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About PMI
Tracing the composition of single e-cigarette aerosol droplets in situ by laser-trapping and Raman scattering
The partitioning of components between droplets and the gas phase in e-cigarette aerosols has a significant impact on deposition within the respiratory tract. However, exclusive detection of droplet composition has, so far, been elusive. Consequently, the dynamics of partitioning between droplets and the gas phase remains unknown. Here, we combine optical trapping of single droplets with in situ Raman scattering for destruction-free monitoring of e-cigarette droplet composition with a time resolution of seconds. We find that the initial droplet composition is very close to the composition of the e-liquid. Upon dilution with air, the droplet composition changes exponentially on a time scale of seconds, mainly because of evaporation of propylene glycol. The nicotine content in the droplet is controlled by the pH. Nicotine evaporates from the droplets under basic conditions, but remains in the liquid under acidic conditions. These results are crucial for advancing e-liquid research and manufacturing.
Combustion differentiating criterion for novel tobacco and nicotine products
Scientific Substantiation of the Absence of Combustion in a Novel Heated Tobacco Product
Scientific substantiation of the absence of combustion in the Electrically Heated Tobacco Product (EHTP) and that the aerosol emitted is not smoke
Scientific substantiation of the absence of combustion and no smoke formation in the Electrically Heated Tobacco Product (EHTP) as well as the absence of Environmental Tobacco Smoke (ETS) emission during use of the Electrically Heated Tobacco System (EHTS)
Scientific Substantiation of the Absence of Combustion in a Novel Heated Tobacco Product
The dos and don’ts of non-targeted screening by LC–HRAM-MS for chemical characterization of smoke-free products
PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris International’s efforts to develop and assess products that have the potential to reduce individual risk and population harm associated with tobacco use. This site is for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not for advertising or marketing. It is not intended for use by consumers.
Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. Our RRPs are smoke-free products that produce an aerosol that contains far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.