental Research and Public Health. January 2022.*

      276. Gallus, S et al. Use of electronic cigarettes and heated tobacco products during the Covid-19 pandemicScientific Reports. January 2022.*

      275. Cruz-Jimenez, L et alHeated tobacco product use, its correlates, and reasons for use among Mexican smokers. Drug and Alcohol Dependence. January 2022.

      274. Menshov, V A et alInfluence of Nicotine from Diverse Delivery Tools on the Autonomic Nervous and Hormonal SystemsBiomedicines. January 2022.

      273. Tattan-Birch, H et alHeated tobacco products for smoking cessation and reducing smoking prevalenceCochrane Database of Systematic Reviews. January 2022. 

      272. Esposito, F et alAcrylamide levels in smoke from conventional cigarettes and heated tobacco products and exposure assessment in habitual smokersEnvironmental Research. January 2022.*

      271. Zhang, H et alAcid-Catalyzed Isomerization of Carbonyls-2,4- dinitrophenylhydrazone in Mainstream Smoke of Heat-Not-Burn Tobacco Product for HPLC AnalysisLGC North America.  January 2022. 

      234. Wang, L et al. Characterization of Respiratory Symptoms Among Youth Using Heated Tobacco Products in Hong Kong. JAMA Network Open. July 2021.

      233. Lee, J et alUse of heated tobacco products where their use is prohibitedTobacco Control. July 2021.

      232. Laverty, A A et alPrevalence and reasons for use of Heated Tobacco Products (HTP) in Europe: an analysis of Eurobarometer data in 28 countriesThe Lancet Regional Health Europe. July 2021.

      231. Pintado, A S et alAwareness and Use of Heat-Not-Burn Tobacco among Students of Egas Moniz—Cooperative of Higher EducationMedical Sciences Forum. July 2021. *

      230. Yang, Y et alImpact of flavours, device, nicotine levels and price on adult e-cigarette users’ tobacco and nicotine product choicesTobacco Control. July 2021.

      229. Horinouchi, T; Miwa, S. Comparison of cytotoxicity of cigarette smoke extract derived from heat-not-burn and combustion cigarettes in human vascular endothelial cellsJournal of Pharmacological Sciences. July 2021.

      228. Caruso, M et alScreening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettesRegulatory Toxicology and Pharmacology. July 2021.

      227. Han, M A. Ability to Purchase Tobacco Products and Smoking Behavior of Cigarettes, E-cigarettes, and Heated Tobacco Products in Korean AdolescentsAmerican Journal of Health Behavior. July 2021. *

      226. Brown, C et alAlternative Tobacco Product Use and Smoking Quit Attempts Among Teenagers in the United States: A Cross-Sectional StudyCureus. July 2021. *

      225. Ikonomidis, I et alDifferential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular functional. Scientific Reports. June 2021.

      224. Zhou, H et alRelease behaviors of main aerosol components from electrically heated cigarettes at different temperatures based on a bespoke test platformTobacco Science & Technology. June 2021. (In Chinese).

      223. Wang, L et al. Temperature distribution in tobacco section of an electrically heated cigarette and puff-by-puff releases of key smoke components: Part 2 SimulationTobacco Science & Technology. June 2021. (In Chinese)

      222. Sibul, F et alIdentification of biomarkers specific to five different nicotine product user groups: Study protocol of a controlled clinical trialContemporary Clinical Trials Communications. June 2021.

      221. Sawa, M et alA Newly Developed Aerosol Exposure Apparatus for Heated Tobacco Products for In Vivo Experiments Can Deliver Both Particles and Gas Phase With High Recovery and Depicts the Time-Dependent Variation in Nicotine Metabolites in Mouse UrineNicotine & Tobacco Research. June 2021.

      220. Hwang, J; Cho, S I. A comparative study on changes in the use of heat-not-burn tobacco products based on whether apartment buildings have designated non-smoking areasTobacco Prevention & Cessation. June 2021.

      219. Cho, Y H et alPilot Study on the Determination of Volatile Organic Compounds (VOCs) in Exhaled Breath of Each Cigarette TypeJournal of the Korean Society for Research on Nicotine and Tobacco. June 2021.

      218. Kwon, M et alUse of Single, Dual, and Poly Tobacco Products in Korean AdolescentsAsia Pacific Journal of Public Health. June 2021. *

      217. Tattan-Birch, H et alTrends in use of e-cigarette device types and heated tobacco products from 2016 to 2020 in EnglandScientific Reports. June 2021.

      216. Li, S et alAdolescent Use of and Susceptibility to Heated Tobacco ProductsPediatrics. June 2021.

      215. Popova, T M et alThe Vascular Endothelium Function Indicators in Oral Liquid of IQOS Smoking Adolescents. Ukrainian Dental Almanac. June 2021.

      214. Azagba, S; Shan, L. Disparities in the frequency of tobacco products use by sexual identity status. Addictive Behaviors. June 2021. *

      213. Zhao, G et al. Differences in aroma component releases in aerosols of self-made electrically heated cigarette with different tobacco materialsTobacco Science & Technology. May 2021. (In Chinese). *

      212. Li, X et alResearch progress on risk assessment framework for novel tobacco products and recommendation for China. Tobacco Science & Technology. May 2021. (In Chinese). *

      211. Chen, J et alThe applicability of different tobacco types to heated tobacco productsIndustrial Crops and Products. May 2021. *

      210. Camacho, O N et alModeling the Population Health Impacts of Heated Tobacco Products in JapanTobacco Regulatory Science. May 2021. *

      209. Denlinger-Apte, R L et alRisk Perceptions of Low Nicotine Cigarettes and Alternative Nicotine Products across Priority Smoking PopulationsInternational Journal of Environment Research and Public Health. May 2021.

