About Julia
My role is to manage Systems Toxicology at PMI Research & Development where I lead the Systems Biology Program, covering a portfolio of projects from in vitro, in vivo and in silico research for product testing. I have established a team with systems biology excellence at PMI Research & Development over the last seven years and I am also the project leader of the Systems Biology Verification project
Latest Publications
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Peer-Reviewed Publication
January 9, 2022
Translational Modeling of Chloroquine and Hydroxychloroquine Dosimetry in Human Airways for Treating Viral Respiratory Infections
AR Kolli, F Calvino, J Hoeng
DOI : 10.1007/s11095-021-03152-3
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Peer-Reviewed Publication
December 15, 2021
Iota-carrageenan extracted from red algae is a potent inhibitor of SARS-CoV-2 infection in reconstituted human airway epithelia
D Bovard, M Van der Toorn, W Schlage, S Constant*, K Renggli , M Peitsch, J Hoeng
* This author is not affiliated with PMI.Biochemistry and Biophysics Reports
DOI : 10.1016/j.bbrep.2021.101187
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Peer-Reviewed Publication
December 10, 2021
Platform 1
A Literature Review and Framework Proposal for Halitosis Assessment in Cigarette Smokers and Alternative Nicotine-Delivery Products Users
F Zanetti, T Zikovic Semren, JND Battey, P A. Guy*, NV Ivanov, A van der Plas, J Hoeng
* This author is not affiliated with PMI.DOI : 10.3389/froh.2021.777442
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Peer-Reviewed Publication
November 27, 2021
Platform 1
Impact of aerosols on liver xenobiotic metabolism: A comparison of two methods of exposure
D Bovard, K Renggli , D Marescotti, A Sandoz, S Majeed, L Pinard, S Ferreira, C Pak, A Barbier, A Beguin , A Iskandar, S Frentzel, J Hoeng, M Peitsch
DOI : 10.1016/j.tiv.2021.105277
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Peer-Reviewed Publication
September 24, 2021
Assessment of in vitro kinetics and biological impact of nebulized trehalose on human bronchial epithelium
A Iskandar, AR Kolli, A Giralt, L Neau, M. Fatarova, A Kondylis, L Ortega Torres, S Majeed, C Merg, M Corciulo, K Trivedi, E Guedj, S Frentzel, F Calvino, P A. Guy*, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2021.112577
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Peer-Reviewed Publication
September 15, 2021
A simple method for decellularizing a cell-derived matrix for bone cell cultivation and differentiation
W Weng*, F Zanetti, D Bovard, B Braun*, S Ehnert*, T Uynuk-Ool*, T Histing*, J Hoeng, AK Nussler*, RH Aspera-Werz*
* This author is not affiliated with PMI.Journal of Materials Science: Materials in Medicine
DOI : 10.1007/s10856-021-06601-y
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Poster
August 23, 2021
Generation of reporter gene models based on genetically engineered progenitor cells using crispr-cas9 technology
M Alriquet , D Bovard, R Dulize, D Bornand, JND Battey, E Guedj, N Sierro, C Pak, S Majeed, K Luettich, M Van der Toorn, S Frentzel, J Hoeng
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Publication
July 27, 2021
Platform 1
Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro
C Poussin, M Van der Toorn, S Scheuner, R Piault, A Kondylis, R Savioz*, R Dulize, D Peric, E Guedj, F Maranzano, C Merg, M Morelli, A L Egesipe, S Johne, S Majeed, C Pak, T Schneider, W Schlage, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1007/s00204-021-03123-y
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Peer-Reviewed Publication
July 15, 2021
Effects of nicotinic acetylcholine receptor‑activating alkaloids on anxiety‑like behavior in zebrafish
A Alzualde*, O Jaka*, D Latino, O Alijevic, I Iturria*, J H de Mendoza*, P Pospisil, S Frentzel, M Peitsch, J Hoeng, K Koshibu
* This author is not affiliated with PMI.DOI : 10.1007/s11418-021-01544-8
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Peer-Reviewed Publication
