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Gas chromatographic—mass spectrometric analysis of acrylamide and acetamide in cigarette mainstream smoke after on-column injection
A method is described for the simultaneous determination of two short-chained amides, acrylamide and acetamide (classified by the International Agency for Research on Cancer as probable and possible human carcinogens, respectively), in total particulate matter using gas chromatography-on-column injection and mass spectrometric detection. Sample preparation is kept to a minimum, and the proposed analytical procedure proves to be fast, sensitive, and precise. Validation studies show good linearity with a regression coefficient of r2=.000 for both compounds. Quantitation limits are 32 ng/mL for acrylamide and 70 ng/mL for acetamide. In the particulate phase of mainstream smoke from the University of Kentucky Reference Cigarette 2R4F, 2.3 µg/cig acrylamide and 4.7 µg/cig acetamide are found; no acetamide and only .0074 µg/cig acrylamide is found in the gas phase. Possible mechanisms of formation in cigarette smoke are discussed.
Application of secondary electrospray ionization coupled with high-resolution mass spectrometry in chemical characterization of thermally generated aerosols
Comprehensive Chemical Characterization of the Aerosol Generated by Heated Tobacco Product
Scientific substantiation of the absence of Environmental Tobacco Smoke (ETS) emission during use of the Electrically Heated Tobacco System (EHTS)
What is combustion and why the absence of combustion is important in Heated Tobacco Products?
Solid particle investigation in the mainstream of 3R4F reference combustible cigarettes and the mainstream aerosol of Tobacco Heating System THS2.2
Retention Index Prediction Combined with in silico Fragmentation Spectra Comparison for Increasing Confidence in Structural Elucidation Using Non-targeted Gas Chromatography Coupled with High Resolution Mass Spectrometry
PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris International’s efforts to develop and assess products that have the potential to reduce individual risk and population harm associated with tobacco use. This site is for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not for advertising or marketing. It is not intended for use by consumers.
Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. Our RRPs are smoke-free products that produce an aerosol that contains far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.