      208. Zobena, A. Student Tobacco Use Behaviors: A Qualitative Study of Alternative Tobacco and Nicotine Product Use in Young AdulthoodRural Environment. Education. Personality. May 2021. 

      207. Kim, J et alHeated tobacco product use and its relationship to quitting combustible cigarettes in Korean adultsPLoS One. May 2021.

      206. Phillips-Waller, A et alNicotine delivery and user ratings of IQOS heated tobacco system compared to cigarettes, Juul and refillable e-cigarettesNicotine & Tobacco Research. May 2021.

      205. Yaman, B et alComparison of IQOS (heated tobacco) and cigarette smoking on cardiac functions by two-dimensional speckle tracking echocardiography. Toxicology and Applied Pharmacology. May 2021.

      204. Heide, J et alPuff-resolved analysis and selected quantification of chemicals in the gas phase of E-Cigarettes, Heat-not-Burn devices and conventional cigarettes using single photon ionization time-of-flight mass spectrometry (SPI-TOFMS): A comparative studyNicotine & Tobacco Research. May 2021.

      203. Lee, A et alThe Utilization of National Tobacco Cessation Services among Female Smokers and the Need for a Gender-Responsive ApproachInternational Journal of Environmental Research and Public Health. May 2021. *

      202. Pagano, S et alHeat-not-burn tobacco (IQOS), oral fibroblasts and keratinocytes: cytotoxicity, morphological analysis, apoptosis and cellular cycle. An in vitro study. Journal of Periodontal Research. May 2021.

      201. Rosen, L et alProtecting Children From Tobacco Smoke Exposure: A Randomized Controlled Trial of Project Zero ExposureNicotine & Tobacco Research. May 2021.

      200. Vivarelli, F et alUnburned tobacco cigarette smoke alters rat ultrastructural lung airways and DNANicotine & Tobacco Research. May 2021.

      199. Chen-Sakey, J C et alEffect of a hypothetical modified risk tobacco product claim on heated tobacco product use intention and perceptions in young adultsTobacco Control. May 2021.

      198. Berg, C J et al. Heated tobacco product awareness, use, and perceptions in a sample of young adults in the United StatesNicotine & Tobacco Research. April 2021.

      197. East, K A et alTrends and Patterns of Tobacco and Nicotine Product Use Among Youth in Canada, England, and the United States From 2017 to 2019Journal of Adolescent Health. April 2021.

      196. Chavarrio Canas, J E et alEarly Chemistry of Nicotine Degradation in Heat-Not-Burn Smoking Devices and Conventional Cigarettes: Implications for Users and Second- and Third-Hand SmokersJournal of Physical Chemistry A. April 2021. *

      195. Zhao, D et alPerceptions of e-cigarettes among smokers and non-smokers in households with children in rural China: A cross-sectional studyTobacco Induced Diseases. April 2021.

      194. Gravely, S et alSelf-reported quit aids and assistance used by smokers at their most recent quit attempt: Findings from the 2020 International Tobacco Control Four Country Smoking and Vaping SurveyNicotine & Tobacco Research. April 2021.

      193. Ke, W et alStructural Characteristics and Properties of Polylactic Acid (PLA) and Cellulose Triacetate (CTA) Fibers for Heat-Not-Burn (HNB) CigarettesIOP Conference Series: Earth and Environmental Science. April 2021. *

      192. East, K A et al'I perceive it to be less harmful, I have no idea if it is or not:' a qualitative exploration of the harm perceptions of IQOS among adult usersHarm Reduction Journal. April 2021.

      191. AlMulla, A et alEpidemiology of tobacco use in Qatar: Prevalence and its associated factorsPLoS One. April 2021. *

      190. Jankowski, M et alThe prevalence of cigarette, e-cigarette and heated tobacco use among police employees in Poland: a 2020 cross-sectional surveyInternational Journal of Occupational Medicine and Environmental Health. April 2021.

      189. Loffredo, L et alImpact of chronic use of heat-not-burn cigarettes on oxidative stress, endothelial dysfunction and platelet activation: the SUR-VAPES Chronic StudyThorax. April 2021.

      188. Kanai, M et alAssociation of heated tobacco product use with tobacco use cessation in a Japanese workplace: a prospective studyThorax. April 2021. *

      187. Tong, Y et alEffects of Glycerol and Propylene Glycol on Smoke Release of Heat-not-burn Tobacco ProductsJournal of Physics: Conference Series. April 2021. *

      186. Monzon, J et alEffects of tobacco product type and characteristics on appeal and perceived harm: Results from a discrete choice experiment among Guatemalan adolescentsPreventive Medicine. April 2021.

      185. Krysinski, A et alInternational randomised controlled trial evaluating metabolic syndrome in type 2 diabetic cigarette smokers following switching to combustion-free nicotine delivery systems: the DIASMOKE protocolBMJ Open. April 2021. *

      184. Rudasingwa, G et alComparison of Nicotine Dependence and Biomarker Levels among Traditional Cigarette, Heat-Not-Burn Cigarette, and Liquid E-Cigarette Users: Results from the Think StudyInternational Journal of Environmental Research and Public Health. April 2021.

      183. Wang, L et alTemperature distribution in tobacco section of an electrically heated cigarette and puff-by-puff variation of key smoke components: Part 1. ExperimentsTobacco Science & Technology. March 2021. (In Chinese).

      182. Luo, W et alPreparation and design of "cool and low retention" filter rods for heated tobacco productsTobacco Science & Technology. March 2021. (In Chinese).

