Peer-Reviewed Publications

      Lung inflammation in rats following subchronic exposure to cigarette mainstream smoke

      Friedrichs, B.; van Miert, E.; Vanscheeuwijck, P.
      Published
      Mar 31, 2006
      DOI
      10.1080/01902140600817457
      PMID
      16908445
      Link to publication
      Topic
      Summary

      Female Sprague-Dawley rats were exposed to mainstream smoke from standard reference cigarettes and a nontobacco cellulose cigarette for 35 days. Whole smoke and smoke fractions were investigated. Lung inflammation was evaluated by differentiation of bronchoalveolar lavage cells and lymphocytes in thoracic lymph nodes. Histopathological changes in the nose and larynx were assessed. Results showed that the particulate phase of cigarette mainstream smoke is mostly responsible for inflammation in the lung (neutrophil increase up to 240-fold) and hyperplastic and metaplastic epithelial changes in the larynx, whereas irritative volatile constituents in the gas phase are mostly responsible for changes in the nose.

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