About Julia
My role is to manage Systems Toxicology at PMI Research & Development where I lead the Systems Biology Program, covering a portfolio of projects from in vitro, in vivo and in silico research for product testing. I have established a team with systems biology excellence at PMI Research & Development over the last seven years and I am also the project leader of the Systems Biology Verification project
Latest Publications
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Peer-Reviewed Publication
February 18, 2020
Alternatives to Animal Use in Risk Assessment of Mixtures
AW Hayes, A Muriana*, A Alzualde*, DB Fernandez*, A Iskandar, M Peitsch, A Kuczaj, J Hoeng
* This author is not affiliated with PMI.International Journal of Toxicology
DOI : 10.1177/1091581820905088
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Peer-Reviewed Publication
February 13, 2020
Anthropometry-based generation of personalized and population-specific human airway models
R Kannan*, ZJ Chen*, A Przekwas*, P Segars*, F Martin, A Kuczaj, J Hoeng
* This author is not affiliated with PMI.International Journal for Numerical Methods in Biomedical Engineering
DOI : 10.1002/cnm.3324
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Peer-Reviewed Publication
January 24, 2020
Nicotine-Containing E-Vapor Products
A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke
J Szostak, E T Wong, B Titz, T Lee, S K Wong, T Low, KM Lee*, J Zhang*, A Kumar*, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, Y Xiang, F Martin, A Sewer, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.American Journal of Physiology - Heart and Circulatory Physiology
DOI : 10.1152/ajpheart.00613.2019
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Peer-Reviewed Publication
January 23, 2020
In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures
D Marescotti, D Bovard, M Morelli, A Sandoz, K Luettich, S Frentzel, M Peitsch, J Hoeng
SLAS TECHNOLOGY: Translating Life Sciences Innovation
DOI : 10.1177/2472630319895473
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Peer-Reviewed Publication
January 21, 2020
Platform 1
State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-not-burn tobacco products
S Boue, D Goedertier, J Hoeng, A Kuczaj, S Majeed, C Mathis, A May*, B Phillips, M Peitsch, F Radtke, W Schlage, W Teck Tan, P Vanscheeuwijck
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177/2397847319897869
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Peer-Reviewed Publication
January 7, 2020
Assessment of Single-Photon Ionization Mass Spectrometry for Online Monitoring of in Vitro Aerosol Exposure Experiments
C Frege, M Asgari, S Steiner, S Ferreira, S Majeed, F Lucci, S Frentzel, J Hoeng, A Kuczaj
Chemical Research in Toxicology
DOI : doi.org/10.1021/acs.chemrestox.9b00381
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Peer-Reviewed Publication
January 6, 2020
Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond
Critical Reviews in Toxicology
DOI : 10.1080/10408444.2019.1692780
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Peer-Reviewed Publication
December 21, 2019
Applying Systems Toxicology Methods to Drug Safety
M Talikka, V Belcastro, S Boue, D Marescotti, J Hoeng, M Peitsch
DOI : 10.1016/B978-0-12-801238-3.11522-3
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Peer-Reviewed Publication
December 19, 2019
An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors
O Alijevic, D McHugh, L Rufener*, A Mazurov, J Hoeng, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1016/j.phytochem.2019.112187
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Peer-Reviewed Publication
November 25, 2019
Nicotine-Containing E-Vapor Products
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2019.11.016
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Peer-Reviewed Publication
November 22, 2019
Experimental and computational investigation of a nose-only exposure chamber
F Lucci, W Teck Tan, S Krishnan, J Hoeng, P Vanscheeuwijck, R Jaeger*, A Kuczaj
* This author is not affiliated with PMI.Aerosol Science and Technology
DOI : 10.1080/02786826.2019.1687843
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Peer-Reviewed Publication
November 15, 2019
Neurobehavioral effects of selected tobacco constituents in rodents following subchronic administration
European Journal of Pharmacology
DOI : 10.1016/j.ejphar.2019.172809
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Peer-Reviewed Publication
November 13, 2019
Heated Tobacco Products
Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products
M Van der Toorn, K Koshibu, W Schlage, S Majeed, P Pospisil, J Hoeng, M Peitsch
DOI : 10.1016/j.toxrep.2019.11.008
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Peer-Reviewed Publication
November 6, 2019
Heated Tobacco Products
Structural, functional, and molecular impact on the cardiovascular system in ApoE−/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke
J Szostak, B Titz, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, L Neau, K Trivedi, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Chemico-Biological Interactions
DOI : 10.1016/j.cbi.2019.108887
