About Manuel
As the Chief Science Officer at Philip Morris International, I am focused on the science behind Heated Tobacco Products and e-cigarettes to drive Tobacco Harm Reduction. I stand for scientific excellence, executed to the highest standards of quality as well as for scientific transparency and verification.
I have many years of experience leading large multi-cultural research teams in systems biology and toxicology, scientific computing (bio- and chemo-informatics), text mining and molecular biology.
I hold several patents related to proteomics, genomics and scientific computing, and I’ve published over 250 articles, book chapters and technical reports. My publications have been cited over 27,000 times and I’ve done groundbreaking research into computational structural biology, text mining and systems toxicology.
I founded two start-up companies, the [BC]2 conference, and the Swiss Institute of Bioinformatics, where I serve as the chairman of the board.
Academically, I hold a BSc in Life Sciences, a MSc in Physical Chemistry and a PhD in Biochemistry, while I’m also an Adjunct Professor for Bioinformatics at the University of Basel.
Among the honors I’ve received are the New England Business and Technology Award and the UnitedDevices Grid Visionary Award. I’m also a ComputerWorld Honors Laureate.
Latest Publications
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Peer-Reviewed Publication
February 18, 2020
Alternatives to Animal Use in Risk Assessment of Mixtures
AW Hayes, A Muriana*, A Alzualde*, DB Fernandez*, A Iskandar, M Peitsch, A Kuczaj, J Hoeng
* This author is not affiliated with PMI.International Journal of Toxicology
DOI : 10.1177/1091581820905088
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Peer-Reviewed Publication
January 24, 2020
Nicotine-Containing E-Vapor Products
A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke
J Szostak, E T Wong, B Titz, T Lee, S K Wong, T Low, KM Lee*, J Zhang*, A Kumar*, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, Y Xiang, F Martin, A Sewer, A Kuczaj, NV Ivanov, K Luettich, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.American Journal of Physiology - Heart and Circulatory Physiology
DOI : 10.1152/ajpheart.00613.2019
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Peer-Reviewed Publication
January 23, 2020
In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures
D Marescotti, D Bovard, M Morelli, A Sandoz, K Luettich, S Frentzel, M Peitsch, J Hoeng
SLAS TECHNOLOGY: Translating Life Sciences Innovation
DOI : 10.1177/2472630319895473
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Peer-Reviewed Publication
January 21, 2020
Platform 1
State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-not-burn tobacco products
S Boue, D Goedertier, J Hoeng, A Kuczaj, S Majeed, C Mathis, A May*, B Phillips, M Peitsch, F Radtke, W Schlage, W Teck Tan, P Vanscheeuwijck
* This author is not affiliated with PMI.Toxicology Research and Application
DOI : 10.1177/2397847319897869
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Peer-Reviewed Publication
January 6, 2020
Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond
Critical Reviews in Toxicology
DOI : 10.1080/10408444.2019.1692780
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Peer-Reviewed Publication
December 21, 2019
Applying Systems Toxicology Methods to Drug Safety
M Talikka, V Belcastro, S Boue, D Marescotti, J Hoeng, M Peitsch
DOI : 10.1016/B978-0-12-801238-3.11522-3
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Peer-Reviewed Publication
December 19, 2019
An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors
O Alijevic, D McHugh, L Rufener*, A Mazurov, J Hoeng, M Peitsch
* This author is not affiliated with PMI.DOI : 10.1016/j.phytochem.2019.112187
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Peer-Reviewed Publication
November 25, 2019
Nicotine-Containing E-Vapor Products
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.toxrep.2019.11.016
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Peer-Reviewed Publication
November 15, 2019
Neurobehavioral effects of selected tobacco constituents in rodents following subchronic administration
