Posters

      Formaldehyde-Glycerol Hemiacetal - Absence of “Hidden” Formaldehyde in THS 2.2. Aerosols

      Knorr, A.; Gautier, L.; Debrick , A.; Tekeste, E.; Buchholz, C.; Almstetter, M.; Arndt, D.; Bentley, M.

      Conference date
      Mar 14, 2012
      Conference name
      3D Cell Culture DECHEMA Conference
      Link to more information
      Topic
      Summary

      Reduced Risk Products (“RRPs”*) is the term used by PMI to refer to products with the potential to reduce individual risk and population harm in comparison to smoking cigarettes. We are developing a portfolio of products with the potential to reduce risk for adult smokers with a significant reduction in the levels of harmful and potentially harmful constituents (HPHCs) demonstrated in extensive and rigorous scientific studies. Along with many other HPHCs, formaldehyde levels measured in the aerosol generated by our THS**2.2 heat not burn platform was found to be reduced by 90% compared to the levels measured in the smoke of reference cigarette 3R4F2 on a per stick basis.*** In a recent correspondence in The New England Journal of Medicine from Jensen et al. the authors discussed the formation of hemiacetals from formaldehyde and humectants like propylene glycol or glycerol, associated with a potential risk of underestimating the uptake of formaldehyde by using e-cigarettes while operating under extreme energy delivery to the liquid. The formaldehyde hemiacetal (known as formaldehyde releasing agent) might represent a “hidden” formaldehyde, not covered by classical analytical approaches, releasing the formaldehyde portion after inhaling.  

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      Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. All of our RRPs are smoke-free products that deliver nicotine with far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.