About Patrick
I am leading the group that defines the clinical assessment strategy, scientifically oversees and conducts clinical research to scientifically substantiate the risk reduction potential of our candidate Reduced-Risk Products.
Latest Publications
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Publication
July 3, 2019
Heated Tobacco Products
Effects of switching to a heat-not-burn tobacco product on biologically-relevant biomarkers to assess a candidate modified risk tobacco product: a randomized trial
F Lüdicke, M S Ansari, N Lama, N Blanc, M Bosilkovska, A Donelli, P Picavet, G Baker, C Haziza, M Peitsch, R Weitkunat
Cancer Epidemiology, Biomarkers & Prevention
DOI : 10.1158/1055-9965.EPI-18-0915
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Publication
June 14, 2019
One year of continuous smoking abstinence: a study on biological and functional changes in healthy adult smokers
Loyse Felber Medlin , CT Tran, W Teck Ng, N Lama, BV Taranu, E Pierri, P Picavet, G Baker, C Haziza, F Lüdicke
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Peer-Reviewed Publication
June 7, 2019
Heated Tobacco Products
Biological and functional changes in healthy adult smokers who are continuously abstinent from smoking for one year: Protocol for a prospective, observational, multicenter cohort study
CT Tran, Loyse Felber Medlin , N Lama, BV Taranu, W Teck Ng, C Haziza, P Picavet, G Baker, F Lüdicke
DOI : 10.2196/12138
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Publication
May 24, 2019
Heated Tobacco Products
Favorable Changes in Biomarkers of Potential Harm to Reduce the Adverse Health Effects of Smoking in Smokers Switching to the Menthol Tobacco Heating System 2.2 for Three Months (Part 2)
C Haziza, G de La Bourdonnaye, A Donelli, D Skiada, V Poux, R Weitkunat, G Baker, P Picavet, F Lüdicke
DOI : 10.1093/ntr/ntx028
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Report
March 20, 2019
Platform 1
Summary of Evidence of Effects of IQOS on Endothelial function
G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch
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Poster
February 22, 2019
A Multicenter, Multiregional Study on Biological and Functional Changes in Healthy Adult Smokers During One Year of Continuous Smoking Abstinence
Loyse Felber Medlin , CT Tran, W Teck Ng, N Lama, BV Taranu, E Pierri, P Picavet, G Baker, C Haziza, F Lüdicke
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Peer-Reviewed Publication
February 5, 2019
Platform 1
Reduction In Exposure To Selected Harmful And Potentially Harmful Constituents Approaching Those Observed Upon Smoking Abstinence In Smokers Switching To The Menthol Tobacco Heating System 2.2 For Three Months (Part 1)
C Haziza, G de La Bourdonnaye, A Donelli, V Poux, D Skiada, R Weitkunat, G Baker, P Picavet, F Lüdicke
DOI : 10.1093/ntr/ntz013
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Report
January 22, 2019
Platform 1
Scientific substantiation of the absence of combustion and no smoke formation in the Electrically Heated Tobacco Product (EHTP)
M Nordlund, M Smith, S Maeder, T McGrath, JP Schaller, P Pratte, P Picavet, M Peitsch
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Report
December 10, 2018
Platform 1
Summary of Evidence: Cytotoxic Effects on Bronchial Epithelial Cells
G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch
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Report
November 20, 2018
Platform 1
Summary of the Evidence: Pulmonary and Immunosuppressive Effects of IQOS
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Presentation
November 19, 2018
Platform 1
Respiratory Effects Observed When Using the Tobacco Heating System (THS) Compared with Continued Smoking
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Poster
September 17, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Peer-Reviewed Publication
August 24, 2018
Platform 1
Evaluation of Biological and Functional Changes in Healthy Smokers Switching to the Tobacco Heating System 2.2 Versus Continued Tobacco Smoking: Protocol for a Randomized, Controlled, Multicenter Study
M S Ansari, N Lama, N Blanc, M Bosilkovska, A Donelli, P Picavet, G Baker, C Haziza, F Lüdicke
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Infoposter
June 15, 2018
A Multi-Center, Multi-Regional, Study on Biological and Functional Changes in Healthy Adult Smokers during One Year of Continuous Smoking Abstinence
C Tran, Loyse Felber Medlin , N Lama, BV Taranu, E Pierri, J Ancerewicz, P Picavet, G Baker, C Haziza, F Lüdicke
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Infoposter
June 15, 2018
Evaluation of biological and functional changes in healthy smokers after switching from cigarettes to Tobacco Heating System (THS) 2.2 for 6 months