European Journal of Pharmacology
DOI : 10.1016/j.ejphar.2019.172809
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Peer-Reviewed Publication
November 13, 2019
Heated Tobacco Products
Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products
M Van der Toorn, K Koshibu, W Schlage, S Majeed, P Pospisil, J Hoeng, M Peitsch
DOI : 10.1016/j.toxrep.2019.11.008
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Peer-Reviewed Publication
November 6, 2019
Heated Tobacco Products
Structural, functional, and molecular impact on the cardiovascular system in ApoE−/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke
J Szostak, B Titz, W Schlage, E Guedj, B Phillips, P Leroy, A Buettner*, L Neau, K Trivedi, F Martin, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Chemico-Biological Interactions
DOI : 10.1016/j.cbi.2019.108887
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Peer-Reviewed Publication
September 9, 2019
Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles
DOI : 10.1080/08958378.2019.1662526
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Peer-Reviewed Publication
September 7, 2019
Nicotine-Containing E-Vapor Products
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology
A Iskandar, F Zanetti, D Marescotti, B Titz, A Sewer, A Kondylis, P Leroy, V Belcastro, L Ortega Torres, S Acali, S Majeed, S Steiner, K Trivedi, E Guedj, C Merg, T Schneider, S Frentzel, F Martin, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1007/s00204-019-02565-9
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Peer-Reviewed Publication
September 3, 2019
NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks
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Peer-Reviewed Publication
August 22, 2019
Heated Tobacco Products
3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow – application in systems toxicology
C Poussin, B Kramer*, HL Lanz*, A van den Heuvel*, A Laurent, T Olivier*, M Vermeer*, D Peric, K Baumer, R Dulize, E Guedj, NV Ivanov, M Peitsch, J Hoeng, J Joore*
* This author is not affiliated with PMI.DOI : 10.14573/altex.1811301
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Peer-Reviewed Publication
August 17, 2019
Platform 4
Effects of different discoloration challenges and whitening treatments on dental hard tissues and composite resin restorations
X Zhao, F Zanetti, L Wang*, J Pan*, S Majeed, H Malmstrom*, M Peitsch, J Hoeng, Y Ren*
* This author is not affiliated with PMI.DOI : 10.1016/j.jdent.2019.103182
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Publication
July 3, 2019
Heated Tobacco Products
Effects of switching to a heat-not-burn tobacco product on biologically-relevant biomarkers to assess a candidate modified risk tobacco product: a randomized trial
F Lüdicke, M S Ansari, N Lama, N Blanc, M Bosilkovska, A Donelli, P Picavet, G Baker, C Haziza, M Peitsch, R Weitkunat
Cancer Epidemiology, Biomarkers & Prevention
DOI : 10.1158/1055-9965.EPI-18-0915
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Peer-Reviewed Publication
July 3, 2019
Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties
S Schorderet Weber, K P. Kaminski, JL Perret*, P Leroy, A Mazurov, M Peitsch, NV Ivanov, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.110660
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Poster
June 24, 2019
Untargeted Metabolomics Application to Monitor Urine Samples by Ultra-High-Pressure Liquid Chromatography Coupled to High-Resolution Mass Spectrometry
C. Laszlo, A G Haiduc, M. Fatarova, E Dossin, F. de Jong*, C. Beecher*, A. Kamleh*, P Guy, NV Ivanov, M Peitsch
* This author is not affiliated with PMI. -
Poster
June 24, 2019
Prediction models of retention indices: application to gas chromatography coupled to high-resolution mass spectrometry for two column types: DB-624 and HP-5ms
A G Haiduc, E Dossin, P Diana, P Guy, NV Ivanov, M Peitsch
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Publication
June 22, 2019
Systems toxicology approach to unravel early indicators of squamous cell carcinoma rate in rat nasal epithelium induced by formaldehyde exposure
International Conference on Practical Applications of Computational Biology & Bioinformatics
