Posters

      Systems toxicology analysis of cardiovascular and respiratory endpoints from Apoe-/- mice showed similar effects after switching to a candidate modified risk tobacco product, THS 2.2, or to smoking cessation

      Phillips, B.; Boue, S.; Vuillaume, G.; Martin, F.; Leroy, P.; Veljkovic, E.; Peitsch, M.; Hoeng, J.

      Conference date
      Mar 23, 2015
      Conference name

      Society of Toxicology (SOT) 2015
      Link to more information
      Topic
      Summary

      Cigarette smoking (CS) is the main risk factor for the development and progression of a series of diseases, including cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD). Suitable animal models play an important role in understanding of smoke-induced pathogenesis. This study examined the development of hallmarks of both COPD and CVD in Apoe-/- mice exposed to either CS or to an aerosol from a candidate modified risk tobacco product, the tobacco heating system (THS2.2) over an 8-month period. In addition to chronic exposure regimes, a comparison of exposure cessation or switching to THS2.2 after 2 months of exposure to CS was performed using a battery of assays (physiological, morphological and molecular). Biological interpretation of various endpoints enables to understand the biological effects of cessation/switching as compared to continuous smoking.  

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