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Analysis of aromatic amines in THS aerosol
PMI
The aerosols are generated on a linear smoking machine and collected using a Cambridge filter pad (CFP) followed by an impinger filled with 15 mL of a 5% hydrochloric acid solution. The content of the CFP is combined and extracted with the content of the impinger after addition of internal standards. The resulting solution is then cleaned and trace-enriched using a solid-phase extraction procedure (SPE) and basified. The basic extract is further cleaned and trace-enriched using a second SPE. The obtained solution is derivatized with heptafluorobutyric anhydride (HFBA).
The derivatized solutions are analyzed by Gas Chromatography with Negative Chemical Ionization Mass Spectrometry detection (GC-NCI-MS) using a column DB-5M, 30 m x 0.25 mm ID x 0.25 µm film thickness. Results are expressed as ng/item for the Tobacco Heating System (THS), referred to as Platform 1 (P1) in the method.
Application of secondary electrospray ionization coupled with high-resolution mass spectrometry in chemical characterization of thermally generated aerosols
Comprehensive Chemical Characterization of the Aerosol Generated by Heated Tobacco Product
Scientific substantiation of the absence of Environmental Tobacco Smoke (ETS) emission during use of the Electrically Heated Tobacco System (EHTS)
What is combustion and why the absence of combustion is important in Heated Tobacco Products?
Solid particle investigation in the mainstream of 3R4F reference combustible cigarettes and the mainstream aerosol of Tobacco Heating System THS2.2
Retention Index Prediction Combined with in silico Fragmentation Spectra Comparison for Increasing Confidence in Structural Elucidation Using Non-targeted Gas Chromatography Coupled with High Resolution Mass Spectrometry
PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris International’s efforts to develop and assess products that have the potential to reduce individual risk and population harm associated with tobacco use. This site is for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not for advertising or marketing. It is not intended for use by consumers.
Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. Our RRPs are smoke-free products that produce an aerosol that contains far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.