Peer-Reviewed Publications

      Advancing risk assessment through the application of systems toxicology

      Sauer, J. M.; Kleensang, A.; Peitsch, M. C.; Hayes, A. W.
      Published
      Jan 31, 2016
      DOI
      10.5487/TR.2016.32.1.005
      PMID
      26977253
      Link to publication
      Topic
      Summary

      Risk assessment is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. Mechanistic approaches to risk assessment have been generally referred to as systems toxicology. Systems toxicology makes use of advanced analytical and computational tools to integrate classical toxicology and quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Three presentations including two case studies involving both in vitro and in vivo approaches described the current state of systems toxicology and the potential for its future application in chemical risk assessment.

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