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Smoke-free approachOffering smoke-free alternatives to adult smokers is a sensible, complementary addition to existing tobacco control strategies.Read More -
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Effects of aerosol from the Tobacco Heating System (THS) on human organotypic cultures of the aerodigestive tract
Cigarette smoking is responsible for a multitude of health risks and is one of the major modifiable risk factors for many smoking-related diseases. Tobacco Heating System (THS) is an electronic device, which heats tobacco instead of burning it. The THS aerosol has a different chemical composition to cigarette smoke, with its levels of harmful and potentially harmful constituents reduced on average by 90-95%. Advances in tissue engineering have enabled the development of sophisticated, three-dimensional organotypic culture systems that closely resemble human physiology. In several recent studies, buccal, gingival, nasal, bronchial, and small airway human epithelial organotypic cultures were exposed to aerosol from the THS and cigarette smoke. Standard toxicological assays were combined with network-based systems toxicology analyses to identify otherwise undetectable cellular-level effects. The results showed that the THS aerosol has a minimal biological impact on cells in comparison to cigarette smoke.
Effects of aerosol from the Tobacco Heating System (THS) on human organotypic cultures of the aerodigestive tract
Systems Toxicology In ApoE-/- Mice Demonstrates Smoking Cessation Benefits For Both Cardiovascular And Lung Disease-Related Endpoints
Sytems toxicological-based assessment of sex-related differences in response to cigarette smoke within an OECD rat inhalation study
Quantitative Proteomics to Investigate the Effects of a Prototype Modified Risk Tobacco Product (pMRTP) and Smoking Cessation on Mouse Lung Proteome
Systems Toxicology Approaches Enable Mechanistic Comparison Of Cigarette Smoke-Induced And Spontaneous Lung Tumors In The A/J Mouse Model
Physiologically based Pharmacokinetic Modeling of Nicotine from Inhaled Aqueous Aerosol Predicts Marked Gastrointestinal Absorption in Rats
PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris International’s efforts to develop and assess products that have the potential to reduce individual risk and population harm associated with tobacco use. This site is for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not for advertising or marketing. It is not intended for use by consumers.
Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. Our RRPs are smoke-free products that produce an aerosol that contains far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.