Cigarette smoke (CS) causes serious diseases and has detrimental effects on human health, including oral health. Smoking can lead to gingivitis, periodontitis, tooth loss, and mouth cancer. CS is also a risk factor for tooth discoloration. Pigmented compounds present in the particulate phase generated by combustion of tobacco may cause discoloration of dental hard tissues and restorative materials. Switching from cigarette smoking to using reduced-risk products (RRP) has the potential to reduce the harm and dental esthetic concerns associated with smoking. However, rigorous scientific studies are necessary to demonstrate the potentially reduced detrimental effects of exposure to aerosols from RRPs relative to those of exposure to CS. In this poster, we summarize the results of numerous in vitro studies that investigated the impact of exposure to aerosols from different RRPs (2 heated tobacco products [HTP] and 1 electronic vapor [e-vapor] product) on oral cell cultures and dental coloration. In addition, we present the results of a study aimed at characterizing the chemical compounds associated with tooth discoloration.