Presentations

      Comparative Assessment of Lung Inflammation, Pulmonary Function and Emphysema Caused by the Aerosol from Potential Reduced Risk Products and Cigarette Smoke in Mouse Models of COPD

      Vanscheeuwijck, P.; Phillips, B.; Wong, E. T.; Hoeng, J.; Peitsch, M. C.

      Conference date
      Jul 11, 2016
      Conference name
      3rd International Conference on Chronic Obstructive Pulmonary Disease 
      Link to more information
      Link to more information
      Topic
      Summary

      Smoking cigarettes is a major risk factor in the development and progression of chronic obstructive pulmonary disease (COPD). Potential Reduced Risk Products (RRPs*), are being developed to reduce smoking-related health risks compared to smoking cigarettes.  Here we report on mouse studies that have been conducted comparing different aspects of COPD after exposure of different strains to mainstream smoke (MS) from the reference cigarette 3R4F and aerosols from RRPs. Exposures were carried out for up to 8 months for several hours per day and at concentrations up to 30 µg nicotine/l test atmosphere. MS from 3R4F caused significant lung inflammation as evidenced by recruitment of inflammatory cells and pro-inflammatory cytokines in broncho-alveolar lavage fluid, changed pulmonary function parameters (e.g. resistance, PV-loops) indicative for emphysema and quantifiable emphysematous changes in the lung parenchyma. Exposure to high concentrations of aerosols from RRPs resulted in changes of a much lower magnitude and in a number of cases changes were not different from Sham (air)-exposed animals. Switching mice from exposure to MS for 2 months to aerosol from RRPs, resulted in the reversal of the emphysematous changes similar to those noticed when animals are switched from exposure of MS to fresh air. In summary, we have demonstrated in different mouse models that the RRPs, in contrast to 3R4F, cause a low level of lung inflammation and minimal pulmonary emphysema. 

      PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris International’s efforts in support of its smoke-free product portfolio. This site is a global site for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not advertising or marketing, nor is it directed at any specific market. It is not intended for use by consumers. New tobacco products sold in the United States are subject to FDA regulation; therefore the content of this site is not intended to make, and nor should it be construed as making, any product related claims in the United States without proper FDA authorization. ​
      ​
      Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. All of our RRPs are smoke-free products that deliver nicotine with far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.