      181. Jones, J D et alCross-sectional Survey to Assess Tobacco and Nicotine Product Use since the Introduction of Tobacco Heating Products in Japan: Wave 1Tobacco Regulatory Science. March 2021.

      180. Li, L et alPatterns of non-cigarette tobacco and nicotine use among current cigarette smokers and recent quitters: Findings from the 2020 ITC Four Country Smoking and Vaping Survey. Nicotine & Tobacco Research. March 2021. *

      179. Kawasaki, Y et alUrinary biomarkers for secondhand smoke and heated tobacco products exposureJournal of Clinical Biochemistry and Nutrition. March 2021. *

      178. Yang, B et alEffects of modified risk tobacco product claims on consumer comprehension and risk perceptions of IQOSTobacco Control. March 2021.

      177. Odani, S; Tabuchi, T. Prevalence of heated tobacco product use in Japan: the 2020 JASTIS studyTobacco Control. March 2021.

      176. Lau, Y K et alNicotine dependence of cigarette and heated tobacco users in Japan, 2019: a cross-sectional analysis of the JASTIS StudyTobacco Control. March 2021.

      175. Koyama, S et alChanges in Smoking Behavior Since the Declaration of the COVID-19 State of Emergency in Japan: A Cross-sectional Study From the Osaka Health AppJournal of Epidemiology. March 2021.

      174. Polosa, R et alHealth outcomes in COPD smokers using heated tobacco products: a 3-year follow-upInternal and Emergency Medicine. March 2021.

      173. Majek, P et alThe Frequency of Use and Harm Perception of Heated Tobacco Products (HTPs): The 2019 Cross-Sectional Survey among Medical Students from PolandInternational Journal of Environmental Research and Public Health. March 2021.

      172. Yoshioka, T; Tabuchi, T. Combustible cigarettes, heated tobacco products, combined product use, and periodontal disease: A cross JASTIS studyPLOS one. March 2021.

      171. Zhu, S-H et alEarly adoption of heated tobacco products resembles that of e-cigarettesTobacco Control. February 2021.

      170. Park, J et alPerceptions of heated tobacco products (HTPs) and intention to quit among adult tobacco users in KoreaJournal of Epidemiology. February 2021.

      169. Imura, Y; Tabuchi, T. Exposure to Secondhand Heated-Tobacco-Product Aerosol May Cause Similar Incidence of Asthma Attack and Chest Pain to Secondhand Cigarette Exposure: The JASTIS 2019 StudyInternational  Journal of Environmental Research and Public Health. February 2021. *

      168. Wang, Y et alEffects of conventional and heated tobacco product smoking on discoloration of artificial denture teethThe Journal of Prosthetic Dentistry. February 2021.

      167. Gallus, S et alThe Role of Novel (Tobacco) Products on Tobacco Control in Italy. International Journal of Environmental Research and Public Health. February 2021.

      166. Yi, J et alPrevalence and predictors of heated tobacco products use among male ever smokers: results from a Korean longitudinal study. BMC Public Health. February 2021. *

      165. Gallus, S et al. Use and Awareness of Heated Tobacco Products in EuropeJournal of Epidemiology. January 2021.

      164. Huh, Y; Cho, H J. Associations between the Type of Tobacco Products and Suicidal Behaviors: A Nationwide Population-Based Study among Korean AdolescentsInternational Journal of Environmental Research and Public Health. January 2021.

      163. Matsuyama, Y; Tabuchi, T. Heated tobacco product use and combustible cigarette smoking relapse/initiation among former/never smokers in Japan: the JASTIS 2019 study with 1-year follow-up. Tobacco Control. January 2021.

      162. Luo, C et al. Effects of potassium additives on the combustion characteristics of graphite as a heating source of heat-not-burn tobaccoRSC Advances. January 2021. *

      161. Brett, E I et alEffects of Visual Exposure to IQOS Use on Smoking Urge and BehaviorTobacco Regulatory Science. January 2021.

      160. Pokhrel, P et alHeat-not-burn Tobacco Products and the Increased Risk for Poly-tobacco Use. American Journal of Health Behavior. January 2021.

      159. Lee, J et alHeated tobacco product use among US adolescents in 2019: The new tobacco risk. Tobacco Prevention & Cessation. January 2021.

      158. Akiyama, Y; Sherwood, N. Systematic review of biomarker findings from clinical studies of electronic cigarettes and heated tobacco productsToxicology Reports. January 2021.

      157. Azagba, S; Shan, L. Heated Tobacco Products: Awareness and Ever Use Among U.S. AdultsAmerican Journal of Preventive Medicine. January 2021.


      156. Queloz, S; Etter J-F. A survey of users of the IQOS tobacco vaporizer: perceived dependence and perceived effects on cigarette withdrawal symptomsJournal of Addictive Diseases. December 2020.

      155. Gottschlich, A et alCross-sectional study on the awareness, susceptibility and use of heated tobacco products among adolescents in Guatemala City, Guatemala. BMJ Open. December 2020. 

      154. Bhat, T A et al. Acute effects of heated tobacco product (IQOS) aerosol inhalation on lung tissue damage and inflammatory changes in the lungsNicotine & Tobacco Research. December 2020.

      153. Chang, L C et al. Prevalence of heated tobacco product use among adolescents in TaiwanPLOS ONE. December 2020.

      152. Li, Y et al. Modeled Respiratory Tract Deposition of Smoke Aerosol from Conventional Cigarettes, Electronic Cigarettes and Heat-not-burn ProductsAerosol and Air Quality Research. December 2020.

      151. Marukina, H I et alVerrucous leukoplakia of the red border; caused by the use of IQOS heated tobacco product (a case report)Zaporozhye Medical Journal. December 2020.

