The aerosol samples are generated with a linear smoking machine and collected on a Cambridge filter pad. Target compounds are then extracted with a 100 mM ammonium acetate solution containing the internal standards. The extracts are analyzed by High Performance Liquid Chromatography (HPLC) using a tandem mass spectrometry with an Heat Electrospray Ionization (HESI) interface in positive mode. The HPLC system is equipped with a column Supelco Discovery HC-C18 column, 50 x 2.1 mm ID x 3.0 μm. Results are expressed as ng/item for the Tobacco Heating System (THS), referred to as Platform 1 (P1) in the method.
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Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. Our RRPs are smoke-free products that produce an aerosol that contains far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.