About Manuel
As the Chief Science Officer at Philip Morris International, I am focused on the science behind Heated Tobacco Products and e-cigarettes to drive Tobacco Harm Reduction. I stand for scientific excellence, executed to the highest standards of quality as well as for scientific transparency and verification.
I have many years of experience leading large multi-cultural research teams in systems biology and toxicology, scientific computing (bio- and chemo-informatics), text mining and molecular biology.
I hold several patents related to proteomics, genomics and scientific computing, and I’ve published over 250 articles, book chapters and technical reports. My publications have been cited over 27,000 times and I’ve done groundbreaking research into computational structural biology, text mining and systems toxicology.
I founded two start-up companies, the [BC]2 conference, and the Swiss Institute of Bioinformatics, where I serve as the chairman of the board.
Academically, I hold a BSc in Life Sciences, a MSc in Physical Chemistry and a PhD in Biochemistry, while I’m also an Adjunct Professor for Bioinformatics at the University of Basel.
Among the honors I’ve received are the New England Business and Technology Award and the UnitedDevices Grid Visionary Award. I’m also a ComputerWorld Honors Laureate.
Latest Publications
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Poster
February 21, 2019
Systems Toxicology Assessment of Repeated Exposure of Human Organotypic Gingival Cultures to Swedish Snus Extracts and Total Particulate Matter from Cigarette Smoke
F Zanetti, A Sewer, B Titz, A Iskandar, A Kondylis, L Ortega Torres, C Pak, F Martin, E Guedj, K Trivedi, S Frentzel, NV Ivanov, J Hoeng, M Peitsch
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Peer-Reviewed Publication
February 15, 2019
Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract
H Yepiskoposyan, M Talikka, S Vavassori, F Martin, A Sewer, S Gubian, K Luettich, M Peitsch, J Hoeng
DOI : 10.3389/fgene.2019.00087
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Peer-Reviewed Publication
February 14, 2019
Platform 1
Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products
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Peer-Reviewed Publication
February 12, 2019
How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models
D Marescotti, T Serchi*, K Luettich, Y Xiang, E Moschini*, M Talikka, F Martin, K Baumer, R Dulize, D Peric, D Bornand, E Guedj, A Sewer, S Cambier*, S Contal*, A Chary*, AC Gutleb*, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
* This author is not affiliated with PMI.ALTEX Alternatives to Animal Experimentation
DOI : 10.14573/altex.1811221
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Peer-Reviewed Publication
February 12, 2019
Heated Tobacco Products
A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes
B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, A Choukrallah, T Schneider, NV Ivanov, Charles Teng, CK Tung, YS Yeo, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2019.02.008
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Peer-Reviewed Publication
February 7, 2019
Platform 1
Epigenomics in tobacco risk assessment: Opportunities for integrated new approaches
A Choukrallah, A Sewer, M Talikka, N Sierro, M Peitsch, J Hoeng, NV Ivanov
DOI : 10.1016/j.cotox.2019.01.001
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Report
January 22, 2019
Platform 1
Scientific substantiation of the absence of combustion and no smoke formation in the Electrically Heated Tobacco Product (EHTP)
M Nordlund, M Smith, S Maeder, T McGrath, JP Schaller, P Pratte, P Picavet, M Peitsch
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Peer-Reviewed Publication
January 3, 2019
Platform 1
New approaches to risk assessment of chemical mixtures.
AW Hayes, R Li*, J Hoeng, A Iskandar, M Peitsch, ML Dourson*
* This author is not affiliated with PMI.Toxicology Research and Application
3: 2397847318820768
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Peer-Reviewed Publication
January 2, 2019
Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarettes on gingival organotypic cultures.
F Zanetti, A Sewer, B Titz, W Schlage, A Iskandar, A Kondylis, P Leroy, E Guedj, K Trivedi, A Elamin, F Martin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.12.056
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Peer-Reviewed Publication
December 18, 2018
Platform 1
Effects of cigarette smoke and tobacco heating aerosol on color stability of dental enamel, dentin, and composite resin restorations.
