Peer-Reviewed Publications

    Advancing risk assessment through the application of systems toxicology

    Sauer, J. M.; Kleensang, A.; Peitsch, M. C.; Hayes, A. W.
    Published
    Jan 31, 2016
    DOI
    10.5487/TR.2016.32.1.005
    PMID
    26977253
    Link to publication
    Topic
    Summary

    Risk assessment is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. Mechanistic approaches to risk assessment have been generally referred to as systems toxicology. Systems toxicology makes use of advanced analytical and computational tools to integrate classical toxicology and quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Three presentations including two case studies involving both in vitro and in vivo approaches described the current state of systems toxicology and the potential for its future application in chemical risk assessment.

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