Peer-Reviewed Publications

      In vivo assessment of emphysema in mice by high resolution X-ray microtomography

      Postnov, A. A.; Meurrens, K.; Weiler, H.; Van Dyck, D.; Xu, H.; Terpstra, P.; De Clerck, N. M.
      Published
      Nov 2, 2005
      DOI
      10.1111/j.1365-2818.2005.01510.x
      PMID
      16269065
      Link to publication
      Topic
      Summary

      High resolution X-ray microtomography (micro-CT) was used for the detection of emphysema in live mice. Emphysema was induced in C57BL/6 J mice by intratracheal instillation of different amounts of porcine pancreatic elastase. This emphysema could be clearly detected by micro-CT seven weeks post-treatment: Analysis of the whole data set of virtual cross-sections showed the presence of a dose-dependent level of emphysema.

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