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About PMI
Determination of hydrogen cyanide in cigarette mainstream smoke by LC/MS/MS
An LC/MS/MS method is presented for the determination of hydrogen cyanide in cigarette mainstream smoke. Cyanide is derivatized with 2,3'-naphthalenedicarboxaldehyde and taurine to form a benzo[f]isoindole derivative, which is then analyzed by LC/MS/MS. Isotopic KCN (K13C15N) was used as an internal standard. The regression equation was linear within the range 2.4-331 ng/mL for cyanide with a correlation coefficient > 0.999. The LOD was calculated as 4.1 ng/cigarette. The influence of the sodium hydroxide trapping solution concentration on the results is discussed. A 1 M solution showed the best results in terms of sample stability and trapping efficiency. The method proved to be robust, reliable, and more selective than current methods, making it a logical choice for determination of total cyanide in cigarette smoke.
Indoor Air Chemistry - An exploratory study on e-cigarette shows no negative impact on indoor air quality
Indoor air chemistry - An exploratory study on e-cigarette shows no negative impact on indoor air quality
Computer-Assisted Structure Identification (CASI) for high-throughput identification of small molecules using GC×GC-HRAM-TOFMS high-resolution accurate mass spectrometry
Computer-Assisted Structure Identification (CASI) for high-throughput identification of small molecules using GC×GC-HRAM-TOFMS high-resolution accurate mass spectrometry
Air quality assessment during indoor use of the Tobacco Heating System 2.2
Air quality assessment during indoor use of the Tobacco Heating System THS 2.2
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