PMI
The aerosols are generated on a linear smoking machine and collected using a Cambridge filter pad (CFP) followed by an impinger filled with 15 mL of a 5% hydrochloric acid solution. The content of the CFP is combined and extracted with the content of the impinger after addition of internal standards. The resulting solution is then cleaned and trace-enriched using a solid-phase extraction procedure (SPE) and basified. The basic extract is further cleaned and trace-enriched using a second SPE. The obtained solution is derivatized with heptafluorobutyric anhydride (HFBA).
The derivatized solutions are analyzed by Gas Chromatography with Negative Chemical Ionization Mass Spectrometry detection (GC-NCI-MS) using a column DB-5M, 30 m x 0.25 mm ID x 0.25 µm film thickness. Results are expressed as ng/item for the Tobacco Heating System (THS), referred to as Platform 1 (P1) in the method.
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Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. Our RRPs are smoke-free products that produce an aerosol that contains far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.