      150. Kiyohara, K; Tabuchi T. Use of heated tobacco products in smoke-free locations in Japan: the JASTIS 2019 study. Tobacco Control. November 2020.

      149. Ito, Y et al. Heat-Not-Burn cigarette induces oxidative stress response in primary rat alveolar epithelial cells. PLOS ONE. November 2020.

      148. Hirano, T et al. Exposure Assessment of Environmental Tobacco Aerosol from Heated Tobacco Products: Nicotine and PM Exposures under Two Limited ConditionsInternational Journal of Environmental Research and Public Health. November 2020.

      147. Hirano, T; Takei, T. Estimating the Carcinogenic Potency of Second-Hand Smoke and Aerosol from Cigarettes and Heated Tobacco ProductsInternational Journal of Environmental Research and Public Health. November 2020.

      146. Yoshida, S et al. Effects of Fetal Exposure to Heat-Not-Burn Tobacco on Testicular Function in Male OffspringBiological and Pharmaceutical Bulletin. November 2020.

      145. Simms, L et al. The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettesCurrent Research in Toxicology. November 2020.

      144. Xu, S S et al. Reasons for Regularly Using Heated Tobacco Products among Adult Current and Former Smokers in Japan: Finding from 2018 ITC Japan Survey. International Journal of Environmental Research and Public Health. October 2020.

      143. Scharf, P et al. Immunotoxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor on Jurkat T cell functionsEnvironmental Pollution. October 2020.

      142. Murkett, R et al. Nicotine products relative risk assessment: a systematic review and meta-analysis. F1000Research. October 2020. *

      141. Yumoto, T et al. Potentially fatal ingestion of heat-not-burn cigarettes successfully treated by gastric lavageJournal of the American College of Emergency Physicians Open. October 2020.

      140. Hwang, J H et al. Cigarette or E-Cigarette Use as Strong Risk Factors for Heated Tobacco Product Use among Korean Adolescents. International Journal of Environmental Research and Public Health. September 2020.

      139. Miller, C R et al. Awareness, trial and use of heated tobacco products among adult cigarette smokers and e-cigarette users: findings from the 2018 ITC Four Country Smoking and Vaping SurveyTobacco Control. September 2020.

      138. Moldoveanu, S C et al. Variations of TSNA levels in tobaccos upon heating at moderate temperaturesBeiträge zur Tabakforschung International/Contributions to Tobacco Research. September 2020. *

      137. Sutanto, E et al. Perceived relative harm of heated tobacco products (IQOS), e-cigarettes, and cigarettes among adults in Canada: Findings from the ITC Project. Tobacco Induced Diseases. September 2020.

      136. Lee, C M. The Impact of Heated Tobacco Products on Smoking Cessation, Tobacco Use, and Tobacco Sales in South KoreaKorean Journal of Family Medicine. September 2020. *

      135. Gruszczynski, L; Melillo, M. The FCTC dilemma on heated tobacco products. Globalization and Health. September 2020.

      134. Luk T T et alAssociation of heated tobacco product use with smoking cessation in Chinese cigarette smokers in Hong Kong: a prospective studyTobacco Control. September 2020.

      133. Jiang, X et al. Effects of puffing parameters on mainstream aerosol emissions from electrically heated tobacco productsChina Tobacco Journal. 2020. (In Chinese).

      132. Sun, Z et al. Electro-thermal simulation of heating element for electrically heated tobacco productsTobacco Science & Technology. September 2020. (In Chinese)  *

      131. Kim, S H; Cho H-J (2020). Prevalence and correlates of current use of heated tobacco products among a nationally representative sample of Korean adults: Results from a cross-sectional study. Tobacco Induced Diseases. August 2020.

      130. Cho, J H. Association between Heated Tobacco Products Use and Suicidal Behaviors among AdolescentsJournal of Environmental Health Sciences. August 2020. (In Korean).

      129. Papaefsthathiou, E et al. Breath analysis of smokers, non-smokers, and e-cigarette users. Journal of Chromatography B. August 2020.

      128. Aspera-Werz R H et al. Assessment of tobacco heating system 2.4 on osteogenic differentiation of mesenchymal stem cells and primary human osteoblasts compared to conventional cigarettesWorld Journal of Stem Cells. August 2020.

      127. Peruzzi, M et al. Comparative Indoor Pollution from Glo, Iqos, and Juul, Using Traditional Combustion Cigarettes as Benchmark: Evidence from the Randomized SUR-VAPES AIR TrialInternational Journal of Environmental Research and Public Health. August 2020.

      126. Kim S H et al. Beliefs about the harmfulness of heated tobacco products compared with combustible cigarettes and their effectiveness for smoking cessation among Korean adultsInternational Journal of Environmental Research and Public Health. August 2020. *

      125. Topuridze, M et al. Smokers' and Nonsmokers' Receptivity to Smoke-Free Policies and Pro- and Anti-Policy Messaging in Armenia and GeorgiaInternational Journal of Environmental Research and Public Health. July 2020.

      124. Franzen, K F et al. The impact of heated tobacco products on arterial stiffnessVascular Medicine. July 2020.

      123. El-Hage, R et al. Vaped Humectants in E-Cigarettes Are a Source of Phenols. Chemical Research in Toxicology. July 2020.

      121. Cammalleri, V et alHow Do Combustion and Non-Combustion Products Used Outdoors Affect Outdoor and Indoor Particulate Matter Levels? A Field Evaluation Near the Entrance of an Italian University LibraryInternational Journal of Environmental Research and Public Health. July 2020.

      120. Lee, T et al. Mitigation of harmful chemical formation from pyrolysis of tobacco waste using CO2Journal of Hazardous Materials. July 2020.