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Peer-Reviewed Publication
October 10, 2019
Deposition Efficiency and Uniformity of Monodisperse Solid Particle Deposition in the Vitrocell® 24/48 Air-Liquid-Interface in-vitro Exposure System
M J Oldham*, ND Castro*, J Zhang*, AA Rostami*, F Lucci, YB Pithawalla*, A Kuczaj, I G Gilman*, P Kosachevsky*, J Hoeng, K M Lee*
* This author is not affiliated with PMI.Aerosol Science and Technology
DOI : 10.1080/02786826.2019.1676877
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Peer-Reviewed Publication
September 9, 2019
Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles
DOI : 10.1080/08958378.2019.1662526
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Peer-Reviewed Publication
September 7, 2019
Nicotine-Containing E-Vapor Products
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology
A Iskandar, F Zanetti, D Marescotti, B Titz, A Sewer, A Kondylis, P Leroy, V Belcastro, L Ortega Torres, S Acali, S Majeed, S Steiner, K Trivedi, E Guedj, C Merg, T Schneider, S Frentzel, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1007/s00204-019-02565-9
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Peer-Reviewed Publication
September 3, 2019
NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks
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Poster
August 27, 2019
Evaluation of a small whole-body exposure chamber for mice
W Teck Tan, S Krishnan, B Phillips, A Kuczaj, J Hoeng, P Vanscheeuwijck
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Peer-Reviewed Publication
August 22, 2019
Heated Tobacco Products
3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow – application in systems toxicology
C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI.DOI : 10.14573/altex.1811301
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Peer-Reviewed Publication
August 17, 2019
Platform 4
Effects of different discoloration challenges and whitening treatments on dental hard tissues and composite resin restorations
X Zhao, F Zanetti, L Wang*, J Pan*, S Majeed, H Malmstrom*, M Peitsch, J Hoeng, Y Ren*
* This author is not affiliated with PMI.DOI : 10.1016/j.jdent.2019.103182
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Peer-Reviewed Publication
July 3, 2019
Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties
S Schorderet Weber, K P. Kaminski, JL Perret*, P Leroy, A Mazurov, M Peitsch, NV Ivanov, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.110660
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Infoposter
July 2, 2019
A lung-on-a-chip platform for improved tissue maturation
D Bovard, A Sandoz, M Morelli, A Iskandar, K Trivedi, K Luettich, S Frentzel, J Hoeng
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Publication
June 22, 2019
Systems toxicology approach to unravel early indicators of squamous cell carcinoma rate in rat nasal epithelium induced by formaldehyde exposure
International Conference on Practical Applications of Computational Biology & Bioinformatics
DOI : 10.1007/978-3-030-23873-5_3
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Publication
June 13, 2019
Mitochondria as a possible target for nicotine action
D Malińska*, M Wieckowski*, B Michalska*, K Drabik*, M Prill*, P Patalas-Krawczyk*, J Walczak*, J Szymanski*, C Mathis, M Van der Toorn, K Luettich, J Hoeng, M Peitsch, J Duszynski*, J Szczepanowska*
* This author is not affiliated with PMI.Journal of Bioenergetics and Biomembranes
DOI : 10.1007/s10863-019-09800-z
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Publication
June 12, 2019
Impact of sample preparation upon intracellular metabolite measurements in 3D cell culture systems
C Mathon, D Bovard, Q Dutertre, S Sendyk, M Bentley, J Hoeng, A Knorr
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Publication
June 10, 2019
Development of a realistic human respiratory tract cast representing physiological thermal conditions
M Asgari, F Lucci, J Bialek, B Dunan*, G Andreatta*, R Smajda*, S Lani*, N Blondiaux*, S Majeed, S Steiner, JP Schaller, S Frentzel, J Hoeng, A Kuczaj
* This author is not affiliated with PMI.Aerosol Science and Technology
DOI : 10.1080/02786826.2019.1612839
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Poster
May 9, 2019
Characterization of the Vitrocell® Cloud SEQ 24 System and its Application in Exposure to Aerosolized Bortezomib and Ibuprofen
S Steiner, S Ferreira, M Morelli, A Baldi, A Kuczaj, S Frentzel, M Van der Toorn, M Peitsch, J Hoeng
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Poster
May 8, 2019
Aerosol evolution and deposition in the human upper respiratory tract
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Peer-Reviewed Publication
April 11, 2019
Systems toxicology meta-analysis – from aerosol exposure to nanotoxicology
M Talikka, V Belcastro, S Gubian, F Martin, M Peitsch, J Hoeng
DOI : 10.1016/j.cotox.2019.03.010
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Presentation
April 9, 2019
A method for determination of tracheobronchial airway geometries from four different strains of mice
J Hoeng, C Foong, F Lucci, D Yeo, J Chua, A Kuczaj, M Peitsch
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Presentation
March 27, 2019