DOI : 10.1007/978-3-030-23873-5_3
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Publication
June 13, 2019
Mitochondria as a possible target for nicotine action
D Malińska*, M Wieckowski*, B Michalska*, K Drabik*, M Prill*, P Patalas-Krawczyk*, J Walczak*, J Szymanski*, C Mathis, M Van der Toorn, K Luettich, J Hoeng, M Peitsch, J Duszynski*, J Szczepanowska*
* This author is not affiliated with PMI.Journal of Bioenergetics and Biomembranes
DOI : 10.1007/s10863-019-09800-z
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Poster
May 9, 2019
Characterization of the Vitrocell® Cloud SEQ 24 System and its Application in Exposure to Aerosolized Bortezomib and Ibuprofen
S Steiner, S Ferreira, M Morelli, A Baldi, A Kuczaj, S Frentzel, M Van der Toorn, M Peitsch, J Hoeng
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Peer-Reviewed Publication
April 11, 2019
Systems toxicology meta-analysis – from aerosol exposure to nanotoxicology
M Talikka, V Belcastro, S Gubian, F Martin, M Peitsch, J Hoeng
DOI : 10.1016/j.cotox.2019.03.010
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Presentation
April 9, 2019
A method for determination of tracheobronchial airway geometries from four different strains of mice
J Hoeng, C Foong, F Lucci, D Yeo, J Chua, A Kuczaj, M Peitsch
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Presentation
March 27, 2019
Assessment of potential neuroprotective effects of alkaloids in a human dopaminergic in vitro model of Parkinson’s disease
MB Fares, C Mathis, A Kondylis, O Alijevic, N Sierro, J Hoeng, M Peitsch
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Publication
March 26, 2019
Heated Tobacco Products
A meta-analysis of the performance of a blood-based exposure response gene signature across clinical studies on the Tobacco Heating System 2.2 (THS 2.2)
F Martin, M Talikka, NV Ivanov, C Haziza, J Hoeng, M Peitsch
DOI : 10.3389/fphar.2019.00198
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Report
March 20, 2019
Platform 1
Summary of Evidence of Effects of IQOS on Endothelial function
G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch
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Peer-Reviewed Publication
March 18, 2019
Nicotine-Containing E-Vapor Products
Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
KM Lee*, J Hoeng, S Harbo*, U Kogel, W Gardner*, M J Oldham*, E Benson*, M Talikka, A Kondylis, F Martin, B Titz, S Ansari, K Trivedi, E Guedj, A Elamin, NV Ivanov, P Vanscheeuwijck, M Peitsch, WJ McKinney*
* This author is not affiliated with PMI.DOI : 10.1080/08958378.2019.1576807
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Peer-Reviewed Publication
March 18, 2019
Platform 1
Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review
Regulatory Toxicology and Pharmacology
DOI : 10.1016/j.yrtph.2019.03.007
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Peer-Reviewed Publication
March 18, 2019
GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology
V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1093/bioinformatics/btz187
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Presentation
March 16, 2019
Platform 1
Cardiovascular Effects of the Tobacco Heating System (THS) Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, C Poussin, P Vanscheeuwijck
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Poster
March 12, 2019
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D Marescotti, C Mathis, V Belcastro, P Leroy, S Acali, F Martin, R Dulize, D Bornand, K Baumer, D Peric, E Guedj, L Ortega Torres, M Biasioli, M Fuhrimann, E Fernandes, F Frauendorfer, K Luettich, I Gonzalez-Suarez, D Sciuscio, NV Ivanov, M Peitsch, J Hoeng
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Poster
March 12, 2019
Heated Tobacco Products
Xenobiotic metabolism response to 3R4F or THS2.2 exposure: from pre-clinical to clinical
S Pouly, M Talikka, A van der Plas, B Titz, A Iskandar, G de La Bourdonnaye, N Blanc, F Martin, C Haziza, NV Ivanov, F Lüdicke, J Hoeng, M Peitsch
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Publication
March 12, 2019
Nicotine-Containing E-Vapor Products
