Methods and Protocols

      Analysis of eight carbonyls in THS aerosol

      PMI

      Published on
      Mar 14, 2017
      Topic
      Summary

      The aerosol samples are generated with a linear smoking machine and collected with two micro impingers filled with 25 mM DNPH extraction solution to allow DNPH-derivatization of carbonyls. The solution is then stabilized with pyridine and sent to the analytical laboratory for analysis. The extracts are analyzed by Ultra Performance Liquid Chromatography (UPLC) coupled to a tandem mass spectrometry with an Electrospray Ionization (ESI) interface in negative mode. The UPLC system is equipped with a column Waters Acquity BEH C18 1.7 μm, 2.1 x 50 mm. Results are expressed as μg/item for the Tobacco Heating System (THS), referred to as Platform 1 (P1) in the method.

      PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris International’s efforts in support of its smoke-free product portfolio. This site is a global site for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not advertising or marketing, nor is it directed at any specific market. It is not intended for use by consumers. New tobacco products sold in the United States are subject to FDA regulation; therefore the content of this site is not intended to make, and nor should it be construed as making, any product related claims in the United States without proper FDA authorization. ​
      ​
      Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. All of our RRPs are smoke-free products that deliver nicotine with far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.