Peer-Reviewed Publications

      Toxicological assessment of cigarette ingredients

      Dempsey, R.; Coggins, C. R. E.; Roemer, E.
      Published
      Jul 12, 2011
      DOI
      10.1016/j.yrtph.2011.07.002
      PMID
      21771627
      Link to publication
      Topic
      Summary

      Ingredients have been used in industrial manufacture of tobacco products since the early part of the 20th century. However, unlike other consumer goods, until now no regulatory authority has determined how tobacco ingredients should be assessed. Although there is currently no consensus on how added cigarette ingredients should be evaluated, this paper reviews some of the institutional guidance alongside published literature with a view to determining if there is a generally accepted approach in the absence of any strict regulation. Our aim was to review the recommendations, to compare them to the working practices as demonstrated from published studies, and to draw conclusions on currently used methodologies for testing ingredients added to cigarettes. The extent of testing is discussed in the light of practical and theoretical constraints and an example of an industry testing program is presented.

      Related Publications

      Preliminary toxicological assessment of heated tobacco products: A review of the literature and proposed strategy

      Aerosol Chemistry Pre-clinical Toxicology

      Performance of the flow cytometry-based in vitro micronucleus assay in a validation study

      Aerosol Chemistry Pre-clinical Toxicology

      Evaluation of an Electrically Heated Cigarette

      Aerosol Chemistry Pre-clinical Toxicology

      A mechanistic study of cigarette smoke-induced COPD and cessation effects in C57BL/6 mice

      Aerosol Chemistry Pre-clinical Toxicology

      Fourier Transformed Infrared (FTIR) Method For Continuous Real-Time Aerosol Characterization For In Vivo Studies

      Aerosol Chemistry Pre-clinical Toxicology

      Chemical Composition, In Vitro Toxicity, and Theoretical Risk Estimates of Smoke from Different U.S. Blended Cigarettes

      Aerosol Chemistry Pre-clinical Toxicology

      PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris International’s efforts to develop and assess products that have the potential to reduce individual risk and population harm associated with tobacco use. This site is for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not for advertising or marketing. It is not intended for use by consumers.

      Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. Our RRPs are smoke-free products that produce an aerosol that contains far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.