July 2, 2021
Platform 1
Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract
JND Battey, J Szostak, B Phillips, C Teng, CK Tung, WT Lim, YS Yeo, S Ouadi, K Baumer, J Thomas, J Martinis , N Sierro, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.3389/fmicb.2021.587745
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Peer-Reviewed Publication
June 28, 2021
Subchronic effects of plant alkaloids on anxiety-like behavior in zebrafish
A Hawkey*, J Hoeng, M Peitsch, E Levin*, K Koshibu
* This author is not affiliated with PMI.Pharmacology Biochemistry Behavior
DOI : 10.1016/j.pbb.2021.173223
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Peer-Reviewed Publication
June 15, 2021
Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish
R Li*, M Talikka, S Gubian, C. vom Berg*, F Martin, M Peitsch, J Hoeng, A. Zupanic*
* This author is not affiliated with PMI.DOI : 10.3389/fgene.2021.652632
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Peer-Reviewed Publication
June 3, 2021
Effects of plant alkaloids on mitochondrial bioenergetic parameters
P Patalas-Krawczyk*, D Malinska*, J Walczak*, G Kratzer, M Prill*, B Michalska*, K Drabik*, B Titz, Y Eb-Levadoux, T Schneider, J Szymanski*, J Hoeng, M Peitsch, J Duszynski*, J Szczepanowska*, M Van der Toorn, C Mathis, M Wieckowski*
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2021.112316
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Peer-Reviewed Publication
June 1, 2021
Systems biology approach highlights mechanistic differences between Crohn’s disease and ulcerative colitis
P A Ruiz Castro, H Yepiskoposyan, S Gubian, F Martin, U Kogel, K Renggli , M Peitsch, J Hoeng, M Talikka
DOI : 10.1038/s41598-021-91124-3
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Peer-Reviewed Publication
May 13, 2021
Effects of Natural Monoamine Oxidase Inhibitors on Anxiety-Like Behavior in Zebrafish
O Jaka*, I Iturria*, M Van der Toorn, J H de Mendoza*, D Latino, A Alzualde*, M Peitsch, J Hoeng, K Koshibu
* This author is not affiliated with PMI.DOI : 10.3389/fphar.2021.669370
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Peer-Reviewed Publication
May 12, 2021
Aerosol Filtration Testing of Fabrics for Development of Reusable Face Masks
A Stan, S Steiner, S Majeed, S Schorderet Weber, S Gosh*, T Zikovic Semren, P A. Guy*, S Lebrun, J Steinhauser*, Y Tardy*, A Hogg*, S Chiquet*, JL Perret*, A Kuczaj, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Aerosol and Air Quality Research (Special Issue for COVID-19)
DOI : 10.4209/aaqr.210052
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Peer-Reviewed Publication
May 10, 2021
Differential effects of alkaloids on memory in rodents
P Callahan *, A Terry *, M Peitsch, J Hoeng, K Koshibu
* This author is not affiliated with PMI.DOI : 10.1038/s41598-021-89245-w
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Peer-Reviewed Publication
May 7, 2021
Platform 4
A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract
E T Wong, J Szostak, B Titz, T Lee, S K Wong, O Lavrynenko, C Merg, M Corciulo, J Simicevic, M Auberson, D Peric, R Dulize, D Bornand, G Loh, KM Lee*, J Zhang*, J Miller IV, W Schlage, E Guedj, T Schneider, B Phillips, P Leroy, MA Choukrallah, N Sierro, A Buettner*, Y Xiang, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1007/s00204-021-03020-4
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Article
April 22, 2021
Platform 4
Effects of whitening toothpaste and bleaching treatment on resin composite discoloration caused by cigarette smoke and electronic vapor aerosol
X Zhao, F Zanetti, L Wang , H Malmstrom*, S Majeed, M Peitsch, J Hoeng, Y Ren*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
April 16, 2021
Development of an Advanced Multicellular Intestinal Model for Assessing Immunomodulatory Properties of Anti-Inflammatory Compounds
D Marescotti, G Lo Sasso, D Guerrera, K Renggli , P A Ruiz Castro, R Piault, V Jaquet, F Moine, K Luettich, S Frentzel, M Peitsch, J Hoeng