      119. Dusautoir, G et al. Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cellsJournal of Hazardous Materials. July 2020.

      118. Tong, Y et al. Study on the influence factors of the release characteristics of IQOS cigarette smokeIOP Conference Series: Earth and Environmental Science. July 2020.

      117. Arslan, H N et al. Evaluation of the Opinions of Family Physicians on Some Tobacco Products. Journal of Community Health. July 2020.

      116. Liu H et al. MD-GC/MS analysis of aerosol components of heated tobacco products (HTPs). China Tobacco Journal. June 2020. (In Chinese).

      115. Deng J et al Overview of the battery management system (BMS) of heated tobacco products (HTPs) smoking setsChina Tobacco Journal. June 2020. (In Chinese).

      114. Lempert, L K; Glantz, S. Analysis of FDA's IQOS marketing authorisation and its policy impactsTobacco Control. June 2020.

      113. Lee, Y-C et al. Comparing the Characteristics of Cigarette Smoking and e-Cigarette and IQOS Use among Adolescents in TaiwanJournal of Environmental and Public Health. June 2020.

      112. Li Nga, J D et alComparison of End Tidal Carbon Monoxide Levels Between Conventional Cigarette, Electronic Cigarette and Heated Tobacco Product Among Asiatic SmokersSubstance Use & Misuse. June 2020.

      111. Wang, L et alHarmful Chemicals of Heat Not Burn Product and Its Induced Oxidative Stress of Macrophages at Air-Liquid Interface: Comparison With Ultra-Light Cigarette Toxicology Letters. June 2020.

      110. Hori, A et alRapid Increase in Heated Tobacco Product (HTP) Use From 2015 to 2019: From the Japan 'Society and New Tobacco' Internet Survey (JASTIS)Tobacco Control. June 2020.

      109. Biondi Zoccai, G et al. A randomized trial comparing the acute coronary, systemic, and environmental effects of electronic vaping cigarettes versus heat-not-burn cigarettes in smokers of combustible cigarettes undergoing invasive coronary assessment: rationale and design of the SUR-VAPES 3 trialMinerva Cardioangiologica. June 2020.

      108. Pataka, A et al. Acute Effects of a Heat-Not-Burn Tobacco Product on Pulmonary FunctionMedicina. June 2020.

      107. Ilies, B D et al. Identification of volatile constituents released from IQOS heat-not-burn tobacco HeatSticks using a direct sampling method. Tobacco Control. May 2020.

      106. Adamson, J et al. Results from a 2018 cross-sectional survey in Tokyo, Osaka and Sendai to assess tobacco and nicotine product usage after the introduction of heated tobacco products (HTPs) in Japan. Harm Reduction Journal. May 2020.

      105. Bitzer, Z T et al. Free Radical Production and Characterization of Heat-Not-Burn Cigarettes in Comparison to Conventional and Electronic Cigarettes. Chemical Research in Toxicology. May 2020.

      104. Savdie, J et alPassive Exposure to Pollutants from a New Generation of Cigarettes in Real Life ScenariosInternational Journal of Environmental Research and Public Health. May 2020.

      103. Kim, K et al. Gendered factors for heated tobacco product use: Focus group interviews with Korean adultsTobacco Induced Diseases. May 2020.

      102. Slob, W et al. A Method for Comparing the Impact on Carcinogenicity of Tobacco Products: A Case Study on Heated Tobacco Versus CigarettesRisk Analysis. May 2020.

      101. Kuwabara, Y et al. Comparing Factors Related to Any Conventional Cigarette Smokers, Exclusive New Alternative Product Users, and Non-Users among Japanese Youth: A Nationwide Survey. International Journal of Environmental Research and Public Health. April 2020.

      100. Ioakeimidis, N et alAcute effect of heat-not-burn versus standard cigarette smoking on arterial stiffness and wave reflections in young smokersEuropean Journal of Preventive Cardiology. April 2020.

      99. Protano, C et al. Impact of Electronic Alternatives to Tobacco Cigarettes on Indoor Air Particular Matter Levels. International Journal of Environmental Research and Public Health. April 2020.

      98. Calabuig, E; Marcilla, A. The effect of the addition of SBA-15 to the slow pyrolysis of tobacco studied by heart-cutting GC/MCJournal of Thermal Analysis and Calorimetry. April 2020. *

      97. Thompson, M E et al. Survey Methods of the 2018 International Tobacco Control (ITC) Japan SurveyInternational Journal of Environmental Research and Public Health. April 2020.

      96. Igarashi, A et al. Heated Tobacco Products Have Reached Younger or More Affluent People in Japan. Journal of Epidemiology. March 2020.

      95. Cruz-Jiménez, L et alAdult Smokers’ Awareness and Interest in Trying Heated Tobacco Products: Perspectives from Mexico, where HTPs and E-Cigarettes are BannedInternational Journal of Environmental Research and Public Health. March 2020.

      94. Kim, Y H; An, Y J. Development of a standardized new cigarette smoke generating (SNCSG) system for the assessment of chemicals in the smoke of new cigarette types (heat-not-burn (HNB) tobacco and electronic cigarettes (E-Cigs)). Environmental Research. March 2020.

      93. Siripongvutikorn, Y et alWorkplace smoke-free policies that allow heated tobacco products and electronic cigarettes use are associated with use of both these products and conventional tobacco smoking: the 2018 JASTIS studyTobacco Control. March 2020.

      92. Phan, L et al. Young Adult Correlates of IQOS Curiosity, Interest, and Likelihood of UseTobacco Regulatory Science. March 2020.

