The aerosol samples are generated with a linear smoking machine and collected with two micro impingers filled with 25 mM DNPH extraction solution to allow DNPH-derivatization of carbonyls. The solution is then stabilized with pyridine and sent to the analytical laboratory for analysis. The extracts are analyzed by Ultra Performance Liquid Chromatography (UPLC) coupled to a tandem mass spectrometry with an Electrospray Ionization (ESI) interface in negative mode. The UPLC system is equipped with a column Waters Acquity BEH C18 1.7 μm, 2.1 x 50 mm. Results are expressed as μg/item for the Tobacco Heating System (THS), referred to as Platform 1 (P1) in the method.