S Ansari, N Lama, N Blanc, D Skiada, J Ancerewicz, P Picavet, G Baker, C Haziza, F Lüdicke
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Poster
June 11, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Poster
June 11, 2018
Platform 1
Changes in Clinical Risk Endpoints Linked to Cardiovascular and Other Smoking-Related Diseases after Switching from Cigarettes to the Tobacco Heating System (THS) 2.2 for Six Months
C Haziza, S Ansari, N Lama, M Bosilkovska, N Blanc, D Skiada, J Ancerewicz, P Picavet, G Baker, F Lüdicke
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Poster
May 9, 2018
Human Research Investigation on the Effects of Cigarette Smoking, E-Cigarette Vaping, and Smoking Cessation on Vascular Cell Biology
C Poussin, J Hoeng, S Ansari, E Guedj, TM Curran*, LA Baglia*, RA Berg*, N Blumberg*, SL Spinelli*, Loyse Felber Medlin , NV Ivanov, P Picavet, M Peitsch
* This author is not affiliated with PMI. -
Poster
February 26, 2018
A multi-center multiregional study on biological and functional changes in healthy adult smokers during one year of continuous smoking abstinence
C Tran, Loyse Felber Medlin , N Lama, BV Taranu, E Pierri, J Ancerewicz, P Picavet, G Baker, C Haziza, F Lüdicke
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Peer-Reviewed Publication
July 29, 2017
Platform 1
Nicotine pharmacokinetic profiles of the Tobacco Heating System 2.2, cigarettes and nicotine gum in Japanese smokers
P Brossard, R Weitkunat, V Poux, N Lama, C Haziza, P Picavet, G Baker, F Lüdicke
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Peer-Reviewed Publication
February 8, 2017
Platform 1
Effects of Switching to the Tobacco Heating System 2.2 Menthol, Smoking Abstinence, or Continued Cigarette Smoking on Biomarkers of Exposure: A Randomized, Controlled, Open-Label, Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 1)
F Lüdicke, P Picavet, G Baker, C Haziza, V Poux, N Lama, R Weitkunat
DOI : 10.1093/ntr/ntw287
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Peer-Reviewed Publication
February 8, 2017
Platform 1
Effects of Switching to Menthol THS2.2, Smoking Abstinence, or Continued Cigarette Smoking on Clinically Relevant Risk Markers: A Randomized, Controlled, Open-Label, Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 2)
F Lüdicke, P Picavet, G Baker, C Haziza, V Poux, N Lama, R Weitkunat
DOI : 10.1093/ntr/ntx028
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Publication
February 1, 2017
Heated Tobacco Products
Biomarker of exposure level data set in smokers switching from conventional cigarettes to Tobacco Heating System 2.2, continuing smoking or abstaining from smoking for 5 days
C Haziza, G de La Bourdonnaye, D Skiada, J Ancerewicz, G Baker, P Picavet, F Lüdicke
DOI : 10.1016/j.dib.2016.11.047
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Peer-Reviewed Publication
January 4, 2017
Platform 1
Biomarker of exposure level data set in smokers switching from conventional cigarettes to Tobacco Heating System 2.2, continuing smoking or abstaining from smoking for 5 days
C Haziza, G de La Bourdonnaye, D Skiada, J Ancerewicz, G Baker, P Picavet, F Lüdicke
DOI : 10.1016/j.dib.2016.11.047
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Peer-Reviewed Publication
November 4, 2016
Platform 1
Evaluation of the Tobacco Heating System 2.2. Part 8: 5-Day randomized reduced exposure clinical study in Poland
C Haziza, G de La Bourdonnaye, D Skiada, J Ancerewicz, G Baker, P Picavet, F Lüdicke
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.11.003
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Presentation
October 8, 2016
Platform 1
THS2.2 – A Heat-not-Burn Product - Scientific Results to Date
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Peer-Reviewed Publication
September 29, 2016
Platform 1
Assessment of the reduction in levels of exposure to harmful and potentially harmful constituents in Japanese subjects using a novel tobacco heating system compared with conventional cigarettes and smoking abstinence: A randomized controlled study in confinement
C Haziza, G de La Bourdonnaye, S Merlet, M Benzimra, J Ancerewicz, A Donelli, G Baker, P Picavet, F Lüdicke
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2016.09.014
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Poster
September 9, 2016
Platform 1
Reduced exposure to Harmful and Potentially Harmful Constituents after 90 days of use of tobacco heating system 2.2 in Japan: a comparison with continued cigarette use or smoking abstinence
F Lüdicke, C Haziza, N Lama, A Donelli, G Baker, J Ancerewicz, M Benzimra, M Franzon, M Endo*, P Picavet
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 1, 2016
Platform 1
Reduced Exposure to Harmful and Potentially Harmful Smoke Constituents with the Tobacco Heating System 2.1