      91. Sutanto, E et alConcurrent Daily and Non-Daily Use of Heated Tobacco Products with Combustible Cigarettes: Findings from the 2018 ITC Japan SurveyInternational Journal of Environmental Research and Public Health. March 2020.

      90. Sugiyama, T; Tabuchi T. Use of Multiple Tobacco and Tobacco-Like Products Including Heated Tobacco and E-Cigarettes in Japan: A Cross-Sectional Assessment of the 2017 JASTIS Study. International Journal of Environmental Research and Public Health. March 2020.

      89. Obertova, N et al. Acute exposures to e-cigarettes and heat-not-burn products reported to the Czech Toxicological Information Centre over a 7-year period (2012-2018). Basic & Clinical Pharmacology & Toxicology. February 2020. *

      88. Maloney, S et alAcute effects of JUUL and IQOS in cigarette smokersTobacco Control. February 2020. 

      87. Zagoriti, Z et al. Effects of Exposure to Tobacco Cigarette, Electronic Cigarette and Heated Tobacco Product on Adipocyte Survival and Differentiation In VitroToxics. February 2020.

      86. Kang, S Y et al. Prevalence and predictors of heated tobacco product use and its relationship with attempts to quit cigarette smoking among Korean adolescentsTobacco Control. February 2020.

      85. Liu, X et al. Electronic cigarettes in Italy: a tool for harm reduction or a gateway to smoking tobacco?Tobacco Control. February 2020.

      84. Lee, C M. International regulatory overview of electronic cigarettes and heated tobacco productsJournal of Korean Medical Association. February 2020. (In Korean).

      83. Dunbar, M S et al. Correlates of Awareness and Use of Heated Tobacco Products in a Sample of US Young Adults in 2018-2019. Nicotine & Tobacco Research. February 2020.

      82. Frati, G et al. Profiling the Acute Effects of Modified Risk Products: Evidence from the SUR-VAPES (Sapienza University of Rome-Vascular Assessment of Proatherosclerotic Effects of Smoking) Cluster StudyCurrent Atherosclerosis Reports. February 2020.

      81. Sansone, G et al. Secondhand Smoke Exposure in Public Places and Support for Smoke-Free Laws in Japan: Findings from the 2018 ITC Japan Survey. International Journal of Environmental Research and Public Health. February 2020. *

      80. Chung-Hall, J et al. Effectiveness of text-only cigarette health warnings in Japan: Findings from the 2018 International Tobacco Control (ITC) Japan surveyInternational Journal of Environmental Research and Public Health. February 2020. *

      79. Tompkins, C N E et al. Factors that influence smokers’ and ex-smokers’ use of IQOS: a qualitative study of IQOS users and ex-users in the UKTobacco Control. January 2020.

      78. Jones, J et alA cross-category puffing topography, mouth level exposure and consumption study among Italian users of tobacco and nicotine productsScientific Reports. January 2020.

      77. Caponnetto, P et al. Non-inferiority trial comparing cigarette consumption, adoption rates, acceptability, tolerability, and tobacco harm reduction potential in smokers switching to Heated Tobacco Products or electronic cigarettes: Study protocol for a randomized controlled trialContemporary Clinical Trials Communications. January 2020.

      76. Jun, J. Social Response to the FDA Authorization of Heated Tobacco Products (HTPs). Tobacco Regulatory Science. January 2020.

      75. Koutela, N et al. A comprehensive study on the leaching of metals from heated tobacco sticks and cigarettes in water and natural watersScience of The Total Environment. January 2020.

      74. Richter, D J. Cardiologists and smoking alternatives: what we should knowEuropean Society of Cardiology. December 2019.

      73. Kwon, E et alExperience and Current Use of Heated Tobacco Products in Korean Military PersonnelKorean Journal of Health Promotion. December 2019. (In Korean).

      72. Sutanto, E et al. Prevalence, Use Behaviors, and Preferences among Users of Heated Tobacco Products: Findings from the 2018 ITC Japan SurveyInternational Journal of Environmental Research and Public Health. November 2019.

      71. Kinjo, A et alHeated tobacco product smokers in Japan identified by a population-based survey. Journal of Epidemiology. November 2019.

      70. Baran, W et alThe influence of waste from electronic cigarettes, conventional cigarettes and heat-not-burn tobacco products on microorganismsJournal of Hazardous Materials. November 2019.

      69. Loupa, G et al. The trace of airborne particulate matter from smoking e-cigarette, tobacco heating system, conventional and hand-rolled cigarettes in a residential environmentAir Quality, Atmosphere & Health. October 2019.

      68. Ikonomidis, I et alP450 Effects of IQOS smoking on vascular function , coronary flow reserve, myocardial deformation and myocardial work index during one month of useEuropean Heart Journal. October 2019.

      67. Beatrice, F et al. Exhaled carbon monoxide levels in forty resistant to cessation male smokers after six months of full switch to electronic cigarettes (e-cigs) or to a tobacco heating system (THS)International Journal of Environmental Research and Public Health. October 2019.

      66. Davis, B et alComparison of cytotoxicity of IQOS aerosols to smoke from Marlboro Red and 3R4F reference cigarettesToxicology in Vitro. September 2019.

      65. Tobari, H et alTobacco cessation training in 6-year pharmacy schools in Japan: a cross-sectional surveyBMJ Open. July 2019.

      64. Malela, S et al. Effects of IQOS on macrophage viability and functionERJ Open Research. June 2019.

      63. Nistorescu, N et al. Difficulties in measuring the amount of cyanide by various methods and their application in the toxicological risk assessment of classic cigarettes versus IQOS systemActa Medica Marisiensis. June 2019.

