Methods and Protocols

      Aerosol Droplet Size Distribution Measurement Instruments

      PMI

      Published on
      Oct 15, 2016
      Topic
      Summary

      One important aerosol property to be evaluated in RRP platforms – heated-tobacco platforms and e-cigarettes – is the distribution of aerosol droplet sizes.

      PIXE cascade impactor

      The instrument named the PIXE cascade impactor allows to classify different aerosol droplets in size on different collection plates. From this, it is possible to determine how the aerosol mass distributes in size and to extract a single representative size parameter useful to evaluate product performance and risk evaluation for toxicological purposes. To perform such evaluation, an instrument is used under Good Laboratory Practice to ensure scientific quality and data traceability. 

      Laser Aerosol Spectrometer – Droplet size distribution for e-cigarette platforms

      Measuring instantaneous droplet sizes is not possible with the PIXE cascade impactor because each analysis needs time. In contrast, the Laser Aerosol Spectrometer allows to overcome this limitation. We set up the instrument to specifically measure e-cigarette type products, allowing to determine whether the aerosol droplet size is within the required specifications. Product development continues until reaching target product performance. To this end, a complete and novel methodology was developed using the state-of-art tool Laser Aerosol Spectrometer.

      Read the related peer-reviewed article here: A Scattering Methodology for Droplet Sizing of E-Cigarette Aerosols