-
Home
- About PMI
-
Smoke-free approach
- What is harm reduction?
- Absence of combustion
- Nicotine
- The role of smoke-free products
- Tar
- Tobacco Regulation
Smoke-free approachOffering smoke-free alternatives to adult smokers is a sensible, complementary addition to existing tobacco control strategies.Read More -
Research
- Our Scientific Approach
- Our Findings
- PMI Publications Library
- Literature Reviews
- Independent Studies
- Investigator Initiated Studies (IIS)
- Latest PMI Science Booklet
- Facts and figures on our smoke-free future
ResearchPMI is committed to sharing results as the development and scientific assessment of smoke-free products advance.Read More -
Our Products
- Tobacco Heating System
- Oven Heating System
- MESH Vaping System
- Disposable Vaping System
- Oral Nicotine Pouches
- Nicotine salts product
Our ProductsPMI believes that offering a range of smoke-free alternatives is essential to ensure individual smokers are able to find a smoke-free product that they can fully switch to.Read More -
News & Events
- Scientific Update Magazine
- Open Science Events
- News
- Conferences Calendar
- Media Library
News & EventsRead our most recent articles and catch up on our latest events and conference presentations.Read More - Contact Us
Association of urinary 11-dehydro-thromboxane B2 levels in smoking, smoking cessation and Tobacco Heating System use
Gonzalez Zuloeta, A.; Pouly, S.; de La Bourdonnaye, G.; Baker, G.; Luedicke, F.
Smoking has been associated with cardiovascular disease and there is evidence that this might be mediated by the increased production of thromboxane. Whether metabolites of thromboxane, such as 11-dehydro-thromboxane B2 (TXB2), could be used as a biomarker of risk in the assessment of candidate modified risk tobacco products (MRTPS) is not clear. The aim of this literature review and meta-analysis (MA) was to determine the association of smoking status and TXB2 levels. Additionally we evaluated the effect of smoking cessation and the use of a tobacco heated system (THS) currently in development, to urinary levels of 11-dehydro-thromboxane B2.
Nicotine Pharmacokinetics of THS Single Use of a Regular or a Menthol Stick Compared to CIG
Reduction in exposure to selected harmful and potentially harmful constituents approaching those observed upon smoking abstinence in smokers switching to the menthol Tobacco Heating System 2.2 for three months (Part 1)
Reduction in exposure to selected harmful and potentially harmful constituents approaching those observed upon smoking abstinence in smokers switching to the menthol Tobacco Heating System 2.2 for three months (Part 1)
Meta-analysis of the effects of smoking and smoking cessation on triglyceride levels
Smoking and apolipoprotein levels: A meta-analysis of published data
Effect of switching from cigarette smoking to the use of the tobacco heating system on periodontitis treatment outcome: Periodontal parameter results from a multicenter Japanese study
PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris International’s efforts to develop and assess products that have the potential to reduce individual risk and population harm associated with tobacco use. This site is for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not for advertising or marketing. It is not intended for use by consumers.
Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. Our RRPs are smoke-free products that produce an aerosol that contains far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.