DOI : 10.1093/ntr/ntw164
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Poster
June 17, 2016
Heated Tobacco Products
Comparing the Levels of Harmful Compounds in Smokers that either Continue to Smoke, Quit or Switch to THS2.2 Menthol (Japan)
C Haziza, N Lama, A Donelli, P Picavet, G Baker, J Ancerewicz, M Benzimra, M Franzon, M Endo*, F Lüdicke
* This author is not affiliated with PMI. -
Poster
June 17, 2016
Heated Tobacco Products
Comparing The Levels Of Harmful Compounds In Smokers That Either Continue To Smoke, Quit Or Switch To THS2.2 Menthol (USA)
C Haziza, G de La Bourdonnaye, P Picavet, G Baker, D Skiada, S Merlet, M Franzon, F Farmer, W Lewis, F Lüdicke
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Infoposter
June 16, 2016
Platform 1
Comparing the levels of harmful compounds in smokers that either continue to smoke, quit or switch to THS2.2 menthol
C Haziza, N Lama, A Donelli, P Picavet, G Baker, J Ancerewicz, M Benzimra, M Franzon, M Endo*, F Lüdicke
* This author is not affiliated with PMI. -
Poster
November 10, 2015
Reduced Exposure To Harmful And Potentially Harmful Constituents after 90 Days Of Use Of Tobacco Heating System 2.2 Menthol In Japan: A Comparison With Continued Cigarette Use Or Smoking Abstinence
C Haziza, N Lama, P Picavet, G Baker, J Ancerewicz, M Benzimra, M Franzon, M Endo*, F Lüdicke
* This author is not affiliated with PMI. -
Poster
November 10, 2015
Heated Tobacco Products
Reduced exposure to harmful and potentially harmful constituents after 90 days of use of tobacco heating system 2.2 menthol in the U.S.: a comparison with continued cigarette use or smoking abstinence
C Haziza, G de La Bourdonnaye, P Picavet, G Baker, D Skiada, S Merlet, M Franzon, F Farmer, W Lewis, F Lüdicke
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Peer-Reviewed Publication
October 5, 2015
Platform 1
Comparison of the Pharmacokinetics of Nicotine Following Single and Ad Libitum Use of a Tobacco Heating System or Combustible Cigarettes
DOI : 10.1093/ntr/ntv220
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Poster
March 23, 2015
Heated Tobacco Products
PK of Nicotine and Subjective Effects Following the Single Use of a Non-Menthol and Menthol Version of THS 2.2 in 2 Studies in Japan. A Comparison with Single Use of a Combustible Cigarette and Nicotine Gum
P Picavet, C Haziza, G Baker, N Lama, J Ancerewicz, M Benzimra, F Nobuoka*, M Sugimoto*, F Lüdicke
* This author is not affiliated with PMI. -
Poster
March 23, 2015
Heated Tobacco Products
Reduced Exposure To Harmful And Potentially Harmful Constituents After Five Days of Use of Tobacco Heating System 2.2. A Comparison with Continued Combustible Cigarette Use or Smoking Abstinence [Poland]
C Haziza, G de La Bourdonnaye, P Picavet, G Baker, D Skiada, J Ancerewicz, K Jarus-Dziedzic*, F Lüdicke
* This author is not affiliated with PMI. -
Poster
February 28, 2015
Platform 1
Investigation on puffing topography parameters and product evaluation recorded during five days of use of the Tobacco Heating System 2.2: A comparison with continued combustible cigarette use
G de La Bourdonnaye, T Bachmann, C Haziza, P Picavet, G Baker, D Skiada, K Jarus-Dziedzic*, F Lüdicke
* This author is not affiliated with PMI. -
Poster
February 28, 2015
Heated Tobacco Products
Pharmacokinetics Of Nicotine And Subjective Effects Following The Single Use Of A Menthol Version Of Tobacco Heating System 2.2 In The US: A Comparison With Single Use Of A Combustible Cigarette And Nicotine Nasal Spray
C Haziza, G Baker, G de La Bourdonnaye, N Lama, J Ancerewicz, D Skiada, P Picavet, JL Borders*, F Lüdicke
* This author is not affiliated with PMI. -
Poster
February 28, 2015
Heated Tobacco Products
Reduced Exposure To Harmful And Potentially Harmful Constituents After Five Days Of Use Of tobacco Heating System 2.2: A Comparison With Continued Combustible Cigarette Use Or Smoking Abstinence [Japan]
C Haziza, G de La Bourdonnaye, G Baker, M Benzimra, J Ancerewicz, P Picavet, F Lüdicke
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Poster
February 28, 2015
Platform 1
Pharmacokinetics Of Nicotine And Subjective Effects Following The Single Use Of A Non-Menthol And Menthol Version Of Tobacco Heating System 2.2 In Two Studies In Japan: A Comparison With Single Use Of A Combustible Cigarette And Nicotine Gum
P Picavet, C Haziza, G Baker, N Lama, J Ancerewicz, M Benzimra, F Nobuoka*, M Sugimoto*, F Lüdicke
* This author is not affiliated with PMI. -
Poster
February 4, 2014
Platform 1
Pharmacokinetics of nicotine following single use of a candidate modified risk tobacco product: the tobacco heating system 2.1
C Haziza, G Baker, J Ancerewicz, P Picavet, L Johnson, AJ Stewart*, F Lüdicke
* This author is not affiliated with PMI.