Assessment of potential neuroprotective effects of alkaloids in a human dopaminergic in vitro model of Parkinson’s disease
MB Fares, C Mathis, A Kondylis, O Alijevic, N Sierro, J Hoeng, M Peitsch
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Publication
March 26, 2019
Heated Tobacco Products
A meta-analysis of the performance of a blood-based exposure response gene signature across clinical studies on the Tobacco Heating System 2.2 (THS 2.2)
F Martin, M Talikka, NV Ivanov, C Haziza, J Hoeng, M Peitsch
DOI : 10.3389/fphar.2019.00198
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Peer-Reviewed Publication
March 18, 2019
Nicotine-Containing E-Vapor Products
Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
KM Lee*, J Hoeng, S Harbo*, U Kogel, W Gardner*, M J Oldham*, E Benson*, M Talikka, A Kondylis, F Martin, B Titz, S Ansari, K Trivedi, E Guedj, A Elamin, NV Ivanov, P Vanscheeuwijck, M Peitsch, WJ McKinney*
* This author is not affiliated with PMI.DOI : 10.1080/08958378.2019.1576807
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Peer-Reviewed Publication
March 18, 2019
Platform 1
Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2019.03.007
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Peer-Reviewed Publication
March 18, 2019
GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology
V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1093/bioinformatics/btz187
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Presentation
March 16, 2019
Platform 1
Cardiovascular Effects of the Tobacco Heating System (THS) Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, C Poussin, P Vanscheeuwijck
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Poster
March 16, 2019
Physiologically based Pharmacokinetic Modeling of Nicotine from Inhaled Aqueous Aerosol Predicts Marked Gastrointestinal Absorption in Rats
AR Kolli, F Martin, Y Xiang, B Titz, E T Wong, W Schlage, E Veljkovic, P Vanscheeuwijck, J Hoeng
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Poster
March 12, 2019
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, K Baumer, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, K Luettich, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
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Publication
March 12, 2019
Human multi-organ-chip co-culture approach of bronchial airway and liver models for substance exposure studies
S Frentzel, K Schimek*, K Luettich, D Bovard, I Rütschle*, L Boden*, F Rambo*, A Winter*, U Marx*, J Hoeng
* This author is not affiliated with PMI. -
Poster
March 12, 2019
Heated Tobacco Products
Xenobiotic metabolism response to 3R4F or THS2.2 exposure: from pre-clinical to clinical
S Pouly, M Talikka, A van der Plas, B Titz, A Iskandar, G de La Bourdonnaye, N Blanc, F Martin, C Haziza, NV Ivanov, F Lüdicke, J Hoeng, M Peitsch
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Publication
March 12, 2019
Nicotine-Containing E-Vapor Products
Exposure to an aerosol from a novel electronic cigarette using the MESH™ technology elicited reduced biological impacts than exposure to cigarette smoke on buccal and small airway epithelial cultures: a systems toxicology assessment
A Iskandar, F Zanetti, A Kondylis, F Martin, A Sewer, L Ortega Torres, S Majeed, S Steiner, E Guedj, C Merg, T Schneider, K Trivedi, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
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Publication
March 12, 2019
A method for determination of tracheobronchial airway geometries from four different strains of mice
C Foong, M J Oldham*, F Lucci, S. Cockram*, S. Luke*, D Yeo, J Chua, J Hoeng, M Peitsch, A Kuczaj
* This author is not affiliated with PMI. -
Poster
March 12, 2019
GladiaTOX: global assessment of dose-response indicators in toxicology
V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng
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Publication
March 12, 2019
Nicotine-Containing E-Vapor Products
Comparison of the impacts of an acute exposure to electronic cigarette aerosol and cigarette smoke on small airway epithelial cultures: In vitro systems toxicology assessment
A Iskandar, A Kondylis, F Martin, S Steiner, S Majeed, P Leroy, E Guedj, C Merg, K Trivedi, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
March 5, 2019
Platform 4
A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment
A Iskandar, F Zanetti, A Kondylis, F Martin, P Leroy, S Majeed, S Steiner, Y Xiang, L Ortega Torres, K Trivedi, E Guedj, C Merg, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Internal and Emergency Medicine
DOI : 10.1007/s11739-019-02055-x
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Poster
February 28, 2019
Platform 1
Chronic Toxicity and Lung Carcinogenicity in A/J Mice Following Lifetime Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
K Luettich, E T Wong, K Trivedi, E Guedj, T Schneider, C Nury, B Titz, Y Xiang, P Leroy, G Vuillaume, P Vanscheeuwijck, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
February 27, 2019
Optimization of a Novel In Situ Hybridization Technology on 3D Organotypic Cell Cultures
L Neau, C Lorin, S Frentzel, J Hoeng, A Iskandar, P Leroy, K Trivedi
DOI : 10.1089/aivt.2018.0021