F Zanetti, X Zhao, J Pan*, M Peitsch, J Hoeng, Y Ren*
* This author is not affiliated with PMI.DOI : 10.3290/j.qi.a41601
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Poster
December 17, 2018
Establishing the Vitrocell® Powder Chamber as a particle size-selective platform for in vitro dry powder testing
S Steiner, M Hittinger*, K Knoth*, H Gross*, S Frentzel, A Kuczaj, J Hoeng, T Krebs*, M Peitsch
* This author is not affiliated with PMI. -
Report
December 10, 2018
Platform 1
Summary of Evidence: Cytotoxic Effects on Bronchial Epithelial Cells
G Baker, P Picavet, M Smith, P Vanscheeuwijck, E Veljkovic, M Peitsch
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Poster
December 3, 2018
Platform 1
Toxicological evaluation of the Tobacco Heating System 2.2, a candidate modified risk tobacco product in a OECD inhalation study complemented with systems toxicology
U Kogel, E T Wong, B Titz, S Boue, A Elamin, G Vuillaume, P Leroy, NV Ivanov, P Vanscheeuwijck, J Hoeng, M Peitsch
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Peer-Reviewed Publication
November 29, 2018
The impact of genome evolution on the allotetraploid Nicotiana rustica – an intriguing story of enhanced alkaloid production
N Sierro, JND Battey, L Bovet, V Liedschulte, S Ouadi, J Thomas, Hervé Broye, H Laparra, A Vuarnoz, G Lang, S Goepfert, M Peitsch, NV Ivanov
DOI : 10.1186/s12864-018-5241-5
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Peer-Reviewed Publication
November 21, 2018
A lung/liver-on-a-chip platform for acute and chronic toxicity studies
D Bovard, A Sandoz, K Luettich, S Frentzel, A Iskandar, D Marescotti, K Trivedi, E Guedj, Q Dutertre, M Peitsch, J Hoeng
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Report
November 20, 2018
Platform 1
Summary of the Evidence: Pulmonary and Immunosuppressive Effects of IQOS
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Peer-Reviewed Publication
November 9, 2018
Platform 1
Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke
A Choukrallah, N Sierro, F Martin, K Baumer, J Thomas, S Ouadi, J Hoeng, M Peitsch, NV Ivanov
DOI : 10.1016/j.fct.2018.11.020
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Poster
October 5, 2018
Platform 1
Systems toxicology assessment of potential modified risk tobacco products: effects on lung, liver, and heart in ApoE -/- mice using iTRAQ
C Nury, B Phillips, J Szostak, B Titz, W Schlage, E Guedj, P Leroy, G Vuillaume, F Martin, A Buettner*, A Elamin, A Sewer, N Sierro, A Choukrallah, T Schneider, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
October 3, 2018
Embracing Transparency Through Data Sharing
S Boue, M Byrne*, AW Hayes, J Hoeng, M Peitsch
* This author is not affiliated with PMI.International Journal of Toxicology
DOI : 10.1177/1091581818803880
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Poster
September 27, 2018
Platform 1
Discriminating Spontaneous Tumors from Exposure Induced Tumors in the A/J Mouse Lung Cancer Model
Y Xiang, F Martin, K Luettich, K Trivedi, E Guedj, E T Wong, J Hoeng, M Peitsch
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Poster
September 21, 2018
Platform 1
Lung Inflammation, Emphysema, and Lung Cancer Development in A/J mice in Response to Chronic Exposure to Aerosol from a Candidate Modified Risk Tobacco Product and Mainstream Cigarette Smoke
E T Wong, K Luettich, K Trivedi, E Guedj, Y Xiang, A Elamin, B Titz, P Leroy, G Vuillaume, B Phillips, E Veljkovic, P Vanscheeuwijck, M Peitsch, J Hoeng
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Poster
September 17, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Poster
September 7, 2018
Platform 4
Systems Toxicology Assessment of Flavor Compounds Present in E-Vapor Products Using Human Primary Bronchial Epithelial Cells
D Marescotti, C Mathis, S Acali, V Belcastro, I Gonzalez-Suarez, S Frentzel, D Sciuscio, E Fernandes, M Biasioli, M Fuhrimann, F Frauendorfer, M Esposito, M Peitsch, J Hoeng
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Poster
September 6, 2018
Platform 1
Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Two Reduced-Risk Products Compared with Conventional Cigarettes
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
July 17, 2018
Platform 2
In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells
C Poussin, A Laurent, A Kondylis, D Marescotti, M Van der Toorn, E Guedj, D Goedertier, S Acali, C Pak, R Dulize, K Baumer, D Peric, E Maluenda, D Bornand, I Gonzalez-Suarez, W Schlage, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.07.025
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Poster
July 9, 2018
Crowdsourced-benchmarking of computational pipelines for metagenomic taxonomy profiling – the sbv IMPROVER Microbiomics Challenge
C Poussin, N Sierro, V Belcastro, JND Battey, S Boue, F Meyer*, E Scotti, A Petrelis, M Peitsch, NV Ivanov, J Hoeng
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
June 30, 2018
Advancing Risk Assessment through the Application of Systems Toxicology.