      62. Kang, H; Cho, S-i. Heated tobacco product use among Korean adolescentsTobacco Control. June 2019.

      61. Lee J G L et alEvolving IQOS packaging designs change perceptions of product appeal, uniqueness, quality and safety: a randomised experiment, 2018, USATobacco Control. June 2019.

      60. Farsalinos, K et alPatterns of use, past smoking status, and biochemically verified current smoking status of heated tobacco product (IQOS) shops customers: preliminary resultsChest. June 2019.

      59. Stoklosa, M et al. Effect of IQOS introduction on cigarette sales: evidence of decline and replacementTobacco Control. June 2019.

      58. Cancelada, L et alHeated Tobacco Products: Volatile Emissions and Their Predicted Impact on Indoor Air QualityEnvironmental Science & Technology. May 2019.

      57. Meehan-Atrash, J et alFree-Base Nicotine Is Nearly Absent in Aerosol from IQOS Heat-Not-Burn Devices, As Determined by 1H NMR SpectroscopyChemical Research in Toxicology. May 2019.

      56. Hair, E C et al. Examining perceptions about IQOS heated tobacco product: consumer studies in Japan and SwitzerlandTobacco Control. May 2019.

      55. Queloz, S; Etter, JF. An online survey of users of tobacco vaporizers, reasons and modes of utilization, perceived advantages and perceived risksBMC Public Health. May 2019.

      54. Ishizaki, A; Kataoka, H. A sensitive method for the determination of tobacco-specific nitrosamines in mainstream and sidestream smokes of combustion cigarettes and heated tobacco products by online in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometryAnalytica Chimica Acta. May 2019.

      53. Biondi-Zoccai, G et al. Acute Effects of Heat‐Not‐Burn, Electronic Vaping, and Traditional Tobacco Combustion Cigarettes: The Sapienza University of Rome‐Vascular Assessment of Proatherosclerotic Effects of Smoking (SUR‐VAPES) 2 Randomized TrialJournal of the American Heart Association. March 2019.

      52. Davis, B et al. iQOS: evidence of pyrolysis and release of a toxicant from plasticTobacco Control. March 2019. [Our response].

      51. Aspera-Werz, R. et al. Comparative analysis of tobacco heating system and combustion of conventional cigarettes on osteogenic differentiation of mesenchymal stem cells and human osteoblasts.  Abstracts of the 85th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 21th Annual Meeting of the Association of the Clinical Pharmacology Germany (VKliPha). February 2019.

      50. Gong, S et al. Puff-by-puff release of main aerosol components from two commercial heat-not-burn tobacco productsTobacco Chemistry. February 2019.

      49. Sohal, S S et al. IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigaretteERJ Open Research. February 2019.

      48. Schober, W et al. Passive exposure to pollutants from conventional cigarettes and new electronic smoking devices (IQOS, e-cigarette) in passenger carsInternational Journal of Hygiene and Environmental Health. January 2019.

      47. Liu, X et al. Heat-not-burn tobacco products: concerns from the Italian experienceTobacco Control. January 2019.

      46. Czoli, C D et al. Awareness and interest in IQOS heated tobacco products among youth in Canada, England and the USATobacco Control. January 2019.

      45. Tabuchi, T et al. Heat-not-burn tobacco product use in Japan: its prevalence, predictors and perceived symptoms from exposure to secondhand heat-not-burn tobacco aerosolTobacco Control. December 2018.

      44. Adriaens, K et alIQOSTM vs. e-Cigarette vs. Tobacco Cigarette: A Direct Comparison of Short-Term Effects after Overnight-AbstinenceInternational Journal of Environmental Research and Public Health. December 2018.

      43. Salman, R et alFree-Base and Total Nicotine, Reactive Oxygen Species, and Carbonyl Emissions From IQOS, a Heated Tobacco ProductNicotine & Tobacco Research. November 2018.

      42. Lachenmeier, DW et al. Heat-Not-Burn Tobacco Products: The Devil in Disguise or a Considerable Risk Reduction? International Journal of Alcohol and Drug Research. October 2018.

      41. Tabuchi, T et al. Study Profile: The Japan “Society and New Tobacco” Internet Survey (JASTIS): A Longitudinal Internet Cohort Study of Heat-Not-Burn Tobacco Products, Electronic Cigarettes, and Conventional Tobacco Products in Japan. Journal of Epidemiology. October 2018.

      40. Liber, A C. Heated tobacco products and combusted cigarettes: comparing global prices and taxesTobacco Control. October 2018.

      39. Pacitto, A et alCharacterization of airborne particles emitted by an electrically heated tobacco smoking systemEnvironmental Pollution. September 2018.

      38. Leigh, N J et alCytotoxic effects of heated tobacco products (HTP) on human bronchial epithelial cellsTobacco Control. September 2018. [Our response].

      37. Leigh, N J et al. Tobacco-specific nitrosamines (TSNA) in heated tobacco product IQOSTobacco Control. September 2018.

      36. Nabavizadeh, P et al. Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smokeTobacco Control. September 2018. [Our response].

      35. Hitosugi, M et alCriminal mercury vapor poisoning using heated tobacco productInternational Journal of Legal Medicine. September 2018.

      34. Kioi, Y; Tabuchi, T. Electronic, heat-not-burn, and combustible cigarette use among chronic disease patients in Japan: A cross-sectional studyTobacco Induced Diseases. September 2018.

      33. Gasparyan, H et al. Accurate measurement of main aerosol constituents from heated tobacco products (HTPs): Implications for a fundamentally different aerosolRegulatory Toxicology and Pharmacology. September 2018.

      32. El-Toukhy, S et al. Impact of modified risk tobacco product claims on beliefs of US adults and adolescentsTobacco Control. August 2018.