Exposure to an aerosol from a novel electronic cigarette using the MESH™ technology elicited reduced biological impacts than exposure to cigarette smoke on buccal and small airway epithelial cultures: a systems toxicology assessment
A Iskandar, F Zanetti, A Kondylis, F Martin, A Sewer, L Ortega Torres, S Majeed, S Steiner, E Guedj, C Merg, T Schneider, K Trivedi, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
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Publication
March 12, 2019
A method for determination of tracheobronchial airway geometries from four different strains of mice
C Foong, M J Oldham*, F Lucci, S. Cockram*, S. Luke*, D Yeo, J Chua, J Hoeng, M Peitsch, A Kuczaj
* This author is not affiliated with PMI. -
Poster
March 12, 2019
GladiaTOX: global assessment of dose-response indicators in toxicology
V Belcastro, S Cano, D Marescotti, S Acali, I Gonzalez-Suarez, F Martin, F Bonjour, NV Ivanov, M Peitsch, J Hoeng
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Publication
March 12, 2019
Nicotine-Containing E-Vapor Products
Comparison of the impacts of an acute exposure to electronic cigarette aerosol and cigarette smoke on small airway epithelial cultures: In vitro systems toxicology assessment
A Iskandar, A Kondylis, F Martin, S Steiner, S Majeed, P Leroy, E Guedj, C Merg, K Trivedi, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
March 5, 2019
Platform 4
A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment
A Iskandar, F Zanetti, A Kondylis, F Martin, P Leroy, S Majeed, S Steiner, Y Xiang, L Ortega Torres, K Trivedi, E Guedj, C Merg, S Frentzel, NV Ivanov, U Doshi*, KM Lee*, WJ McKinney*, M Peitsch, J Hoeng
* This author is not affiliated with PMI.Internal and Emergency Medicine
DOI : 10.1007/s11739-019-02055-x
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Poster
February 28, 2019
Platform 1
Chronic Toxicity and Lung Carcinogenicity in A/J Mice Following Lifetime Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
K Luettich, E T Wong, K Trivedi, E Guedj, T Schneider, C Nury, B Titz, Y Xiang, P Leroy, G Vuillaume, P Vanscheeuwijck, NV Ivanov, M Peitsch, J Hoeng
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Poster
February 21, 2019
Systems Toxicology Assessment of Repeated Exposure of Human Organotypic Gingival Cultures to Swedish Snus Extracts and Total Particulate Matter from Cigarette Smoke
F Zanetti, A Sewer, B Titz, A Iskandar, A Kondylis, L Ortega Torres, C Pak, F Martin, E Guedj, K Trivedi, S Frentzel, NV Ivanov, J Hoeng, M Peitsch
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Peer-Reviewed Publication
February 15, 2019
Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract
H Yepiskoposyan, M Talikka, S Vavassori, F Martin, A Sewer, S Gubian, K Luettich, M Peitsch, J Hoeng
DOI : 10.3389/fgene.2019.00087
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Peer-Reviewed Publication
February 14, 2019
Platform 1
Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products
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Peer-Reviewed Publication
February 12, 2019
How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models
D Marescotti, T Serchi*, K Luettich, Y Xiang, E Moschini*, M Talikka, F Martin, K Baumer, R Dulize, D Peric, D Bornand, E Guedj, A Sewer, S Cambier*, S Contal*, A Chary*, AC Gutleb*, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.ALTEX Alternatives to Animal Experimentation
DOI : 10.14573/altex.1811221
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Peer-Reviewed Publication
February 12, 2019
Heated Tobacco Products
A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes
B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, MA Choukrallah, T Schneider, NV Ivanov, C Teng, CK Tung, YS Yeo, P Vanscheeuwijck, M Peitsch, J Hoeng, WT Lim
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.02.008
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Peer-Reviewed Publication
February 7, 2019
Platform 1
Epigenomics in tobacco risk assessment: Opportunities for integrated new approaches
MA Choukrallah, A Sewer, M Talikka, N Sierro, M Peitsch, J Hoeng, NV Ivanov
DOI : 10.1016/j.cotox.2019.01.001