JM Sauer*, A Kleensang*, M Peitsch, AW Hayes
* This author is not affiliated with PMI. -
Poster
June 25, 2018
Platform 1
The impact of aerosol from Carbon Heated Tobacco Product 1.2 compared with cigarette smoke on the cardiovascular system of ApoE-/- mice in a six-month inhalation study
J Szostak, B Phillips, E Guedj, E T Wong, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Book Chapter
June 20, 2018
Developing Network-Based Systems Toxicology by Combining Transcriptomics Data with Literature Mining and Multiscale Quantitative Modeling
Bioinformatics in the Era of Post Genomics and Big Data
DOI : 10.5772/intechopen.75970
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Poster
June 11, 2018
Platform 1
Cardiovascular Effects Observed When Using the Tobacco Heating System (THS) 2.2 Compared with Continued Smoking
G Baker, C Haziza, J Hoeng, NV Ivanov, F Lüdicke, S Maeder, M Peitsch, B Phillips, P Picavet, C Poussin, P Vanscheeuwijck
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Book Chapter
May 23, 2018
Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases
Experimental Animal Models of Human Diseases: An Effective Therapeutic Strategy
DOI : 10.5772/intechopen.69569
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Poster
May 9, 2018
Platform 1
Systems Toxicological Assessment of two Modified Risk Tobacco Products on Cardiovascular and Respiratory Effects in ApoE-/-mice - a six-month inhalation study
B Phillips, J Szostak, E Guedj, E T Wong, M Talikka, S Lebrun, B Titz, F Martin, G Vuillaume, P Leroy, A Buettner*, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
* This author is not affiliated with PMI. -
Poster
May 9, 2018
Human Research Investigation on the Effects of Cigarette Smoking, E-Cigarette Vaping, and Smoking Cessation on Vascular Cell Biology
C Poussin, J Hoeng, S Ansari, E Guedj, TM Curran*, LA Baglia*, RA Berg*, N Blumberg*, SL Spinelli*, Loyse Felber Medlin , NV Ivanov, P Picavet, M Peitsch
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
May 7, 2018
Next-generation tobacco and nicotine products: Substantiating harm reduction and supporting tobacco regulatory science
M Peitsch, R Polosa*, C Proctor*, T Hassler*, M Gaca*, E Hill*, J Hoeng, AW Hayes
* This author is not affiliated with PMI. -
Peer-Reviewed Publication
April 11, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology
B Phillips, W Schlage, B Titz, U Kogel, D Sciuscio, F Martin, P Leroy, G Vuillaume, AS Krishnan *, PN Lee*, E Veljkovic, A Elamin, C Merg, NV Ivanov, M Peitsch, J Hoeng, P Vanscheeuwijck
* This author is not affiliated with PMI.DOI : 10.1016/j.fct.2018.04.015
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Poster
March 16, 2018
Platform 4
Systems Toxicology Assessment of Flavor Compounds Present in E-Vapor Products Using Human Primary Bronchial Epithelial Cells
D Marescotti, C Mathis, S Acali, V Belcastro, I Gonzalez-Suarez, S Frentzel, D Sciuscio, E Fernandes, M Biasioli, M Fuhrimann, F Frauendorfer, M Esposito, M Peitsch, J Hoeng
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Poster
March 16, 2018
Platform 1
Characterization of clones derived from human bronchial epithelial cells after long-term treatment with TPM from reference cigarettes versus THS 2.2
M Van der Toorn, M Sgandurra, D Marescotti, M Peitsch, J Hoeng, K Luettich
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Poster
March 16, 2018
Four-Week Continuous Nicotine Treatment of Immortalized Bronchial Epithelial Cells Does Not Contribute to Tumorigenesis
M Van der Toorn, K Baumer, D Peric, D Bornand, R Dulize, E Guedj, A Sewer, D Marescotti, K Luettich, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
March 13, 2018
Platform 2
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment
B Titz, U Kogel, F Martin, W Schlage, Y Xiang, C Nury, S Dijon, K Baumer, D Peric, D Bornand, R Dulize, B Phillips, P Leroy, G Vuillaume, S Lebrun, A Elamin, E Guedj, K Trivedi, NV Ivanov, P Vanscheeuwijck, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.058
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Poster
March 9, 2018
Platform 1
Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic nasal epithelial cultures - a view from the proteome
C Nury, A Iskandar, B Titz, P Leroy, T Schneider, S Dijon, C Merg, C Mathis, A Elamin, S Frentzel, W Schlage, F Martin, NV Ivanov, M Peitsch, J Hoeng
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Peer-Reviewed Publication
March 7, 2018
Physiological and biological characterization of smokers with and without COPD.
N Chaudhary, K Luettich, M Peck, E Pierri, Loyse Felber Medlin , G Vuillaume, P Leroy, J Hoeng, M Peitsch
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Peer-Reviewed Publication
March 7, 2018
Platform 1
The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product
M Van der Toorn, A Sewer, D Marescotti, S Johne, K Baumer, D Bornand, R Dulize, C Merg, M Corciulo, E Scotti, C Pak, P Leroy, E Guedj, NV Ivanov, F Martin, M Peitsch, J Hoeng, K Luettich
DOI : 10.1016/j.tiv.2018.02.019
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Peer-Reviewed Publication
March 2, 2018
Platform 2
Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens
F Zanetti, A Sewer, E Scotti, B Titz, W Schlage, P Leroy, A Kondylis, G Vuillaume, A Iskandar, E Guedj, K Trivedi, T Schneider, A Elamin, F Martin, NV Ivanov, S Frentzel, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.062
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Peer-Reviewed Publication
March 1, 2018
Platform 2
Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment
A Iskandar, F Martin, P Leroy, W Schlage, C Mathis, B Titz, A Kondylis, T Schneider, G Vuillaume, A Sewer, E Guedj, K Trivedi, A Elamin, S Frentzel, NV Ivanov, M Peitsch, J Hoeng
DOI : 10.1016/j.fct.2018.02.063
