Analysis of the extent of emphysema in live mice by high resolution X-ray microtomography

      Postnov, A. A.; Meurrens, K.; Weiler, H.; Van Dyck, D.; Xu, H.; Terpstra, P.; De Clerck, N. M.
      Conference date
      Sep 9, 2005
      Conference name
      Society for Molecular Imaging Annual Meeting

      High resolution X-ray microtomography (micro-CT) was used for the detection of emphysema in live mice. Emphysema was induced in C57BL/6 J mice by intratracheal instillation of different amounts of porcine pancreatic elastase. This emphysema could be clearly detected by micro-CT seven weeks post-treatment: analysis of the whole data set of virtual cross-sections showed the presence of a dose-dependent level of emphysema.