      31. Nyman, A L et al. Awareness and use of heated tobacco products among US adults, 2016–2017Tobacco Control. August 2018.

      30. Kim, J et al. Awareness, experience and prevalence of heated tobacco product, IQOS, among young Korean adultsTobacco Control. August 2018.

      29. Caponnetto, P et alCarbon monoxide levels after inhalation from new generation heated tobacco productsRespiratory Research. August 2018.

      28. Si, X et al. Aerosol particle size distribution from an electrical heat-not-burn product under ISO and HCI smoking regimesTobacco Chemistry. August 2018.

      27. Gale, N et al. Changes in Biomarkers of Exposure on Switching From a Conventional Cigarette to Tobacco Heating Products: A Randomized, Controlled Study in Healthy Japanese Subjects. Nicotine & Tobacco Research. June 2018.

      26. Uchiyama, S et al. Simple Determination of Gaseous and Particulate Compounds Generated from Heated Tobacco Products. Chemical Research in Toxicology. June 2018.

      25. Farsalinos, K E et alNicotine Delivery to the Aerosol of a Heat-Not-Burn Tobacco Product: Comparison With a Tobacco Cigarette and E-Cigarettes. Nicotine & Tobacco Research. June 2018.

      24. Farsalinos, K E et al. Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e‐cigarette and a tobacco cigarette. Addiction. June 2018.

      23. Mallock, N et al. Levels of selected analytes in the emissions of “heat not burn” tobacco products that are relevant to assess human health risksArchives of Toxicology. May 2018.

      22. Brose, L S et alAwareness and Use of 'Heat-not-burn' Tobacco Products in Great BritainTobacco Regulatory Science. March 2018.

      21. Miyashita, L; Grigg, J. Effect of the iQOS electronic cigarette device on susceptibility to S. pneumoniae infectionJournal of Allergy and Clinical Immunology. February 2018.

      20. Haswell, L E et al. In vitro RNA-seq-based toxicogenomics assessment shows reduced biological effect of tobacco heating products when compared to cigarette smokeScientific Reports. February 2018.

      19. Kawamura, K et alHealth Effects Accompanying the Transition from Cigarettes to Heat-not-burn Tobacco: Nicotine Dependence, Nicotine Withdrawal Symptoms, and Changes in Smoking Behaviors. Nihon Eiseigaku Zasshi. January 2018.

      18. Miyazaki, Y; Tabuchi, T. Educational gradients in the use of electronic cigarettes and heat-not-burn tobacco products in JapanPLOS One. January 2018.

      17. Li, X et alChemical Analysis and Simulated Pyrolysis of Tobacco Heating System 2.2 Compared to Conventional CigarettesNicotine & Tobacco Research. January 2018.

      16. Murphy, J et alAssessment of tobacco heating product THP1.0. Part 9: The placement of a range of next-generation products on an emissions continuum relative to cigarettes via pre-clinical assessment studiesRegulatory Toxicology and Pharmacology. October 2017.

      15. Thorne, D et alAssessment of novel tobacco heating product THP1.0. Part 7: Comparative in vitro toxicological evaluationRegulatory Toxicology and Pharmacology. October 2017.

      14. Taylor, M et alAssessment of novel tobacco heating product THP1.0. Part 6: A comparative in vitro study using contemporary screening approachesRegulatory Toxicology and Pharmacology. October 2017.

      13. Jaunky, T et alAssessment of tobacco heating product THP1.0. Part 5: In vitro dosimetric and cytotoxic assessmentRegulatory Toxicology and Pharmacology. October 2017.

      12. Forster, M et alAssessment of novel tobacco heating product THP1.0. Part 3: Comprehensive chemical characterisation of harmful and potentially harmful aerosol emissionsRegulatory Toxicology and Pharmacology. October 2017.

      11. Bekki, K et alComparison of Chemicals in Mainstream Smoke in Heat-not-burn Tobacco and Combustion CigarettesJournal of UOEH. September 2017.

      10. Gale, N et alA randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating productBMC Public Health. August 2017.

      9. Gee, J et alAssessment of tobacco heating product THP1.0. Part 8: Study to determine puffing topography, mouth level exposure and consumption among Japanese usersRegulatory Toxicology and Pharmacology. August 2017.

      8. Protano, C et alSecond-hand smoke generated by combustion and electronic smoking devices used in real scenarios: Ultrafine particle pollution and age-related dose assessmentEnvironment International. July 2017.

      7. Kvasha, E A et alEvaluation of the impact of electronic nicotine delivery systems on the risk of cardiovascular diseases based on endothelial function and its determining July 2017.

      6. Auer, R et alHeat-Not-Burn Tobacco Cigarettes: Smoke by Any Other NameJAMA Internal Medicine. May 2017. [Our response].

      5. Ruprecht, A A et alEnvironmental pollution and emission factors of electronic cigarettes, heat-not-burn tobacco products, and conventional cigarettesAerosol Science and Technology. March 2017.

      4. Veronese, C et alCigarette smoke, e-cig vapor and “heat-not-burn”: a comparison between the emissions of toxic compoundTabaccologia. January 2017.

      3. Protano, C et alSecond-hand smoke exposure generated by new electronic devices (IQOS® and e-cigs) and traditional cigarettes: submicron particle behaviour in human respiratory systemAnneli Di Igiene. March 2016.

      2. Tabuchi, T et alAwareness and use of electronic cigarettes and heat‐not‐burn tobacco products in Japan. Addiction. November 2015.

      1. O'Connell, G et alHeated Tobacco Products Create Side-Stream Emissions: Implications for RegulationJournal of Environmental Analytical Chemistry. October 2015.