DOI : 10.3389/fphar.2021.639716
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Publication
March 15, 2021
Platform 4
A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysematous changes following smoking cessation or switching to e-vapor products
K Ashutosh*, U Kogel, M Talikka, C Merg, E Guedj, Y Xiang, A Kondylis, B Titz, NV Ivanov, J Hoeng, M Peitsch, J Allen*, A Gupta *, A Skowronek*, K M Lee*
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177%2F2397847321995875
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Peer-Reviewed Publication
March 11, 2021
Platform 1
In Vivo Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy
W Xia, AR Kolli, K Koshibu, F Martin, A Kondylis, A Kuczaj, W Teck Tan, YS Yeo, G Tan, C Teng, K Woon , T Schneider, M Talikka, B Phillips, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1021/acs.jnatprod.0c01044
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Research
February 3, 2021
Impact of whole-body versus nose-only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE -/- mouse model
U Kogel, E T Wong, J Szostak, W Teck Tan, P Leroy, F Lucci, B Titz, Y Xiang, T Low, S K Wong, E Guedj, NV Ivanov, W Schlage, M Peitsch, A Kuczaj, P Vanscheeuwijck, J Hoeng
DOI : 10.1002/jat.4149
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Book Chapter
January 18, 2021
Toxicological Evaluation of Electronic Nicotine Delivery Products
F Zanetti, W Xia, E T Wong, P Vanscheeuwijck, M Van der Toorn, B Titz, M Talikka, J Szostak, M Smith, D Smart, D Sciuscio, W Schlage, JP Schaller, R Savioz*, P Pratte, C Poussin, S Pouly, P Picavet, B Phillips, M Peck, M Mitova, D McHugh, A May*, C Mathis, F Martin, D Marescotti, S Maeder, K Luettich, F Lucci, A Kuczaj, AR Kolli, U Kogel, NV Ivanov, A Iskandar, C Haziza, C Goujon-Ginglinger, S Frentzel, M Firestone , MA Choukrallah, D Bovard, S Boue, M Bentley, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Publication
January 1, 2021
Platform 1
An interlaboratory in vitro aerosol exposure system reference study
D Thorne*, J Adamson*, E Trelles-Sticken, R Wieczorek*, HP Behrsing *, S Steiner, S Majeed, S Frentzel, S Ishikawa*, S Ito*, L Simms *, K Yoshino*, J Hoeng, M Gaca*
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177/2F2397847321992752
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Peer-Reviewed Publication
December 29, 2020
Platform 3
State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products
S Boue, D Goedertier, J Hoeng, A Iskandar, A Kuczaj, D Marescotti, C Mathis, A May*, B Phillips, M Peitsch, W Schlage, D Sciuscio, W Teck Tan, P Vanscheeuwijck
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177/2397847320979751
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Presentation
December 9, 2020
Platform 3
Comparative Assessment of Pharmacokinetics and Acute Lung Inflammation of Nicotine Dry Powder Aerosols Generated by PreciseInhale®
S Lam, R Ng, B Phillips, W Teck Tan, C Teng, C Wong, R Piault, C Merg, D Sciuscio, J Hoeng, P Vanscheeuwijck
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Peer-Reviewed Publication
November 18, 2020
Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures
A Giralt, A Iskandar, F Martin, E Moschini*, T Serchi*, A Kondylis, D Marescotti, P Leroy, L Ortega Torres, S Majeed, C Merg, K Trivedi, E Guedj, S Frentzel, NV Ivanov, M Peitsch, AC Gutleb*, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.toxlet.2020.11.006
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Peer-Reviewed Publication
November 12, 2020
Platform 1
Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies
O Lavrynenko, B Titz, S Dijon, D Dos Santos , C Nury, T Schneider, E Guedj, J Szostak, A Kondylis, B Phillips, K Ekroos*, F Martin, M Peitsch, J Hoeng, NV Ivanov
* This author is not affiliated with PMI.DOI : 10.1016/j.lfs.2020.118753
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Peer-Reviewed Publication
October 29, 2020
Heated Tobacco Products
Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity
