Posters

      Pharmacokinetics of nicotine following single use of a candidate modified risk tobacco product: The Tobacco Heating System 2.1

      Haziza, C.; Baker, G.; Lama, N.; Ancerewicz, J. Ancerewicz.; Picavet, P.; Stewart, A. J.; Lüdicke, F.

      Conference date
      Feb 5, 2014
      Conference name
      Society for Research on Nicotine and Tobacco (SRNT) 2014
      Link to more information
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      Topic
      Summary

      To those smokers who are not able or not willing to quit, Philip Morris International (PMI) is investigating alternative approaches by developing products with the potential to reduce the risks of tobacco-related diseases. These products are now referred to by the US Food and Drug Administration as modified risk tobacco products (MRTPs). The challenge in developing and commercializing MRTPs is two-fold, (i.e., developing tobacco products that are shown to reduce risk and that are acceptable to smokers as substitutes for conventional cigarettes (CC). The Tobacco Heating System (THS) 2.1, the MRTP tested in this study is based on the concept  that tobacco is heated at significantly lower temperatures than required for CC. The international  Organization on Standardization  (ISO) yield per THS Tobacco Sticks were: 7 mg for tar, 0.3 mg for nicotine, and  1 mg for carbon monoxide. There are a variety of nicotine-containing products on the market ranging from cigarettes, oral snuff, chewing tobacco to nicotine replacement therapy products (NRT) (gum, inhaler, nasal spray, etc.). There is a large variability of nicotine absorption across this range of products (Molyneux, 2004). For conventional cigarettes, the nicotine is distilled from burning tobacco and carried on liquid droplets which are inhaled and absorbed rapidly across pulmonary membranes. Blood concentrations of nicotine rise very quickly during a smoking session and peak at the completion of smoking (Henningfield, 1995).  It is important to compare nicotine pharmacokinetics for THS 2.1 against CC.

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      Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. All of our RRPs are smoke-free products that deliver nicotine with far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.