This 21st issue of the Scientific Update, published in June 2025, explores the work of our perception and behavior team. The issue features an interview with Steve Roulet, Global Head of Regulatory Insights, on the role of perception and behavior studies in advancing tobacco harm reduction. It also highlights the development of our proprietary tools for measuring and analyzing behaviors and outcomes related to tobacco and nicotine product use. Additionally, we provide an overview of two studies offering valuable insights into consumer perceptions and usage patterns of smoke-free products.