A van der Plas, S Pouly, N Blanc, C Haziza, G de La Bourdonnaye, B Titz, J Hoeng, NV Ivanov, BV Taranu, A Heremans
DOI : 10.1016/j.toxrep.2020.10.017
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Poster
October 28, 2020
Development and testing of the Independent Holistic Air-Liquid Aerosol Exposure System (InHALES)
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Poster
October 19, 2020
Nicotine-Containing E-Vapor Products
Plasma Protein Biomarker Identification for Monitoring Molecular Changes in Smokers, Former Smokers, and E-Vapor Product Users Compared with Never Smokers
C Nury, Y Eb-Levadoux, AR Kolli, C Poussin, TM Curran*, LA Baglia*, RA Berg*, Loyse Felber Medlin , S Ansari, E Kishazi, F Martin, B Titz, P Picavet, NV Ivanov, SL Spinelli*, J Hoeng, M Peitsch
* This author is not affiliated with PMI. -
Poster
October 4, 2020
Heated Tobacco Products
Assessing the impact of switching to the Tobacco Heating System on cardiovascular diseases: Translating basic science into clinical benefit
G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Luedicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch, C Pater
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Poster
September 21, 2020
Lung/liver-on-a-chip for systemic toxicity studies
D Bovard, A Sandoz, A Iskandar, K Trivedi, K Luettich, S Frentzel, J Hoeng
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Poster
September 17, 2020
Heated Tobacco Products
Compilation of in vitro studies evaluating the impact of exposure to aerosols from heated tobacco products and an electronic vapor device on oral health and dental esthetics.
F Zanetti, A Nussbaum, A Iskandar, X Zhao, Y Ren*, S Majeed, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
September 12, 2020
A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products
A Sewer, F Zanetti, A Iskandar, E Guedj, R Dulize, D Peric, D Bornand, C Mathis, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2020.09.001
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Peer-Reviewed Publication
September 12, 2020
Heated Tobacco Products
Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case
W Schlage, B Titz, A Iskandar, C Poussin, M Van der Toorn, E T Wong, P Pratte, S Maeder, JP Schaller, P Pospisil, S Boue, G Vuillaume, P Leroy, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2020.09.004
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Peer-Reviewed Publication
September 4, 2020
Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors
D Bovard, A Giralt, K Trivedi, L Neau, Petros Kanellos , A Iskandar, A Kondylis, K Luettich, S Frentzel, J Hoeng, M Peitsch
Current Research in Toxiocology
DOI : 10.1016/j.crtox.2020.08.002
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Peer-Reviewed Publication
August 24, 2020
Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis
P A Ruiz Castro, U Kogel, G Lo Sasso, B Phillips, A Sewer, B Titz, L Garcia, A Kondylis, E Guedj, D Peric, D Bornand, R Dulize, C Merg, M Corciulo, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1186/s12950-020-00260-6
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Peer-Reviewed Publication
August 11, 2020
Heated Tobacco Products
Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol from a Heated Tobacco Product Compared with Cigarette Smoke
E T Wong, K Luettich, S Krishnan, S K Wong, WT Lim, D Yeo, A Buettner*, P Leroy, G Vuillaume, S Boue, J Hoeng, P Vanscheeuwijck, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1093/toxsci/kfaa131
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Peer-Reviewed Publication
August 7, 2020
Inflammatory Bowel Disease–Associated Changes in the Gut: Focus on Kazan Patients
G Lo Sasso, L Khachatryan, A Kondylis, JND Battey, N Sierro, NA Danilova*, TV Grigoryeva*, MI Markelova*, DR Khusnutdinova*, AV Laikov*, II Salafutdinov*, YD Romanova*, MN Siniagina*, IY Vasiliev*, EA Boulygina*, VV Solovyeva*, EE Garanina*, KV Kitaeva*, KY Ivanov*, DS Chulpanova*, KS Kletenkov*, AR Valeeva*, A Kh Odintsova*, MD Ardatskaya*, RA Abdulkhakov*, NV Ivanov, M Peitsch, J Hoeng, SR Abdulkhakov*
* This author is not affiliated with PMI.DOI : 10.1093/ibd/izaa188
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Poster
July 20, 2020
Are metagenomics data sufficiently informative for potential non-invasive diagnosis of inflammatory bowel disease status — Outcomes of the crowdsourced sbv IMPROVER MEDIC challenge
C Poussin, L Khachatryan, Y Xiang, A Stan, JND Battey, G Lo Sasso, S Boue, M Peitsch, J Hoeng
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Peer-Reviewed Publication
July 15, 2020
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
U Marx*, T. Akabane *, TB Andersson *, E. Baker *, M Beilmann*, S Beken*, S. Brendler-Schwaab*, M Cirit*, R. David *, E-M Dehne*, I. Durieux *, L. Ewart *, SC Fitzpatrick*, O Frey*, F Fuchs *, L Griffith *, G Hamilton *, T Hartung*, J Hoeng, H Hogberg *, DJ Hughes *, DE Ingber *, A Iskandar, T Kanamori *, H Kojima*, J Kuehnl*, M Leist*, B Li *, P Loskill *, DL Mendrick *, T Neumann *, G Pallocca *, I Rusyn *, L Smirnova*, T Steger-Hartmann*, DA Tagle*, A Tonevitsky *, S Tsyb*, M Trapecar*, BVD Water *, JVD Eijnden-van Raaij*, P Vulto*, K Watanabe*, A Wolf*, X Zhou*, A Roth*
* This author is not affiliated with PMI.DOI : 10.14573/altex.2001241
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Poster
July 12, 2020
Heated Tobacco Products
Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Disease: Translating Basic Science into Clinical Benefit
G Baker, G de La Bourdonnaye, A Elamin, C Goujon-Ginglinger, C Haziza, A Heremans, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, B Phillips, P Picavet, S Pouly, C Poussin, P Pratte, CT Tran, P Vanscheeuwijck, M Peitsch
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Peer-Reviewed Publication
July 8, 2020
Systems toxicology approach for testing chemical cardiotoxicity in larval zebrafish
R Li*, A. Zupanic*, M Talikka, V Belcastro, S Madan*, J. Dörpinghaus*, C. vom Berg*, J Szostak, F Martin, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Chemical Research in Toxicology
DOI : 10.1021/acs.chemrestox.0c00095
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Peer-Reviewed Publication
June 24, 2020
An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes
L Gijzen*, D Marescotti, E Raineri*, A Nicolas*, HL Lanz*, D Guerrera, R van Vught*, J Joore*, P Vulto*, M Peitsch, J Hoeng, G Lo Sasso, D Kurek*
* This author is not affiliated with PMI.DOI : 10.1177/2472630320924999
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Peer-Reviewed Publication
June 10, 2020
Heated Tobacco Products
Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GC–MS deconvolution procedures
A Haiduc, F Zanetti, X Zhao, W Schlage, M Scherer*, N Pluym*, P Schlenger*, NV Ivanov, S Majeed, J Hoeng, M Peitsch, Y Ren*, P A. Guy*
* This author is not affiliated with PMI.DOI : 10.1016/j.jchromb.2020.122228
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Peer-Reviewed Publication
June 5, 2020
Development and testing of a new-generation aerosol exposure system: The independent holistic air-liquid exposure system (InHALES)
S Steiner, P Herve, C Pak, S Majeed, A Sandoz, A Kuczaj, J Hoeng
DOI : 10.1016/j.tiv.2020.104909
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Poster
June 1, 2020
Monitoring of exogenous compound kinetics in exhaled breath
T Zikovic Semren, C Laszlo, M Gomez*, G Vidal-de-Miguel*, J Hoeng, M Peitsch, NV Ivanov, P A. Guy*
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
May 14, 2020
Nicotine-Containing E-Vapor Products
E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model
MK Reumann*, J Schaefer*, B Titz, RH Aspera-Werz*, E T Wong, J Szostak, V Häussling*, S Ehnert*, P Leroy, W Teck Tan, A Kuczaj, C Audretsch*, F Springer*, A Badke*, P Augat*, L Quentanilla-Fend*, M Martella*, K M Lee*, M Peitsch, J Hoeng, AK Nussler*
* This author is not affiliated with PMI.DOI : 10.1007/s00204-020-02769-4